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344841por Nic Lochlainn, Laura M, de Gier, Brechje, van der Maas, Nicoline, Strebel, Peter M, Goodman, Tracey, van Binnendijk, Rob S, de Melker, Hester E, Hahné, Susan J M“…We included randomised and quasi-randomised controlled trials, outbreak investigations, and cohort and case-control studies without restriction on publication dates, in which MCV1 was administered to infants younger than 9 months. …”
Publicado 2019
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344842por Carrasco, Joao, Pietsch, Georg-Alexander, Nicolas, Marie-Pierre, Koerber, Cecile, Bennison, Craig, Yoon, Jisu“…INTRODUCTION: Treatment of neovascular age-related macular degeneration (nAMD) has evolved with the advent of anti-vascular endothelial growth factor agents such that intravitreally administered aflibercept and ranibizumab (RBZ) have become the standard of care. Randomized clinical trials (RCTs) have demonstrated the benefits of these agents in nAMD; however, results achieved under RCT protocols may not always be replicated in clinical practice. …”
Publicado 2019
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344843por Marsden, John, White, Martin, Annand, Fizz, Burkinshaw, Peter, Carville, Serena, Eastwood, Brian, Kelleher, Michael, Knight, Jonathan, O'Connor, Rosanna, Tran, Anh, Willey, Peter, Greaves, Felix, Taylor, Stephen“…FINDINGS: 77 articles on the five medicine classes were identified from the literature search and call-for-evidence. 17 randomised placebo-controlled trials (6729 participants) reported antidepressant-associated withdrawal symptoms. …”
Publicado 2019
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344844por Bonfanti, Amanda Pires, Barreto, Natália, Munhoz, Jaqueline, Caballero, Marcus, Cordeiro, Gabriel, Rocha-e-Silva, Thomaz, Sutti, Rafael, Moura, Fernanda, Brunetto, Sérgio, Ramos, Celso Dario, Thomé, Rodolfo, Verinaud, Liana, Rapôso, Catarina“…We aim to synthesize and carry out a formulation with these antineoplastic molecules for clinical trials. Spider venom biomolecules induced smaller and necrotic xenogeneic GB; spider venom activated the innate immune system; venom increased blood monocytes and the migration of macrophages to the tumor; activated PnV-macrophages have a profile different of M1 and have a potential to fight the tumor without promote tumorigenesis.…”
Publicado 2020
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344845por Akinci, Baris, Ajluni, Nevin, Eldin, Abdelwahab Jalal, Swaidan, Mario, Hench, Rita, Neidert, Adam, Luo, Yingying, de Freitas, Maria Cristina Foss, Oral, Elif A“…This study aimed to explore changes in circulating apolipoprotein concentrations, as well as ANGPLT3, ANGPLT4, and IGF-1 levels in patients treated with Metreleptin as part of a clinical study investigating the efficacy of Metreleptin in nonalcoholic steatohepatitis (NASH) associated with partial lipodystrophy (ClinicalTrials.gov identifier: NCT01679197). Methods Serum samples of 18 patients with partial lipodystrophy who underwent a full metabolic evaluation and paired liver biopsies before and after Metreleptin were studied. …”
Publicado 2020
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344846por Hönig, Guillermo, Rodante, Demián, Daray, Federico, Izaguirre, Mercedes, Lenze, Mariela, Valentini, Joaquín, García Bournissen, Facundo, Laura Gutiérrez, María, Wikinski, Silvia“…BACKGROUND: 30% patients suffering from schizophrenia fail to obtain therapeutic benefit even after two appropriate antipsychotic trials and are considered resistant. The recommended treatment in these cases is clozapine (CLZ), but only 40% of patients with resistant schizophrenia show clinical response, a condition called ultra-resistance (UR) and defined as the lack of antipsychotic response after 8 to 12 weeks of treatment with at least 400 mg/day of clozapine or plasma levels ≥ 350 ng/ml. …”
Publicado 2020
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344847“…METHODS AND FINDINGS: PubMed, Ovid Embase, Medline, Web of Science, ClinicalTrials.gov, and Cochrane databases were systematically searched (inception to 12 February 2020). …”
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344848por Coppo, Anna, Bellani, Giacomo, Winterton, Dario, Di Pierro, Michela, Soria, Alessandro, Faverio, Paola, Cairo, Matteo, Mori, Silvia, Messinesi, Grazia, Contro, Ernesto, Bonfanti, Paolo, Benini, Annalisa, Valsecchi, Maria Grazia, Antolini, Laura, Foti, Giuseppe“…This study is registered on ClinicalTrials.gov, NCT04365959, and is now complete. FINDINGS: Between March 20 and April 9, 2020, we enrolled 56 patients, of whom 44 (79%) were male; the mean age was 57·4 years (SD 7·4) and the mean BMI was 27·5 kg/m(2) (3·7). …”
Publicado 2020
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344849“…However, none have gone through clinical trials as they have been found to be highly toxic to human cells. …”
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344850por Götzinger, Florian, Santiago-García, Begoña, Noguera-Julián, Antoni, Lanaspa, Miguel, Lancella, Laura, Calò Carducci, Francesca I, Gabrovska, Natalia, Velizarova, Svetlana, Prunk, Petra, Osterman, Veronika, Krivec, Uros, Lo Vecchio, Andrea, Shingadia, Delane, Soriano-Arandes, Antoni, Melendo, Susana, Lanari, Marcello, Pierantoni, Luca, Wagner, Noémie, L'Huillier, Arnaud G, Heininger, Ulrich, Ritz, Nicole, Bandi, Srini, Krajcar, Nina, Roglić, Srđan, Santos, Mar, Christiaens, Christelle, Creuven, Marine, Buonsenso, Danilo, Welch, Steven B, Bogyi, Matthias, Brinkmann, Folke, Tebruegge, Marc“…METHODS: This multicentre cohort study involved 82 participating health-care institutions across 25 European countries, using a well established research network—the Paediatric Tuberculosis Network European Trials Group (ptbnet)—that mainly comprises paediatric infectious diseases specialists and paediatric pulmonologists. …”
Publicado 2020
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344851por Thein, David, Christiansen, Mia Nielsen, Mogensen, Ulrik Madvig, Bundgaard, Johan Skov, Rørth, Rasmus, Madelaire, Christian, Fosbøl, Emil Loldrup, Schou, Morten, Torp-Pedersen, Christian, Gislason, Gunnar, Køber, Lars, Kristensen, Søren Lund“…BACKGROUND: In randomised clinical trials, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium–glucose cotransporter 2 (SGLT-2) inhibitors reduced cardiovascular events in patients with type 2 diabetes (T2D) at high cardiovascular risk, as compared to standard care. …”
Publicado 2020
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344852por Chen, Feng-Tzu, Etnier, Jennifer L., Chan, Kuei-Hui, Chiu, Ping-Kun, Hung, Tsung-Ming, Chang, Yu-Kai“…OBJECTIVES: This systematic and meta-analytic review of randomized controlled trials (RCTs) investigated the effects of exercise training on EF in older adults and explored potential moderators underlying the effects of exercise training on EF. …”
Publicado 2020
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344853por LeVasseur, Clarissa, Gabrielli, Alexandra, Popchak, Adam, Irrgang, James, Anderst, William, Lin, Albert, Kane, Gillian“…Synchronized biplane radiographs of the shoulder were collected PRE and 1YR-POST at 50 images/s while patients performed 3 trials of scapular plane arm abduction. Six degree of freedom GH and scapular kinematics were determined with sub-millimeter accuracy by matching subject-specific CT-based bone models of the humerus and scapula to radiographs using a validated volumetric tracking technique8. …”
Publicado 2020
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344854por Salam, Rehana A., Padhani, Zahra A., Das, Jai K., Shaikh, Amina Y., Hoodbhoy, Zahra, Jeelani, Sarah Masroor, Lassi, Zohra S., Bhutta, Zulfiqar A.“…We included randomized controlled trials and quasi-experimental studies from both high income countries (HIC) and low-middle-income countries (LMICs). …”
Publicado 2020
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344855por Saghir Afifeh, Arraa M., Verdoia, Monica, Nardin, Matteo, Negro, Federica, Viglione, Filippo, Rolla, Roberta, De Luca, Giuseppe“…Furthermore, we found a significant inverse relationship of calcitriol with inflammatory and metabolic biomarkers, suggesting a potential more relevant and accurate role of calcitriol, as compared to cholecalciferol, in the prediction of cardiovascular risk. Future trials should certainly investigate the potential role of calcitriol administration in the setting of acute coronary syndromes as much as in other inflammatory disorders, such as the SARS-CoV2 infection.…”
Publicado 2021
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344856por Baden, Lindsey R, Stieh, Daniel J, Sarnecki, Michal, Walsh, Stephen R, Tomaras, Georgia D, Kublin, James G, McElrath, M Juliana, Alter, Galit, Ferrari, Guido, Montefiori, David, Mann, Philipp, Nijs, Steven, Callewaert, Katleen, Goepfert, Paul, Edupuganti, Srilatha, Karita, Etienne, Langedijk, Johannes P, Wegmann, Frank, Corey, Lawrence, Pau, Maria G, Barouch, Dan H, Schuitemaker, Hanneke, Tomaka, Frank“…Regimens that use this tetravalent vaccine component are being advanced into field trials to assess efficacy against HIV-1 infection. …”
Publicado 2020
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344857por Peahl, Alex F., Powell, Allison, Berlin, Hanna, Smith, Roger D., Krans, Elizabeth, Waljee, Jennifer, Dalton, Vanessa K., Heisler, Michele, Moniz, Michelle H.“…BACKGROUND: Randomized controlled trials document the safety and efficacy of reduced frequency prenatal visit schedules and virtual visits, but real-world data are lacking. …”
Publicado 2021
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344858Publicado 2020“…This method has six analytical steps. (1) We included 560 risk–outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk–outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk–outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. …”
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344859“…Since this first report, further clinical trials are underway investigating the efficacy and tolerability of IL-6 antagonists in patients with COVID-19 disease. …”
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344860por Dickson, Jennifer L, Hall, Helen, Horst, Carolyn, Tisi, Sophie, Verghese, Priyam, Mullin, Anne-Marie, Teague, Jon, Farrelly, Laura, Bowyer, Vicky, Gyertson, Kylie, Bojang, Fanta, Levermore, Claire, Anastasiadis, Tania, McCabe, John, Navani, Neal, Nair, Arjun, Devaraj, Anand, Hackshaw, Allan, Quaife, Samantha L, Janes, Sam M“…This study was registered prospectively with ClinicalTrials.gov, NCT03934866. FINDINGS: Between March 20 and Dec 12, 2019, the records of 2 333 488 individuals from 251 primary care practices across northeast and north-central London were screened for eligibility; 1 974 919 (84·6%) individuals were outside the eligible age range, 7578 (2·1%) had pre-existing medical conditions, and 11 962 (3·3%) had opted out of particpation in research and thus were not invited. 95 297 individuals were eligible for invitation, of whom 29 545 (31·0%) responded. …”
Publicado 2023
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