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344821por Mitton, Kenneth P., Guzman, Alvaro E., Deshpande, Mrinalini, Byrd, David, DeLooff, Camryn, Mkoyan, Kristina, Zlojutro, Paul, Wallace, Adrianne, Metcalf, Brandon, Laux, Kirsten, Sotzen, Jason, Tran, Trung“…This generated speculation for VPA’s potential to increase the expression of neuroprotective genes. Clinical trials for retinitis pigmentosa (RP) are currently active, testing VPA’s potential to reduce photoreceptor loss; however, we lack information regarding the effects of VPA on available mammalian models of retinal degeneration, nor do we know if retinal gene expression is perturbed by VPA in a predictable way. …”
Publicado 2014
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344822“…STUDY ELIGIBILITY CRITERIA: Initially, 209 articles were identified for review. Only controlled trials were included if they investigated STU in healthy individuals and tested at least one measure of maximal strength, strength endurance, muscle power, or static/dynamic balance. …”
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344823Publicado 2016“…We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. …”
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344824Publicado 2017“…We extracted relative risk (RR) and exposure estimates from 22 717 randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources, according to the GBD 2016 source counting methods. …”
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344825“…E.M.D.R therapy is an empirically valid treatment for P.T.S.D, based on numerous randomized controlled trials and several meta-analyses (e.g. Chen, Zhang, Hu, & Liang, 2015; Nijdam & Olff, 2016). …”
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344826“…As such, this meta-analytic review was conducted to examine the efficacy of cognitive intervention in individuals diagnosed with mild cognitive impairment (MCI) versus MCI controls based on performance of neuropsychological outcome measures in randomized controlled trials (RCT). RCT studies published from January 1995 to June 2017 were obtained through source databases of MEDLINE-R, PubMed, Healthstar, Global Health, PSYCH-INFO, and Health and Psychological Instruments using search parameters for MCI diagnostic category (mild cognitive impairment, MCI, pre-Alzheimer’s disease, early cognitive decline, early onset Alzheimer’s disease, and preclinical Alzheimer’s disease) and the intervention or training conducted (intervention, training, stimulation, rehabilitation, or treatment). …”
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344827por Foss-Feig, Jennifer, Velthorst, Eva, Guillory, Sylvia, Hamilton, Holly, Roach, Brian, Bachman, Peter, Belger, Aysenil, Carrion, Ricardo, Duncan, Erica, Johannesen, Jason, Light, Gregory, Niznikiewicz, Margaret, Addington, Jean, Cadenhead, Kristin, Cannon, Tyrone, Cornblatt, Barbara, McGlashan, Thomas, Perkins, Diana, Seidman, Larry, Tsuang, Ming, Walker, Elaine, Woods, Scott, Bearden, Carrie, Mathalon, Daniel“…P300 event-related potentials (ERP) were extracted from ongoing EEG collected at baseline in response to Target and Novel auditory and visual stimuli, each presented on 10% of trials within streams of 80% standard stimuli in the same modality. …”
Publicado 2018
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344828por Mody, Aaloke, Sikazwe, Izukanji, Czaicki, Nancy L., Wa Mwanza, Mwanza, Savory, Theodora, Sikombe, Kombatende, Beres, Laura K., Somwe, Paul, Roy, Monika, Pry, Jake M., Padian, Nancy, Bolton-Moore, Carolyn, Holmes, Charles B., Geng, Elvin H.“…BACKGROUND: Although randomized trials have established the clinical efficacy of treating all persons living with HIV (PLWHs), expanding treatment eligibility in the real world may have additional behavioral effects (e.g., changes in retention) or lead to unintended consequences (e.g., crowding out sicker patients owing to increased patient volume). …”
Publicado 2018
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344829por Llanos-Cuentas, Alejandro, Casapia, Martin, Chuquiyauri, Raúl, Hinojosa, Juan-Carlos, Kerr, Nicola, Rosario, Maria, Toovey, Stephen, Arch, Robert H, Phillips, Margaret A, Rozenberg, Felix D, Bath, Jade, Ng, Caroline L, Cowell, Annie N, Winzeler, Elizabeth A, Fidock, David A, Baker, Mark, Möhrle, Jörg J, Hooft van Huijsduijnen, Rob, Gobeau, Nathalie, Araeipour, Nada, Andenmatten, Nicole, Rückle, Thomas, Duparc, Stephan“…This study is registered at ClinicalTrials.gov (NCT02123290). FINDINGS: Between Jan 12, 2015, and Dec 2, 2015, 45 Peruvian patients (24 with P falciparum [cohort a] and 21 with P vivax [cohort b] infection) were sequentially enrolled. …”
Publicado 2018
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344830por Abubakar, Ibrahim, Drobniewski, Francis, Southern, Jo, Sitch, Alice J, Jackson, Charlotte, Lipman, Marc, Deeks, Jonathan J, Griffiths, Chris, Bothamley, Graham, Lynn, William, Burgess, Helen, Mann, Bobby, Imran, Ambreen, Sridhar, Saranya, Tsou, Chuen-Yan, Nikolayevskyy, Vladyslav, Rees-Roberts, Melanie, Whitworth, Hilary, Kon, Onn Min, Haldar, Pranab, Kunst, Heinke, Anderson, Sarah, Hayward, Andrew, Watson, John M, Milburn, Heather, Lalvani, Ajit“…The study was registered with ClinicalTrials.gov, NCT01162265, and is now complete. FINDINGS: Between May 4, 2010, and June 1, 2015, 10 045 people were recruited, of whom 9610 were eligible for inclusion. …”
Publicado 2018
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344831“…Whilst stand-alone registries had the capacity to uncover the natural history of disease, develop best practice, replace clinical trials, and improve patient outcomes, they were limited in their capacity to conduct basic research. …”
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344832por Freifeld, Alison G, Zimmer, Andrea, Arnold, Christopher, Baddley, John W, Chandrasekar, Pranatharthi, Boghdadly, Zeinab El, Maziarz, Eileen K, Montoya, Jose G, Pergam, Steven, Rolston, Kenneth V, Satyanarayana, Gowri, Shoham, Shmuel, Strasfeld, Lynne, Taplitz, Randy, Walsh, Thomas J, Young, Jo-Anne, Zhang, Yuning, Meza, Jane“…Young, GSK: Investigator, The University of Minnesota is reimbursed for contract costs associated with conducting clinical trials of vaccine. I receive no personal financial benefit. …”
Publicado 2018
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344833por Aldridge, Robert W, Nellums, Laura B, Bartlett, Sean, Barr, Anna Louise, Patel, Parth, Burns, Rachel, Hargreaves, Sally, Miranda, J Jaime, Tollman, Stephen, Friedland, Jon S, Abubakar, Ibrahim“…METHODS: In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Library, and Google Scholar databases for observational studies, systematic reviews, and randomised controlled trials published between Jan 1, 2001, and March 31, 2017, without language restrictions. …”
Publicado 2018
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344834por Ovadia, Caroline, Seed, Paul T, Sklavounos, Alexandros, Geenes, Victoria, Di Illio, Chiara, Chambers, Jenny, Kohari, Katherine, Bacq, Yannick, Bozkurt, Nuray, Brun-Furrer, Romana, Bull, Laura, Estiú, Maria C, Grymowicz, Monika, Gunaydin, Berrin, Hague, William M, Haslinger, Christian, Hu, Yayi, Kawakita, Tetsuya, Kebapcilar, Ayse G, Kebapcilar, Levent, Kondrackienė, Jūratė, Koster, Maria P H, Kowalska-Kańka, Aneta, Kupčinskas, Limas, Lee, Richard H, Locatelli, Anna, Macias, Rocio I R, Marschall, Hanns-Ulrich, Oudijk, Martijn A, Raz, Yael, Rimon, Eli, Shan, Dan, Shao, Yong, Tribe, Rachel, Tripodi, Valeria, Yayla Abide, Cigdem, Yenidede, Ilter, Thornton, Jim G, Chappell, Lucy C, Williamson, Catherine“…Eligible studies were case-control, cohort, and population-based studies, and randomised controlled trials, with at least 30 participants, and that reported bile acid concentrations and perinatal outcomes. …”
Publicado 2019
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344835por Liu, Xin, Wu, Tao, Zhu, Su-Yu, Shi, Mei, Su, Hang, Wang, Ying, He, Xia, Xu, Li-Ming, Yuan, Zhi-Yong, Zhang, Li-Ling, Wu, Gang, Qu, Bao-Lin, Qian, Li-Ting, Hou, Xiao-Rong, Zhang, Fu-Quan, Zhang, Yu-Jing, Zhu, Yuan, Cao, Jian-Zhong, Lan, Sheng-Min, Wu, Jun-Xin, Qi, Shu-Nan, Yang, Yong, Li, Ye-Xiong“…These dynamic data appear to provide accurate information on disease processes and continual survival expectations and may help researchers design additional prospective clinical trials and formulate risk-adapted therapies and surveillance strategies.…”
Publicado 2019
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344836por Fischer, Matthieu, Vialleron, Thomas, Laffaye, Guillaume, Fourcade, Paul, Hussein, Tarek, Chèze, Laurence, Deleu, Paul-André, Honeine, Jean-Louis, Yiou, Eric, Delafontaine, Arnaud“…Only randomized controlled trials (RCT) published in English peer-reviewed journals were included. …”
Publicado 2019
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344837por Chen, Yu, Chen, Gang, Li, Jin, Huang, Ying-Ying, Li, Yi, Lin, Jing, Chen, Li-Zhu, Lu, Jian-Ping, Wang, Yu-Qi, Wang, Chang-Xi, Pan, Leong Kin, Xia, Xue-Feng, Yi, Xin, Chen, Chuan-Ben, Zheng, Xiong-Wei, Guo, Zeng-Qing, Pan, Jian-Ji“…DESIGN, SETTING, AND PARTICIPANTS: This multiple-cohort study included patients with NSCLC from the Geneplus Institute, the Cancer Genome Atlas (TCGA), and the Memorial Sloan Kettering Cancer Center (MSKCC) databases and from the POPLAR and OAK randomized controlled trials. Samples in the Geneplus cohort were collected and analyzed from April 30, 2015, through February 28, 2019. …”
Publicado 2019
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344838“…A clearer understanding of how the cells fail to adequately repair the lung and key pathogenetic pathways are much needed and require further exploration. Current clinical trials are studying agents that reduce the fibrotic signalling within the lung, reduce pulmonary hypertension associated with interstitial lung disease, and alleviate oxidative stress. …”
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344839por Ashby, Damien, Borman, Natalie, Burton, James, Corbett, Richard, Davenport, Andrew, Farrington, Ken, Flowers, Katey, Fotheringham, James, Andrea Fox, R. N., Franklin, Gail, Gardiner, Claire, Martin Gerrish, R. N., Greenwood, Sharlene, Hothi, Daljit, Khares, Abdul, Koufaki, Pelagia, Levy, Jeremy, Lindley, Elizabeth, Macdonald, Jamie, Mafrici, Bruno, Mooney, Andrew, Tattersall, James, Tyerman, Kay, Villar, Enric, Wilkie, Martin“…The guideline is split into sections: each begins with a few statements which are graded by strength (1 is a firm recommendation, 2 is more like a sensible suggestion), and the type of research available to back up the statement, ranging from A (good quality trials so we are pretty sure this is right) to D (more like the opinion of experts than known for sure). …”
Publicado 2019
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344840“…In addition, it is also important to assess the role and involvement of patient navigators in research and clinical trials. In total, 82% of the participants when asked agreed to be contacted for participation in research studies. …”
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