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  1. 345041
    “…Conclusions Patients with hematologic diseases have lower serological response rates to SARS-CoV-2 vaccines than those previously reported in clinical trials. Our results also suggest they benefit from receiving both doses with no significant difference between vaccine types. …”
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    Serologic Responses Following Sars-Cov-2 Vaccination and Factors Influencing It in Patients with Hematological Malignant and Non-Malignant Diseases - a Prospective Multicentric Study
  2. 345042
    “…However, most SARS-CoV-2 vaccine trials required pts to be off immune suppression to be eligible and therefore excluded most pts with hematologic malignancies. …”
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    COVID Vaccine Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Better Antibody Response in Patients with Myeloid Malignancies Than B-Cell Malignancies
  3. 345043
    “…Further explorations are needed with focus on potential risk of COVID infections despite full vaccination: The potential of 3 (rd) booster vaccination should be explored within clinical trials. DISCLOSURES: Reiter:  AOP Orphan Pharmaceuticals: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: travel support; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Travel expenses, Research Funding; Celgene/BMS: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: travel support; Incyte: Membership on an entity's Board of Directors or advisory committees, Other: Travel expenses; Blueprint Medicines: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Travel expenses; Abbvie: Membership on an entity's Board of Directors or advisory committees; Deciphera: Membership on an entity's Board of Directors or advisory committees, Other: Travel expenses. …”
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    Antibody Response to Vaccination with BNT162b2, mRNA-1273, and ChADOx1 in Patients with Myeloid and Lymphoid Neoplasms
  4. 345044
    “…SELECTION CRITERIA: We included randomised controlled trials (RCTs) in which people who smoked cigarettes were randomised to switch to exclusive HTP use or a control condition. …”
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    Heated tobacco products for smoking cessation and reducing smoking prevalence
  5. 345045
    “…SELECTION CRITERIA: We included cluster‐randomized controlled trials (cRCTs), interrupted time series (ITS), or controlled before‐after studies (CBAs) comparing IRS plus ITNs with ITNs alone. …”
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    Indoor residual spraying for preventing malaria in communities using insecticide‐treated nets
  6. 345046
    “…This highlights the necessity for clinical trials looking into the efficacy of different immunosuppressants on patient outcomes. …”
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    P31 Cogan's syndrome—a neglected autoimmune vasculitis
  7. 345047
    “…The highest risk is associated with history of arterial thrombosis and those with triple positive antibody status. Three clinical trials have either been completed or are in the process of investigating whether NOACs sufficiently prevent thromboembolic disease in these patients. …”
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    O25 Catastrophic antiphospholipid crisis triggered by anticoagulant switch
  8. 345048
    por Dhana, Ashar, Hamada, Yohhei, Kengne, Andre P, Kerkhoff, Andrew D, Rangaka, Molebogeng X, Kredo, Tamara, Baddeley, Annabel, Miller, Cecily, Singh, Satvinder, Hanifa, Yasmeen, Grant, Alison D, Fielding, Katherine, Affolabi, Dissou, Merle, Corinne S, Wachinou, Ablo Prudence, Yoon, Christina, Cattamanchi, Adithya, Hoffmann, Christopher J, Martinson, Neil, Mbu, Eyongetah Tabenyang, Sander, Melissa S, Balcha, Taye T, Skogmar, Sten, Reeve, Byron W P, Theron, Grant, Ndlangalavu, Gcobisa, Modi, Surbhi, Cavanaugh, Joseph, Swindells, Susan, Chaisson, Richard E, Ahmad Khan, Faiz, Howard, Andrea A, Wood, Robin, Thit, Swe Swe, Kyi, Mar Mar, Hanson, Josh, Drain, Paul K, Shapiro, Adrienne E, Kufa, Tendesayi, Churchyard, Gavin, Nguyen, Duc T, Graviss, Edward A, Bjerrum, Stephanie, Johansen, Isik S, Gersh, Jill K, Horne, David J, LaCourse, Sylvia M, Al-Darraji, Haider Abdulrazzaq Abed, Kamarulzaman, Adeeba, Kempker, Russell R, Tukvadze, Nestani, Barr, David A, Meintjes, Graeme, Maartens, Gary
    Publicado 2022
    “…We included prospective cross-sectional, observational studies and randomised trials among adult and adolescent (age ≥10 years) ambulatory people living with HIV, irrespective of signs and symptoms of tuberculosis. …”
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    Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis
  9. 345049
    “…MATÉRIELS ET MÉTHODES: Il s'agit d'une sous-étude nichée dans l'étude ANRS0001S COV-POPART (ClinicalTrials.gov NCT04824651), cohorte nationale française évaluant l'immunogénicité de la vaccination COVID-19 dans des populations particulières. …”
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    Évaluation de l'immunogénicité après vaccination COVID-19 hétérologue ChAdOx1-nCoV19/BNT162b2 et homologue BNT162b2/BNT162b2– Cohorte ANRS0001S COV-POPART
  10. 345050
    por Pinato, David J, Aguilar-Company, Juan, Ferrante, Daniela, Hanbury, Georgina, Bower, Mark, Salazar, Ramon, Mirallas, Oriol, Sureda, Anna, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Townsend, Sarah, Jackson, Amanda, Dalla Pria, Alessia, Newsom-Davis, Thomas, Handford, Jasmine, Sita-Lumsden, Ailsa, Apthorp, Eleanor, Vincenzi, Bruno, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo, Biello, Federica, Sinclair, Alasdair, Bawany, Samira, Khalique, Saira, Rossi, Sabrina, Rogers, Lucy, Murphy, Cian, Belessiotis, Katherine, Carmona-García, M Carmen, Sharkey, Rachel, García-Illescas, David, Rizzo, Gianpiero, Perachino, Marta, Saoudi-Gonzalez, Nadia, Doonga, Kris, Fox, Laura, Roldán, Elisa, Gaidano, Gianluca, Ruiz-Camps, Isabel, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Cantini, Luca, Zambelli, Alberto, Giusti, Raffaele, Mazzoni, Francesca, Caliman, Enrico, Santoro, Armando, Grosso, Federica, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Prat, Aleix, Tucci, Marco, Libertini, Michela, Grisanti, Salvatore, Mukherjee, Uma, Diamantis, Nikolaos, Fusco, Vittorio, Generali, Daniele, Provenzano, Salvatore, Gennari, Alessandra, Tabernero, Josep, Cortellini, Alessio
    Publicado 2022
    “…This study is registered with ClinicalTrials.gov, NCT04393974, and is ongoing. FINDINGS: As of Feb 4, 2022 (database lock), the registry included 3820 patients who had been diagnosed with COVID-19 between Feb 27, 2020, and Jan 31, 2022. 3473 patients were eligible for inclusion (1640 [47·4%] were women and 1822 [52·6%] were men, with a median age of 68 years [IQR 57–77]). 2033 (58·5%) of 3473 were diagnosed during the prevaccination phase, 1075 (31·0%) during the alpha-delta phase, and 365 (10·5%) during the omicron phase. …”
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    Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study
  11. 345051
    “…Peak knee extension moment (Nm/Ht*Wt) and total knee joint power (Watt/Ht*Wt) as a measure of eccentric loading (contraction) during the descent phase of a single-leg squat were calculated on the surgical limb and averaged across the middle three trials. Participants also completed quadriceps strength testing on both limbs (surgical and non-surgical) on an isokinetic dynamometer at 60 °/sec. …”
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    Paper 84: Differences in Metrics of Knee Joint Loading Between Individuals Following a Primary Anterior Cruciate Ligament Repair (ACL-R) Surgery Versus Those Who Underwent a Standard ACL Reconstruction with a Patella Bone-Tendon-Bone Autograft (ACLR)
  12. 345052
    “…Other treatments can be used, but there is a paucity of data from clinical trials as to what treatment should be used and in what order. …”
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    P47 The conundrums of Macrophage activation syndrome (MAS) - when to consider a Haematopoietic Stem Cell Transplant (HSCT)
  13. 345053
    “…METHODS: In CRACKLE-2, patients with CPEc were enrolled from 26 hospitals in 6 countries (ClinicalTrials.gov NCT03646227). Clinical data were collected, and bacterial isolates underwent whole genome sequencing (WGS). …”
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    229. Molecular and Clinical Epidemiology of Carbapenemase-Producing E. coli Isolates from Different Global Regions (CRACKLE-2)
  14. 345054
    “…We identified 26 systematic reviews, 236 quantitative comparative studies (of which 38 were randomised controlled trials), 227 were qualitative studies (or had a qualitative element), 105 were observational studies (or had elements of observational methods) and 82 used a mixed methods approach. …”
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    Non‐familial intergenerational interventions and their impact on social and mental wellbeing of both younger and older people—A mapping review and evidence and gap map
  15. 345055
    por Moore, Katrina M, Nicholas, Jennifer, Grossman, Murray, McMillan, Corey T, Irwin, David J, Massimo, Lauren, Van Deerlin, Vivianna M, Warren, Jason D, Fox, Nick C, Rossor, Martin N, Mead, Simon, Bocchetta, Martina, Boeve, Bradley F, Knopman, David S, Graff-Radford, Neill R, Forsberg, Leah K, Rademakers, Rosa, Wszolek, Zbigniew K, van Swieten, John C, Jiskoot, Lize C, Meeter, Lieke H, Dopper, Elise GP, Papma, Janne M, Snowden, Julie S, Saxon, Jennifer, Jones, Matthew, Pickering-Brown, Stuart, Le Ber, Isabelle, Camuzat, Agnès, Brice, Alexis, Caroppo, Paola, Ghidoni, Roberta, Pievani, Michela, Benussi, Luisa, Binetti, Giuliano, Dickerson, Bradford C, Lucente, Diane, Krivensky, Samantha, Graff, Caroline, Öijerstedt, Linn, Fallström, Marie, Thonberg, Håkan, Ghoshal, Nupur, Morris, John C, Borroni, Barbara, Benussi, Alberto, Padovani, Alessandro, Galimberti, Daniela, Scarpini, Elio, Fumagalli, Giorgio G, Mackenzie, Ian R, Hsiung, Ging-Yuek R, Sengdy, Pheth, Boxer, Adam L, Rosen, Howie, Taylor, Joanne B, Synofzik, Matthis, Wilke, Carlo, Sulzer, Patricia, Hodges, John R, Halliday, Glenda, Kwok, John, Sanchez-Valle, Raquel, Lladó, Albert, Borrego-Ecija, Sergi, Santana, Isabel, Almeida, Maria Rosário, Tábuas-Pereira, Miguel, Moreno, Fermin, Barandiaran, Myriam, Indakoetxea, Begoña, Levin, Johannes, Danek, Adrian, Rowe, James B, Cope, Thomas E, Otto, Markus, Anderl-Straub, Sarah, de Mendonça, Alexandre, Maruta, Carolina, Masellis, Mario, Black, Sandra E, Couratier, Philippe, Lautrette, Geraldine, Huey, Edward D, Sorbi, Sandro, Nacmias, Benedetta, Laforce, Robert, Tremblay, Marie-Pier L, Vandenberghe, Rik, Van Damme, Philip, Rogalski, Emily J, Weintraub, Sandra, Gerhard, Alexander, Onyike, Chiadi U, Ducharme, Simon, Papageorgiou, Sokratis G, Lyn, Adeline Su, Brodtmann, Amy, Finger, Elizabeth, Guerreiro, Rita, Bras, Jose, Rohrer, Jonathan D
    Publicado 2019
    “…Although estimation of age at onset will be an important factor in future pre-symptomatic therapeutic trials for all three genetic groups, our study suggests that data from other members of the family will be particularly helpful only for individuals with MAPT mutations. …”
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    Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
  16. 345056
    “…MAIN RESULTS: We included 16 Cochrane Reviews, corresponding to 138 randomised clinical trials (RCT) and 11,856 preterm infants, on the prevention and treatment of PDA in preterm infants. …”
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    Interventions for patent ductus arteriosus (PDA) in preterm infants: an overview of Cochrane Systematic Reviews
  17. 345057
    “…S.B. reports speakers’ fees from Merck, Organon, Ferring, the Ostetric and Gynaecological Society of Singapore and the Taiwanese Society for Reproductive Medicine; editor and contributing author, Reproductive Medicine for the MRCOG, Cambridge University Press; is part of the METAFOR and CAPE trials data monitoring committee. E.B. reports research grants from Roche diagnostics, Gedeon Richter and IBSA; speaker’s fees from Merck, Ferring, MSD, Roche Diagnostics, Gedeon Richter, IBSA; E.B. is also a part of an Advisory Board of Ferring Pharmaceuticals, MSD, Roche Diagnostics, IBSA, Merck, Abbott and Gedeon Richter. …”
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    Evidence-based guideline: unexplained infertility
  18. 345058
    “…SEARCH METHODS: In January 2022, we searched CENTRAL, MEDLINE, Embase, 12 other databases and three trials registers. We also checked reference lists of included studies, contacted authors and experts, and ran forward citation searches. …”
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    Psychosocial interventions for survivors of rape and sexual assault experienced during adulthood
  19. 345059
    “…BACKGROUND: Several randomized controlled trials (RCT) have shown that short-course (∼7 days) antibiotic treatment is non-inferior to longer antibiotic courses (∼14 days) in patients with uncomplicated bloodstream infection (BSI) with mostly susceptible Gram-negative bacteria. …”
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    215. Shorter vs. Longer Duration of Treatment in Patients with Ceftriaxone-resistant and Ceftriaxone-susceptible Escherichia coli Bloodstream Infections
  20. 345060
    “…Funding sources for physician-scientists at OHSU were more diverse than for Ph.D. scientists, and physician-scientists comprise the majority of Principal Investigators on clinical trials. These non-RPG sources of funding remain a critical source of support, although local analyses of time spent on research indicate that physician-scientists with NIH funding spend a greater percentage of their time on research than those without. …”
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    2237 From bedside to benchmarks: A physician-scientist workforce dashboard for biomedical research institutions
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