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344801“…SUMMARY: Several large trials and meta-analyses have investigated the effects of lipid-lowering statin therapy and have consistently demonstrated that statin therapy significantly reduces LDL-C levels and incidence of cardiovascular events. …”
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344802“…Hearing-related AEs have been reported in ∼10% of pts receiving teprotumumab in trials. Although hearing loss has been observed with GD,(1) the prevalence is unclear with no independent/cumulative risk data in pts with TED and pts receiving teprotumumab. …”
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344803“…The potential perinatal harm needs more research. ClinicalTrials.gov NCT04862390 Presentation: Saturday, June 17, 2023…”
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344804por Taylor, Melissa, Tapkigen, Janet, Ali, Israa, Liu, Qin, Long, Qian, Nabwera, Helen“…SELECTION CRITERIA: We included randomised controlled trials (RCTs), cohort studies, and controlled before‐after studies that compared GMP with standard care or nutrition education alone in non‐hospitalised children aged under five years. …”
Publicado 2023
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344805por Tanimura, Keiko, Takeda, Takayuki, Kataoka, Nobutaka, Yoshimura, Akihiro, Nakanishi, Kentaro, Yamanaka, Yuta, Yoshioka, Hiroshige, Honda, Ryoichi, Uryu, Kiyoaki, Fukui, Mototaka, Chihara, Yusuke, Takei, Shota, Kawachi, Hayato, Yamada, Tadaaki, Tamiya, Nobuyo, Okura, Naoko, Yamada, Takahiro, Murai, Junji, Shiotsu, Shinsuke, Kurata, Takayasu, Takayama, Koichi“…ABSTRACT: Background: The long overall survival (OS) observed among patients with non-small cell lung cancer (NSCLC) with high programmed death-ligand 1 (PD-L1) expression in chemoimmunotherapy (CIT) groups in previous phase III trials suggests the limited efficacy of CIT among the subgroup with ≤49% PD-L1 expression on tumor cells. …”
Publicado 2023
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344806por Temme, Leonard A., Wittels, Harrison L., Wishon, Michael J., St. Onge, Paul, McDonald, Samantha M., Hecocks, Dustin, Wittels, S. Howard“…The aviators’ ANS responses were measured throughout the nearly two hours of trials. Our study observed heightened sympathetic nervous system activity (e.g., “fight or flight”) and found suggestions of increased anxiety. …”
Publicado 2023
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344807por Charles, Reema, Milani, Barbara, Dagne, Daniel Argaw, Ali, Bisma, Stone, Heather, Schito, Marco, Tirupathi, Raghavendra, Oliver, Nalini“…This is an area of high unmet need and merit a systematic approach to capture large volumes of RWD for potential efficacy signals and hypothesis generation to inform clinical trials. DISCLOSURES: All Authors: No reported disclosures…”
Publicado 2023
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344808por Sension, Michael, Hsu, Ricky K, Fusco, Jennifer S, Brunet, Laurence, Cochran, Quateka, Sridhar, Gayathri, Vannappagari, Vani, van Wyk, Jean A, Wohlfeiler, Michael B, Fusco, Gregory P“…Wohlfeiler, JD, MD, AAHIVS, ViiV Healthcare: Serves as a PI on clinical trials, but does not receive personal compensation for this work (it goes directly to AIDS Healthcare Foundation) Gregory P. …”
Publicado 2023
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344809por Estévez, Samuel, Buzón, Luis, Pousada, Guillermo, Tomé, Roberto Pedrero, Galera, Carlos, Sanz, Jose, Santos, Ignacio, Dueñas, Carlos, Cabello, Noemí, Martín, Cristina, Galindo, María José, Garcinuño, María Ángeles, Hernández, Cristina, Lebón, Gabriela, Fernández, Beatriz, Troya, Jesús“…BACKGROUND: Switching strategy with bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) has become a gold standard for people with HIV (PLWHIV) with high efficacy and safety rates in long-term data of pivotal clinical trials. However, data regarding immune status restoration in real-life cohorts of long-time treated patients are needed. …”
Publicado 2023
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344810por Valenti, William M, Phoenix, John, Patel, Rupa R, Tims-Cook, Zandraetta, Pilgrim, Nanlesta, Haley, Amber, Sutton, Kenneth, Gaudion, Alison, Merrill, Deanna, Urbaityte, Rimgaile, Li, Bo, Andrae, David, Bonner, Courtney, Herbst, Abigail, Chowdhury, Dhuly, Garges, Harmony, Czarnogorski, Maggie“…BACKGROUND: EBONI and PILLAR are Phase IV implementation science trials evaluating the integration of long-acting injectable Cabotegravir for PrEP (CAB LA) into standard of care at 37 clinics across the U.S. …”
Publicado 2023
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344811por Hsu, Ricky K, Sension, Michael, Fusco, Jennifer S, Brunet, Laurence, Cochran, Quateka, Sridhar, Gayathri, Vannappagari, Vani, van Wyk, Jean A, Wohlfeiler, Michael B, Fusco, Gregory P“…Wohlfeiler, JD, MD, AAHIVS, ViiV Healthcare: Serves as a PI on clinical trials, but does not receive personal compensation for this work (it goes directly to AIDS Healthcare Foundation) Gregory P. …”
Publicado 2023
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344812por Clegg, Lindsay E, Stepanov, Oleg, Schmidt, Henning, Reddy, Ventakesh Pilla, Tang, Weifeng, Gibbs, Michael, Sedani, Sangeeta, Tuillio, Antonella Nadia, Sadow, Sam, Martinez-Alier, Nuria, Cohen, Taylor, Faust, Saul N, Esser, Mark T, Någård, Mats“…A population pharmacokinetic (popPK) model for AZD7442 included interim data from phase 3 trials in pre-exposure prophylaxis (PreP; PROVENT), post-exposure prophylaxis (STORMCHASER), and treatment of mild-to-moderate COVID-19 (TACKLE) in adults. …”
Publicado 2023
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344813“…The research methodology involved analyzing randomized controlled trials (RCTs), as well as prospective or retrospective cohort studies, which compared the long-term prognosis of patients with ovarian cancer under general anesthesia combined with epidural anesthesia (GEA) versus general anesthesia alone (GA). …”
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344814por Müller-Riemenschneider, Falk, Schwarzbach, Christoph, Bockelbrink, Angelina, Ernst, Iris, Vauth, Christoph, Willich, Stefan N., von der Schulenburg, Johann-Matthias“…Overall study quality is limited and with the exception of two randomized controlleed trials (RCT) and two meta-analyses only historical cohort studies are identified. …”
Publicado 2009
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344815por Damm, Oliver, Nocon, Marc, Roll, Stephanie, Vauth, Christoph, Willich, Stefan, Greiner, Wolfgang“…METHODS: Based on a systematic literature review, randomized controlled trials (RCT) looking at the effectiveness of HPV vaccination for the prevention of cervical carcinoma and its precursors - cervical intraepithelial neoplasia - have been identified. …”
Publicado 2009
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344816por Schnell-Inderst, Petra, Kossmann, Beate, Fischereder, Michael, Klauss, Volker, Wasem, Jürgen“…The two randomized clinical trials analysing the effect of orally supplemented vitamin E on clinical endpoints in patients with mild-to-moderate renal insufficiency and for haemodialysis patients respectively reported different results. …”
Publicado 2006
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344817por Balzer, Katrin, Bremer, Martina, Schramm, Susanne, Lühmann, Dagmar, Raspe, Heiner“…While the effectiveness of interventions is solely assessed on the basis of randomised controlled trials (RCT), the assessment of the effectiveness of diagnostic procedures also considers prospective accuracy studies. …”
Publicado 2012
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344818“…In order to define the size of the prosthesis, multiple trials are tested. It is important not to exceed the height of the healthy adjacent disc to avoid facet joint overdistraction. …”
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344819por Flegg, Jennifer A, Guérin, Philippe J, Nosten, Francois, Ashley, Elizabeth A, Phyo, Aung Pyae, Dondorp, Arjen M, Fairhurst, Rick M, Socheat, Duong, Borrmann, Steffen, Björkman, Anders, Mårtensson, Andreas, Mayxay, Mayfong, Newton, Paul N, Bethell, Delia, Se, Youry, Noedl, Harald, Diakite, Mahamadou, Djimde, Abdoulaye A, Hien, Tran T, White, Nicholas J, Stepniewska, Kasia“…METHODS: A total of 2,746 parasite density-time profiles were selected from 13 clinical trials in Thailand, Cambodia, Mali, Vietnam, and Kenya. …”
Publicado 2013
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344820por Singh, Ajai R.“…Psychotherapy must be clearly defined, its parameters and methods firmly delineated, its proof of effectiveness convincingly demonstrated by evidence based and controlled trials; b. Psychotherapy research suffers from neglect by the mainstream at present, because of the ascendancy of biological psychiatry; c. …”
Publicado 2014
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