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  1. 1421
    “…Secondary outcomes will include cost-effectiveness, patient satisfaction and complications data. TRIAL REGISTRATION: Current Controlled Trials ISRCTN03013488; ClinicalTrials.gov Identifier: NCT01352247…”
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    Total or Partial Knee Arthroplasty Trial - TOPKAT: study protocol for a randomised controlled trial
  2. 1422
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    OSAKA Trial: A Randomized, Controlled Trial Comparing Tacrolimus QD and BD in Kidney Transplantation
  3. 1423
    “…The purpose of the current trial (referred to as the REmediation of SPatial Neglect or RESPONSE trial) is to compare TAPAT to an active control training condition, include a larger sample of patients, and assess both cognitive and functional outcomes. …”
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    Randomized control trial of computer-based rehabilitation of spatial neglect syndrome: the RESPONSE trial protocol
  4. 1424
    “…PURPOSE: The Central Retinal Enrichment Supplementation Trials (CREST) aim to investigate the potential impact of macular pigment (MP) enrichment, following supplementation with a formulation containing 10 mg lutein (L), 2 mg zeaxanthin (Z) and 10 mg meso-zeaxanthin (MZ), on visual function in normal subjects (Trial 1) and in subjects with early age-related macular degeneration (AMD; Trial 2). …”
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    Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials
  5. 1425
    Publicado 2014
    “…This paper describes the protocol for SPIRIT (Supporting Policy In health with Research: an Intervention Trial), a trial designed to test the effectiveness of a multifaceted programme to build organisational capacity for the use of research evidence in policy and programme development. …”
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    Supporting Policy In health with Research: an Intervention Trial (SPIRIT)—protocol for a stepped wedge trial
  6. 1426
    “…BACKGROUND: Randomized controlled trials play a central role in evidence-based practice, but recruitment of participants, and retention of them once in the trial, is challenging. …”
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    Systematic techniques for assisting recruitment to trials (START): study protocol for embedded, randomized controlled trials
  7. 1427
    “…BACKGROUND: The ‘Adaptive Designs Accelerating Promising Trials into Treatments (ADAPT-IT)’ project is a collaborative effort supported by the National Institutes of Health (NIH) and United States Food & Drug Administration (FDA) to explore how adaptive clinical trial design might improve the evaluation of drugs and medical devices. …”
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    The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial: an adaptive trial design case study
  8. 1428
    “…The Sustained Aeration of Infant Lungs (SAIL) trial was designed to study this question. METHODS/DESIGN: This multisite prospective randomized controlled unblinded trial will recruit 600 infants of 23 to 26 weeks gestational age who require respiratory support at birth. …”
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    Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial
  9. 1429
    “…The objective of the Cyclical Lower Extremity Exercise (CYCLE) trial for Parkinson’s disease is to determine the effects of forced exercise cycling on motor and non-motor performance when compared to voluntary rate cycling and a non-exercise control group. …”
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    The cyclical lower extremity exercise for Parkinson’s trial (CYCLE): methodology for a randomized controlled trial
  10. 1430
    “…Trial Forge (www.trialforge.org) is an initiative that aims to increase the evidence base for trial decision making and, in doing so, to improve trial efficiency. …”
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    Making randomised trials more efficient: report of the first meeting to discuss the Trial Forge platform
  11. 1431
    “…The PACE trial was a four-arm trial of specialist medical care, compared with specialist medical care with a supplementary therapy: adaptive pacing therapy, cognitive–behavioural therapy or graded exercise therapy, for patients with chronic fatigue syndrome. …”
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    The planning, implementation and publication of a complex intervention trial for chronic fatigue syndrome: the PACE trial
  12. 1432
    “…OBJECTIVE: The SELF Trial examined the effect of adding individual, self-efficacy (SE) enhancement sessions to standard behavioral weight loss treatment (SBT). …”
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    The SELF Trial: A self-efficacy based behavioral intervention trial for weight-loss maintenance
  13. 1433
    “…The mainstay of treatment is with graduated compression bandaging; however, treatment is often prolonged and up to one quarter of venous leg ulcers do not heal despite standard care. Two previous trials have suggested that low-dose aspirin, as an adjunct to standard care, may hasten healing, but these trials were small and of poor quality. …”
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    Aspirin for Venous Ulcers: Randomised Trial (AVURT): study protocol for a randomised controlled trial
  14. 1434
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    Reporting remit and function of trial steering committees in randomised controlled trials: review of published literature
  15. 1435
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    What are the main inefficiencies in trial conduct? A survey of staff at registered clinical trials units
  16. 1436
    “…In a final study of visually-evoked Local Field Potentials in partially anesthetized ferrets, the methodology is able to reveal recurrence structures of neural responses with trial-to-trial variability. Focusing on different frequency bands, the δ-band activity is much less recurrent than α-band activity. …”
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    Statistical Frequency-Dependent Analysis of Trial-to-Trial Variability in Single Time Series by Recurrence Plots
  17. 1437
    “…METHODS/DESIGN: This study is an ongoing randomized trial in Jakarta, Indonesia, that began in July 2012. …”
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    BReastfeeding Attitude and Volume Optimization (BRAVO) trial: study protocol for a randomized controlled trial
  18. 1438
    “…These introspection-based data revealed that, as found in previous research, urges to err were strongest for incongruent trials. Our findings reveal, first, that subjects can successfully perform this new task, even though it is more complex than that of previous studies, and second, that, in this new paradigm, reliable subjective, metacognitive data can be obtained on a trial-by-trial basis. …”
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    Metacognition of Working Memory Performance: Trial-by-Trial Subjective Effects from a New Paradigm
  19. 1439
    “…The trial will be conducted across five sites in the United Kingdom. …”
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    Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial
  20. 1440
    “…However, with a prolonged duration from recruitment to publication, high-cost trial implementation, and a rigid trial protocol, RCTs are perceived as an impractical evaluation methodology for most mHealth apps. …”
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    Beyond the Randomized Controlled Trial: A Review of Alternatives in mHealth Clinical Trial Methods
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