“…This study is registered with ClinicalTrials.gov, NCT04089436, and is now complete. FINDINGS: Between July 28, 2014, and Dec 31, 2017, 664 children with encephalitis were enrolled. …”
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“…This study is registered at ClinicalTrials.gov (NCT04786353). FINDINGS: Responses to the survey were received from 10 997 (28·8%) of 38 152 cases and 33 016 (22·4%) of 147 212 controls between July 20, 2021, and Sept 15, 2021. …”
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“…BACKGROUND: Direct evaluation of vascular inflammation in patients with COVID-19 would facilitate more efficient trials of new treatments and identify patients at risk of long-term complications who might respond to treatment. …”
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“…The study is registered at ClinicalTrials.gov, NCT05186597. FINDINGS: Among 310 423 Danish children aged younger than 5 years, the mean number of RSV-associated hospital admissions increased from 1477 (SD 226) in the 2016–17 to 2019–20 RSV seasons to 3000 in the 2021–22 RSV season (RR 2·0 [95% CI 1·9–2·1]). 54 children with RSV received mechanical ventilation in 2021–22 compared with 15–28 annually in the 2016–17 to 2019–20 RSV seasons (2·3 [1·6–3·3]). …”
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“…METHOD: We conducted a prospective pilot study (ClinicalTrials.gov 2021-6656) of HIV mono-infected patients undergoing metabolic characterization and paired CAP by transient elastography with dual-energy X-ray absorptiometry (DEXA) scan. …”
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“…The OnCovid study is registered in ClinicalTrials.gov, NCT04393974. FINDINGS: 2795 patients diagnosed with SARS-CoV-2 infection between Feb 27, 2020, and Feb 14, 2021, were entered into the study by the time of the data lock on March 1, 2021. …”
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“…The MYCOVID study is registered with ClinicalTrials.gov, NCT04368221. FINDINGS: Between Feb 29 and July 9, 2020, we enrolled 565 mechanically ventilated patients with COVID-19. 509 patients with at least three screening samples were analysed (mean age 59·4 years [SD 12·5], 400 [79%] men). 128 (25%) patients had 138 episodes of pr/pb or possible IFIs. 76 (15%) patients fulfilled the criteria for pr/pb CAPA. …”
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“…Part IBiomaterials ScienceBiomaterials Science and EngineeringLearning ObjectivesMaterials Science and EngineeringMultilevels of Structure and Categorization of MaterialsFour Categories of MaterialsDefinitions of Biomaterials, Biomedical Materials, and Biological MaterialsBiocompatibilityChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyToxicity and CorrosionLearning ObjectivesElements in the BodyBiological Roles and Toxicities of Trace ElementsSelection of Metallic Elements in Medical-Grade AlloysCorrosion of MetalsEnvironment inside the BodyMinimization of Toxicity of Metal ImplantsChapter HighlightsLaboratory Practice 1Simple Questions in ClassProblems and ExercisesAdvanced Topic: Biological Roles of Alloying ElementsBibliographyMechanical Properties of BiomaterialsLearning ObjectivesRole of Implant BiomaterialsMechanical Properties of General ImportanceHardnessElasticity: Resilience and StrechabilityMechanical Properties Terms Used in the Medical CommunityFailureEssential Mechanical Properties of Orthopedic Implant BiomaterialsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyMetallic Biomaterials in Orthopedic ImplantsLearning ObjectivesDevelopment of Metallic BiomaterialsStainless SteelsCobalt-Based AlloysTitanium AlloysComparison of Stainless Steels, Cobalt, and Titanium AlloysSummary and RemarksChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyMetallic Biomaterials: Miscellaneous OthersLearning ObjectivesDental MaterialsNiTi Shape-Memory AlloysOther Clinically Applied Metallic MaterialsNew Metallic Materials: Magnesium AlloysChapter HighlightsLaboratory Practice 2Simple Questions in ClassProblems and ExercisesBibliographyBioinert CeramicsLearning ObjectivesOverview of BioceramicsInert Bioceramics: Al2O3Inert Bioceramics: ZrO2Two Types of JointsSummary and Remarks on Al2O3 and ZrO2Dental CeramicsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesAdvanced Topic: Total Joint ReplacementBibliographyBioactive and Bioresorbable CeramicsLearning ObjectivesOverview of Surface Bioactive and Bulk Degradable CeramicsCalcium Phosphates and HydroxyapatiteBioactive GlassesBioactive Glass-CeramicsBone-Bonding MechanismsBiodegradable CeramicsChapter HighlightsLaboratory Practice 3Simple Questions in ClassProblems and ExercisesAdvanced Topic: Bioceramic Scaffolds for Bone Tissue EngineeringBibliographyPolymeric Biomaterials: FundamentalsLearning ObjectivesBasic Concepts on PolymersOverview of Polymeric BiomaterialsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesAdvanced Topic: Polymers and Polymer Scaffolds for Soft Tissue EngineeringBibliographyBioinert PolymersLearning ObjectivesPolyolefinPoly(Ethylene Terephthalate)Acrylate PolymerFluorocarbon PolymersSiliconePolyurethaneChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesAdvanced Topic: Properties and Applications of Polyurethane as BiomaterialsBibliographyBioresorbable PolymersLearning ObjectivesBiodegradation of PolymersPolyesters: PGA, PLA, and PCLPolyesters: PHAElastomeric Polyester: Poly(Polyol Sebacate)Polyether: Poly(Ethylene Glycol)PolyamideSurface-Erodible PolymersBiological PolymersChapter HighlightsSimple Questions in ClassProblems and ExercisesLaboratory Practice 4Advanced Topic: Natural Polymers: Resilin, Silk, and GlutenBibliographyComposite BiomaterialsLearning ObjectivesOverview of CompositesNatural Composites: BoneDental CompositesArtificial BoneChapter HighlightsLaboratory Practice 5Simple Questions in ClassProblems and ExercisesAdvanced Topic: Development of Artificial Bone: Composites and ScaffoldsBibliographyPart IIMedical ScienceMedicine and Medical ScienceLearning ObjectivesMedicine and Medical ScienceMedical Science versus Materials ScienceLearning Goals of Part IIChapter HighlightsActivityBibliographyImage LinksSimple Questions in ClassProblems and ExercisesHuman Anatomy And Diseases I: Integumentary, Skeletal, Muscular, Nervous, and Endocrine SystemsLearning ObjectivesIntegumentary SystemSkeletal SystemMuscular SystemNervous SystemEndocrine SystemChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesAdvanced Topic: Biomaterial Challenges in Bone Tissue EngineeringBibliographyHuman Anatomy And Diseases II: Cardiovascular SystemLearning ObjectivesAnatomy and Functions of the Cardiovascular SystemCardiovascular DiseaseCardiac Performance: P-V LoopCurrent Therapies for Heart DiseaseAlternative Treatments and Application of BiomaterialsArtificial Blood VesselsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyHuman Anatomy And Diseases III: Respiratory, Lymphatic, Digestive, Urinary, and Reproductive SystemsLearning ObjectivesRespiratory SystemLymphatic SystemDigestive SystemUrinary SystemReproductive SystemChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyCells and BiomoleculesLearning ObjectivesIntroductionCell Biochemistry and BiosynthesisCell StructureTransport across Plasma MembranesCell ProliferationCell Differentiation and Stem CellsChapter HighlightsActivitiesAdvanced Topic: Cell Therapy to Treat Cardiac DiseaseStrategies to Address Immune Rejection in CellsSummary of Cell-Based Therapies and Their LimitationsSimple Questions in ClassProblems and ExercisesBibliographyHistology and Tissue Properties I: Epithelial, Neuronal, and Muscle TissueLearning ObjectivesIntroductionEpitheliumMuscular TissueNervous TissueChapter HighlightsActivitiesAdvanced Topic: Properties of Proteins in Mammalian TissuesSimple Questions in ClassProblems and ExercisesBibliographyHistology and Tissue Properties II: Connective TissuesLearning ObjectivesOverview of Connective TissuesTypes of Connective TissueConnective Tissue Proper (Skin, Tendon, Ligament)Mechanical Properties of Structural ProteinsCartilageBoneChapter HighlightsLaboratory Practice 6Simple Questions in ClassProblems and ExercisesBibliographyImmune System and Body Responses to BiomaterialsLearning ObjectivesImmune SystemTissue Response to InjuriesBody Response to ImplantsChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyEvaluation of BiomaterialsLearning ObjectivesOverview of Biomaterials EvaluationStandardsToxicological EvaluationCytotoxicity TestingEvaluation in AnimalsChapter HighlightsLaboratory Practice 7Case Study: Evaluation of Heart Patch in RatsSimple Questions in ClassProblems and ExercisesBibliographyRegulation of Medical DevicesLearning ObjectivesRegulations versus StandardsMedical DevicesPreclinical TestingClinical TrialsDevelopment of Medical Devices and Possible Career OpportunitiesChapter HighlightsActivitiesSimple Questions in ClassProblems and ExercisesBibliographyIndex.…”
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“…Safety data suggested no increased risk of serious adverse events (risk ratio [RR] 0·83 [95% CI 0·21–3·33]; two randomised controlled trials; CoE low), with approximately 0·23–1·2 events per 100 000 administered vaccines reported in real-life observations. …”
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“…MATÉRIELS ET MÉTHODES: Il s'agit d'une sous-étude de l'étude ANRS0001S COV-POPART (ClinicalTrials.gov NCT04824651), cohorte nationale évaluant l'immunogénicité de la vaccination COVID-19 en populations particulières. …”
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“…Study design: We included randomised controlled trials (RCTs), quasi‐experimental studies (QES), and two‐group comparison designs. …”
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“…Method: Randomized controlled trials (RCTs) of NDQG for DKD from Chinese and English databases up to 31 August 2022 were included. …”
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“…Anabolic effects from cytokines concentrated in Leukocyte-Poor configurations of PRP (LP-PRP) are hypothesized to inhibit the native catabolic environment of the cartilage degeneration process. Multiple Level I trials comparing LP- PRP to hyaluronic acid and placebo injections have shown LP-PRP to improve patient symptoms from early knee OA for up to 1 year. …”
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“…The 2011 review included the following atypical antipsychotics: aripiprazole, olanzapine, quetiapine, risperidone, and ziprasidone; no clinical trials were found for off-label use of the 3 most recently FDA-approved atypical antipsychotics (asenapine, iloperidone, and paliperidone). …”
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“…INTERVENTION(S): The PubMed, MEDLINE, and EMBASE databases and the Cochrane Central Register of Controlled Trials (CCRT) were searched from 1983 to October 2022. …”
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“…Translation was facilitated by her daughter, who explained that previous trials of methotrexate had not been tolerated due to gastrointestinal side effects. …”
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“…Background: LUM-201 is an investigational oral GH secretagogue (GHS) currently in 3 Phase 2 iPGHD trials. The LUM-201 predictive enrichment marker (PEM) may be used to identify patients previously diagnosed with iPGHD who are likely to respond to LUM-201. …”
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“…METHODS: Randomized controlled trials focusing on EGFR-TKIs (alone or in combination) in advanced and EGFR-mutant NSCLC patients, who have not received systematic treatment, were systematically searched up to December 2021. …”
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“…This project highlights the utility of CURE ID in using real-world data to identify signals of drug repurposing where traditional efficacy trials cannot be conducted. Antibiotics used to treat Nonvenereal Treponemal infections [Figure: see text] Penicillin was the most frequently used antibiotic class in 11/13 (84.61%), 30/37 (81.08%), and 3/3 (100%) of Bejel, Yaws, and Pinta respectively. …”
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“…Such biomarkers merit evaluation in clinical trials. Bioinformatics drug repurposing analyses with the gene expression biosignatures of the Top Dozen and Bonferroni-validated universal biomarkers identified novel potential therapeutics for suicidality, such as ebselen (a lithium mimetic), piracetam (a nootropic), chlorogenic acid (a polyphenol) and metformin (an antidiabetic and possible longevity promoting drug). …”
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