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  1. 344601
    “…These results provide insights into the mechanisms by which APOE increases the risk of AD, emphasizing the importance of APOE genotype for future clinical trials in DS.…”
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    Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome
  2. 344602
    “…BACKGROUND: The most frequently reported treatment‐related adverse event in clinical trials with the cyclin‐dependent kinase 4/6 (CDK4/6) inhibitor palbociclib is neutropenia. …”
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    Evaluation of the Association of Polymorphisms With Palbociclib‐Induced Neutropenia: Pharmacogenetic Analysis of PALOMA‐2/‐3
  3. 344603
    “…Method: Baseline data from 217 men between age of 35–65 who were participants in 2 clinical trials conducted at the Michael DeBakey VA Medical Center and the New Mexico VA Health Care System were analyzed. …”
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    Hemoglobin A1c of 7% is the Threshold For Bone Impairment in Men With Type 2 Diabetes Mellitus
  4. 344604
    “…SIMPLE SUMMARY: In first clinical trials, vaccinations against tumor-associated antigens (TAA), such as Alpha-Fetoprotein (AFP) using antigen presenting cells, such as dendritic cells (DC), failed to achieve effective immune responses towards hepatocellular carcinoma (HCC). …”
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    Alpha-Fetoprotein- and CD40Ligand-Expressing Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma
  5. 344605
    “…We included epidemiological studies, observational studies, randomised trials, interventional studies, and case series published from 1999 to 2018 that showed the number of deaths and autopsy studies indicating the specific poisons or poison classes. …”
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    Importance of pesticides for lethal poisoning in India during 1999 to 2018: a systematic review
  6. 344606
    “…METHODS: Seven English and Chinese electronic databases (PubMed, Cochrane Library, Embase, CNKI, VIP, CBM, and Wanfang) were searched from inception to January 2020, to search for randomized controlled trials (RCTs) on TXLC combined with atorvastatin in the treatment of CHD. …”
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    Tongxinluo Capsule Combined with Atorvastatin for Coronary Heart Disease: A Systematic Review and Meta-Analysis
  7. 344607
    “…Further prospective randomized controlled trials are required to verify the beneficial effects of dual trigger. …”
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    Dual Trigger for Final Follicular Maturation Improves Cumulative Live-Birth Rate in Ovarian Stimulation for Freeze-All In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles
  8. 344608
    “…Future multicenter, randomized, double-blind, placebo-controlled trials investigating safety of hip CSI are needed.…”
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    Hip Corticosteroid/Anesthetic Injections—Are the reported rates of osteoarthritis progression and femoral head collapse real?
  9. 344609
    “…Mortality was numerically less in patients in receiving ruxolitinib who continued therapy, however this should be interpreted with caution given our small cohort. Further clinical trials to address the use of ruxolitinib are necessary and are ongoing. …”
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    Outcomes of COVID-19 Infection in Patients Receiving Ruxolitinib and Hypomethylating Agent Therapy
  10. 344610
    “…Kambhampati:AbbVie: Other: Investigator in AbbVie-sponsored clinical trials.. McSweeney:Kite, a Gilead Company: Consultancy, Honoraria, Research Funding, Speakers Bureau; Fred Hutchinson: Patents & Royalties; Colorado Blood Cancer Institute: Current Employment. …”
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    Reduction in Transplantation Activity without Impairment in Outcomes in the Covid-19 Era- Data from the Sarah Cannon Blood Cancer Network (SCBCN)
  11. 344611
    “…We continue to seek to improve management of these patients as new evidence of successful treatment emerges, and also encourage patients to participate in clinical trials. [Figure: see text] DISCLOSURES: No relevant conflicts of interest to declare.…”
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    Presentation, Management and Outcomes of COVID-19 Patients with Sickle Cell Disease
  12. 344612
    “…Results support the potential utility of blood biomarkers in measuring the benefits associated with health behaviors and may contribute to specifying target populations or informing interventions for trials that focus on improving physical activity behavior. …”
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    Longitudinal Association of Total Tau Concentrations and Physical Activity With Cognitive Decline in a Population Sample
  13. 344613
    “…METHOD: The PubMed, Embase and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for literature published from the initial to October 2020. …”
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    What is the impact of granulocyte colony-stimulating factor (G-CSF) in subcutaneous injection or intrauterine infusion and during both the fresh and frozen embryo transfer cycles on recurrent implantation failure: a systematic review and meta-analysis?
  14. 344614
    “…DESIGN: Mixed, cross-sectional study following an associative design. 61 males from multidirectional sports performed six 90° pre-planned cutting trials, whereby lower-limb and trunk kinetics and kinematics were evaluated using three-dimensional (3D) motion and ground reaction force analysis over the penultimate (PFC) and final foot contact (FFC). …”
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    Biomechanical Determinants of Performance and Injury Risk During Cutting: A Performance-Injury Conflict?
  15. 344615
    “…BACKGROUND: Randomized controlled trials showed that sodium/glucose cotransporter-2 inhibitors (SGLT2i) protect the heart and kidney in an array of populations with type 2 diabetes (T2D) and increased cardiorenal risk. …”
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    Cardiorenal outcomes with sodium/glucose cotransporter-2 inhibitors in patients with type 2 diabetes and low kidney risk: real world evidence
  16. 344616
    “…Few SRs arrived at a definitive conclusion, and more randomized controlled trials (RCTs) were published. We conducted this study to summarize the latest evidence of TCM in COVID-19. …”
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    Efficacy and Safety of Traditional Chinese Medicine in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis
  17. 344617
    “…Our aim was to draw definitive conclusions by conducting both a fixed and random model meta-analysis of quality randomized controlled trials (RCTs) and by comparison with related meta-analyses. …”
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    Direct anterior approach (DAA) vs. conventional approaches in total hip arthroplasty: A RCT meta-analysis with an overview of related meta-analyses
  18. 344618
    por Tulipan, Julia, Kofler, Barbara
    Publicado 2021
    “…The first KD clinical trials in patients with glioblastoma revealed good acceptance and a possible anti-tumor effect. …”
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    Implementation of a Low-Carbohydrate Diet Improves the Quality of Life of Cancer Patients – An Online Survey
  19. 344619
    “…This study is registered with ClinicalTrials.gov, number NCT02667756. FINDINGS: We enrolled 150 patients at a median of 17 days (range 1–59, IQR 9–26) after knee injury. 123 (82%) were male, with a median age of 25 years (range 16–50, IQR 21–30). 98 (65%) of 150 participants completed a KOOS(4) at 2 (or 3) years after enrolment (50 participants were lost to follow-up and two were withdrawn due to adverse events unrelated to study participation); 77 (51%) participants had all necessary variables available and were included in the core variable adjusted analysis. …”
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    Clinical and molecular associations with outcomes at 2 years after acute knee injury: a longitudinal study in the Knee Injury Cohort at the Kennedy (KICK)
  20. 344620
    “…RLT has yielded promising anti-tumoral activity and excellent tolerability in patients with mCRPC as shown by multiple retrospective series and a growing number of prospective trials. The presented study aims to investigate the role of RLT in mCRPC patients with metastases diffusely involving the bone marrow. …”
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    Salvage Radioligand Therapy with Repeated Cycles of (177)Lu-PSMA-617 in Metastatic Castration-Resistant Prostate Cancer with Diffuse Bone Marrow Involvement
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