“…BACKGROUND: Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant results and whether the proportion of trials with significant results differs when no treatment effect estimate or p-value is posted. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Patient and public involvement in research (PPIR) may improve trial recruitment rates, but it is unclear how. Where trials use PPIR to improve design and conduct, many do not communicate this clearly to potential participants. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Conducting clinical trials to assess experimental treatments for potentially pandemic infectious diseases is challenging. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Statin Induced Regression of Cardiomyopathy Trial (SIRCAT) was a randomized, placebo-controlled study. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Materias: “…Clinical Trial Protocol…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT02650609. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, administration of Bifidobacterium breve strain BBG-001 to preterm infants did not affect NEC incidence in a multicenter randomised controlled phase 3 trial (PiPS trial). Using a subset of these subjects we compared the fecal microbiome of probiotic and placebo groups and assessed the impact of early antibiotic treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This editorial provides a brief overview of the importance of pilot or feasibility trials or studies, the challenges with current practices in their conduct and reporting, an introduction to the Consolidated Standards of Reporting Trials (CONSORT) extension to pilot trials aimed at improving their reporting, along with some key resources on aspects related to pilot and feasibility studies.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Platform (ICTRP) as of December 2017 regarding their frequency, design, type of ginseng, dosage, duration, condition, funding sources, and publication status. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PURPOSE: To analyze and compare the clinical registration information about acupuncture and moxibustion for intervention characteristics. METHODS: Clinical trials from the International Clinical Trials Registry Platform of the World Health Organization in acupuncture and moxibustion were comprehensively collected from 2013 to 2015; data were independently screened and extracted by two retrievers, and relevant data involving either basic descriptions or intervention characteristics were analyzed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Randomised controlled clinical trials typically have a relatively brief in-trial follow-up period which can underestimate safety signals and fail to detect long-term hazards, which may take years to appear. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Adrian Grant pioneered methodological innovations in the randomised trials organised by the Perinatal Trials Service established at the national Perinatal Epidemiology Unit in Oxford, UK. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This approach has the potential to obtain conclusive results earlier than with new standalone trials or conventional, pairwise meta-analyses. METHODS: Network meta-analyses can also be used to plan future trials. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is often unclear what specific adaptive trial design features lead to an efficient design which is also feasible to implement. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Registration of interventional trials of Food and Drug Administration–regulated drug and biological products and devices became a legal requirement in 2007; the vast majority of these trials are registered in ClinicalTrials.gov. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso