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345061por Vonasek, Bryan, Ness, Tara, Takwoingi, Yemisi, Kay, Alexander W, Wyk, Susanna S, Ouellette, Lara, Marais, Ben J, Steingart, Karen R, Mandalakas, Anna M“…SEARCH METHODS: We searched six databases, including the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase, on 14 February 2020 without language restrictions and contacted researchers in the field. …”
Publicado 2021
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345062por Imdad, Aamer, Rehman, Faseeha, Davis, Evans, Ranjit, Deepika, Surin, Gamael S. S., Attia, Suzanna L., Lawler, Sarah, Smith, Abigail A., Bhutta, Zulfiqar A.“…SEARCH METHODS: We conducted electronic searches for relevant studies on the following databases: PubMed, CINAHL, LILACS, SCOPUS, and CENTRAL, Cochrane Central Register for Controlled Trials, up to November 27, 2019. SELECTION CRITERIA: We aimed to include randomized and quasi‐experimental studies. …”
Publicado 2021
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345063por Aikawa, Nadia E, Kupa, Leonard V K, Pasoto, Sandra G, Medeiros-Ribeiro, Ana C, Yuki, Emily F N, Saad, Carla G S, Pedrosa, Tatiana, Fuller, Ricardo, Shinjo, Samuel K, Sampaio-Barros, Percival D, Andrade, Danieli C O, Pereira, Rosa M R, Seguro, Luciana P C, Valim, Juliana M L, Waridel, Filipe, Sartori, Ana Marli C, Duarte, Alberto J S, Antonangelo, Leila, Sabino, Ester C, Menezes, Paulo Rossi, Kallas, Esper G, Silva, Clovis A, Bonfa, Eloisa“…This study is registered with ClinicalTrials.gov, NCT04754698, and is ongoing for long-term immunogenicity evaluation. …”
Publicado 2022
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345064por Daar, Eric, Orkin, Chloe, Sax, Paul, Stephens, Jeffrey L, Koenig, Ellen, Clarke, Amanda, Baumgarten, Axel, Brinson, Cynthia, Ramgopal, Moti, Huang, Hailin, Farrow, Terry, Baeten, Jared, Hindman, Jason, Martin, Hal, Workowski, Kimberly“…Here we present longer-term follow up on incidence of DM, hypertension (HTN), BMI categorical shifts, and lipid changes over 144 weeks of blinded treatment from two trials of PWH initiating antiretroviral therapy. METHODS: We assessed incidence of metabolic complications in adult PWH in Study 1489: bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) vs dolutegravir/abacavir/ lamivudine (DTG/ABC/3TC) and Study 1490: B/F/TAF vs DTG+F/TAF. …”
Publicado 2021
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345065“…Patients of high-risk groups and with recurrent events should receive indefinite anticoagulant. Several major trials of DOACs failed to reach primary efficacy and safety endpoints, in particular rivaroxaban, hence these should be avoided particularly in arterial thrombosis. …”
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345066por Martinez, Alejandro Morales, Caliva, Francesco, Pedoia, Valentina, Lansdown, Drew, Namiri, Nikan“…METHODS: Subjects: We obtained data from the Osteoarthritis Initiative (OAI), a multi-institutional study conducted between 2005 and 2006, consisting of 4796 participants aged 45 to 80 years (NCT#00080171, on ClinicalTrials.gov). Eligible participants had osteoarthritis (OA) or elevated risk of OA in at least one knee at baseline. …”
Publicado 2022
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345067“…However, most anti-TNFα treatments in clinical trials with antibodies or inhibitors to reduce inflammation in OA have yielded conflicting results (2). …”
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345068por Menzin, Joseph, Korn, Jonathan R., Cohen, Joseph, Lobo, Francis, Zhang, Bin, Friedman, Mark, Newmann, Peter J.“…Findings from randomized clinical trials have shown that improved glycemic control may reduce the risk of long-term complications as long as a target for hemoglobin A1c is not set below 7% for intensive glycemic control. …”
Publicado 2010
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345069por Lindson, Nicola, Theodoulou, Annika, Ordóñez-Mena, José M, Fanshawe, Thomas R, Sutton, Alex J, Livingstone-Banks, Jonathan, Hajizadeh, Anisa, Zhu, Sufen, Aveyard, Paul, Freeman, Suzanne C, Agrawal, Sanjay, Hartmann-Boyce, Jamie“…SELECTION CRITERIA: We included randomised controlled trials (RCTs), cluster‐RCTs and factorial RCTs, which measured smoking cessation at six months or longer, recruited adults who smoked combustible cigarettes at enrolment (excluding pregnant people) and randomised them to approved pharmacotherapies and technologies used for smoking cessation worldwide (varenicline, cytisine, nortriptyline, bupropion, nicotine replacement therapy (NRT) and e‐cigarettes) versus no pharmacological intervention, placebo (control) or another approved pharmacotherapy. …”
Publicado 2023
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345070por Theron, Grant, Peter, Jonny, Richardson, Marty, Warren, Rob, Dheda, Keertan, Steingart, Karen R“…SEARCH METHODS: We searched the following databases without language restrictions up to 21 September 2015: the Cochrane Infectious Diseases Group Specialized Register; MEDLINE; Embase OVID; Science Citation Index Expanded, Conference Proceedings Citation Index‐Science, and BIOSIS Previews (all three from Web of Science); LILACS; and SCOPUS; registers for ongoing trials; and ProQuest Dissertations & Theses A&I. We reviewed references from included studies and contacted specialists in the field. …”
Publicado 2016
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345071por Li, Jian, Pega, Frank, Ujita, Yuka, Brisson, Chantal, Clays, Els, Descatha, Alexis, Ferrario, Marco M., Godderis, Lode, Iavicoli, Sergio, Landsbergis, Paul A., Metzendorf, Maria-Inti, Morgan, Rebecca L., Pachito, Daniela V., Pikhart, Hynek, Richter, Bernd, Roncaioli, Mattia, Rugulies, Reiner, Schnall, Peter L., Sembajwe, Grace, Trudel, Xavier, Tsutsumi, Akizumi, Woodruff, Tracey J., Siegrist, Johannes“…We included randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies which contained an estimate of the effect of exposure to long working hours (41–48, 49–54 and ≥55 h/week), compared with exposure to standard working hours (35–40 h/week), on IHD (prevalence, incidence or mortality). …”
Publicado 2020
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345072por Flower, Luke, Gale, Aislinn, Elfar, Eman, Manson, Jessica, Tattersal, Rachel, Quick, Vanessa“…Optimal treatment for sHLH and the hyperinflammatory syndromes associated with COVID-19 is not supported by randomised controlled trials but there is accumulating evidence for anakinra. …”
Publicado 2020
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345073por Shi, Chunhu, Dumville, Jo C, Cullum, Nicky, Rhodes, Sarah, McInnes, Elizabeth, Goh, En Lin, Norman, Gill“…Where possible, we included the randomised controlled trials from each included review in network meta‐analyses. …”
Publicado 2021
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345074por Bancroft, Elizabeth K, Page, Elizabeth C, Brook, Mark N, Thomas, Sarah, Taylor, Natalie, Pope, Jennifer, McHugh, Jana, Jones, Ann-Britt, Karlsson, Questa, Merson, Susan, Ong, Kai Ren, Hoffman, Jonathan, Huber, Camilla, Maehle, Lovise, Grindedal, Eli Marie, Stormorken, Astrid, Evans, D Gareth, Rothwell, Jeanette, Lalloo, Fiona, Brady, Angela F, Bartlett, Marion, Snape, Katie, Hanson, Helen, James, Paul, McKinley, Joanne, Mascarenhas, Lyon, Syngal, Sapna, Ukaegbu, Chinedu, Side, Lucy, Thomas, Tessy, Barwell, Julian, Teixeira, Manuel R, Izatt, Louise, Suri, Mohnish, Macrae, Finlay A, Poplawski, Nicola, Chen-Shtoyerman, Rakefet, Ahmed, Munaza, Musgrave, Hannah, Nicolai, Nicola, Greenhalgh, Lynn, Brewer, Carole, Pachter, Nicholas, Spigelman, Allan D, Azzabi, Ashraf, Helfand, Brian T, Halliday, Dorothy, Buys, Saundra, Ramon y Cajal, Teresa, Donaldson, Alan, Cooney, Kathleen A, Harris, Marion, McGrath, John, Davidson, Rosemarie, Taylor, Amy, Cooke, Peter, Myhill, Kathryn, Hogben, Matthew, Aaronson, Neil K, Ardern-Jones, Audrey, Bangma, Chris H, Castro, Elena, Dearnaley, David, Dias, Alexander, Dudderidge, Tim, Eccles, Diana M, Green, Kate, Eyfjord, Jorunn, Falconer, Alison, Foster, Christopher S, Gronberg, Henrik, Hamdy, Freddie C, Johannsson, Oskar, Khoo, Vincent, Lilja, Hans, Lindeman, Geoffrey J, Lubinski, Jan, Axcrona, Karol, Mikropoulos, Christos, Mitra, Anita V, Moynihan, Clare, Ni Raghallaigh, Holly, Rennert, Gad, Collier, Rebecca, Offman, Judith, Kote-Jarai, Zsofia, Eeles, Rosalind A“…This study is registered with ClinicalTrials.gov, NCT00261456, and is now closed to accrual. …”
Publicado 2021
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345075por Tohidi-Esfahani, Ibrahim, Warden, Andrew, Malunis, Elena, deNardis, Peter Liburdi, Postek, Michelle, D'Sa, Shirley, Kersten, Marie José, Thomas, Sheeba K, Palomba, M. Lia, Olszewski, Adam J., Guerin, Newton, Scott, Clare, Trotman, Judith“…Introduction: WhiMSICAL (Waldenström's Macroglobulinemia Study Involving CArt-wheeL) is the first global Waldenström's Macroglobulinemia (WM) registry capturing patient-derived data to complement scarce clinical trials data in this rare cancer (Tohidi-Esfahani et al, Am J Hematol 2021). …”
Publicado 2021
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345076por Becker, Christian M, Bokor, Attila, Heikinheimo, Oskari, Horne, Andrew, Jansen, Femke, Kiesel, Ludwig, King, Kathleen, Kvaskoff, Marina, Nap, Annemiek, Petersen, Katrine, Saridogan, Ertan, Tomassetti, Carla, van Hanegem, Nehalennia, Vulliemoz, Nicolas, Vermeulen, Nathalie“…A.B. reports grants from FEMaLE executive board member and European Commission Horizon 2020 grant; consulting fees from Ethicon Endo Surgery, Medtronic; honoraria for lectures from Ethicon; and support for meeting attendance from Gedeon Richter; A.H. reports grants from MRC, NIHR, CSO, Roche Diagnostics, Astra Zeneca, Ferring; Consulting fees from Roche Diagnostics, Nordic Pharma, Chugai and Benevolent Al Bio Limited all paid to the institution; a pending patent on Serum endometriosis biomarker; he is also Chair of TSC for STOP-OHSS and CERM trials. O.H. reports consulting fees and speaker’s fees from Gedeon Richter and Bayer AG; support for attending meetings from Gedeon-Richter, and leadership roles at the Finnish Society for Obstetrics and Gynecology and the Nordic federation of the societies of obstetrics and gynecology. …”
Publicado 2022
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345077por Piechota, Sabrina, Marchante, Maria, Giovannini, Alexa, Paulsen, Bruna, Potts, Kathryn S, Rockwell, Graham, Aschenberger, Caroline, Noblett, Alexander D, Figueroa, Alexandra B, Sanchez, Marta, Barrachina, Ferran, Wiemer, Klaus, Guzman, Luis, Belchin, Pedro, Pierson Smela, Merrick, Fortuna, Patrick R J, Chatterjee, Pranam, Tran, Nam D, Kelk, Dawn A, Forti, Marcy, Marcinyshyn, Shelby, Smith, Trozalla, McCulloh, David H, Fernandez-Gonzalez, Marta-Julia, Abittan, Baruch, Ortiz, Silvia, Klein, Joshua U, Klatsky, Peter, Ordonez-Perez, Daniel, Kramme, Christian C“…LIMITATIONS, REASONS FOR CAUTION: While the findings of this study are compelling, the cohort size remains limited and was powered on preliminary pilot studies, and the basic research nature of the study limits generalizability compared to randomized control trials. Additionally, use of hCG-triggered cycles results in a heterogenous oocyte cohort, and potential differences in the underlying maturation state of oocytes pre-IVM may limit or bias findings. …”
Publicado 2023
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345078“…The review summarizes evidence from nineteen high‐quality studies, including 13 randomized controlled trials and six quasi‐experimental studies. This review includes studies that evaluated the effects of police‐led diversionary practices compared to traditional processing for youth under 18 years of age. …”
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345079por Mack, Andrew R, Bethel, Christopher, Marshall, Steven, Patel, Robin, Patel, Robin, van Duin, David, Fowler, Vance G, Rhoads, Daniel D, Jacobs, Michael, van den Akker, Focco, Six, David A, Moeck, Greg, Papp-Wallace, Krisztina M, Bonomo, Robert A“…Taniborbactam is currently undergoing phase 3 clinical trials in combination with cefepime (FEP; Fig 1) as part of the β-lactam-BLI (BL-BLI) combination FEP-taniborbactam (FTB). …”
Publicado 2021
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345080por Bagacean, Cristina, Letestu, Rémi, Al Nawakil, Chadi, Brichler, Ségolène, Lévy, Vincent, Sritharan, Nanthara, Delmer, Alain, Dartigeas, Caroline, Leblond, Véronique, Roos-Weil, Damien, Béné, Marie C, Clavert, Aline, Chaoui, Driss, Genet, Philippe, Guieze, Romain, Laribi, Kamel, Touileb, Yamina, Drenou, Bernard, Willems, Lise, Tomowiak, Cécile, Merabet, Fatiha, Puppink, Christian, Legendre, Hugo, Troussard, Xavier, Malartre, Stéphanie, Cymbalista, Florence, Michallet, Anne-Sophie“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an ongoing global pandemic. Phase III trials have demonstrated excellent efficacies of mRNA vaccines against SARS-CoV-2 in large population studies (Baden LR, NEJM, 2021; Polack FP, NEJM, 2020). …”
Publicado 2021
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