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1261por Gehan, E A“…This is a review paper which gives a discussion of various aspects of clinical trials in cancer research. Since the conduct of the first randomized controlled clinical trial in cancer patients in the mid-1950's, substantial progress has been made in the utilization of the clinical trial technique for the evaluation of therapeutic efficiacy. …”
Publicado 1979
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1265“…Elactocin is a novel anti-tumour antibiotic which has potent activity in vitro against a range of tumours. This phase I trial of elactocin identified the dose-limiting toxicity as profound anorexia and malaise. …”
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1269por Fairhall, Nicola, Aggar, Christina, Kurrle, Susan E, Sherrington, Catherine, Lord, Stephen, Lockwood, Keri, Monaghan, Noeline, Cameron, Ian D“…METHODS AND DESIGN: A single centre randomised controlled trial comparing a multidisciplinary intervention with usual care. …”
Publicado 2008
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1270por Murray, Elizabeth, Khadjesari, Zarnie, White, Ian R, Kalaitzaki, Eleftheria, Godfrey, Christine, McCambridge, Jim, Thompson, Simon G, Wallace, Paul“…There is a strong argument that interventions delivered online should also be evaluated online to maximize the trial’s external validity. Conducting a trial online can help reduce research costs and improve some aspects of internal validity. …”
Publicado 2009
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1271“…Do results of clinical trials apply consistently and equally across all clinically meaningful subclasses of patients enrolled in the studies? …”
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1273“…BACKGROUND: Lack of transparency in clinical trial conduct, publication bias and selective reporting bias are still important problems in medical research. …”
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1274por Bowalekar, Suresh“…As a consequence to this, the US Food and Drug Administration released a critical path initiative document in 2004, highlighting the need for developing innovative trial designs. One of the innovations suggested the use of adaptive designs for clinical trials. …”
Publicado 2011
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1275“…BACKGROUND: We aimed to make individual patient data from the International Stroke Trial (IST), one of the largest randomised trials ever conducted in acute stroke, available for public use, to facilitate the planning of future trials and to permit additional secondary analyses. …”
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1276por Babre, Deven“…Data generated in all clinical trial are recorded on the data collection instrument Case report Form / Electronic Case Report Form by investigators located at various sites in various countries. …”
Publicado 2010
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1277por Agarwal, Pankaj K.Enlace del recurso
Publicado 2011
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1278por Tepper, Joel E.“…The author discusses the role of clinical trials in clinical medicine.…”
Publicado 2010
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1279“…This article reviews the current and future directions of clinical research with respect to genomic sequencing, a technology that is just beginning to find its way into clinical trials both nationally and worldwide. We highlight the currently available types of genomic sequencing platforms, outline the advantages and disadvantages of each, and compare first- and next-generation techniques with respect to capabilities, quality, and cost. …”
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