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  1. 141
    “…BACKGROUND: Very little is known about the proportion of oncology trials that get published, the time it takes to publish them, or the reasons why oncology trials do not get published. …”
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    Time to publication of oncology trials and why some trials are never published
  2. 142
    “…BACKGROUND: There is an increasing demand by non-commercial funders that trialists should provide access to trial data once the primary analysis is completed. …”
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    Data sharing in clinical trials – practical guidance on anonymising trial datasets
  3. 143
    “…Less well understood are trial-by-trial interactions, whereby the multisensory composition of stimuli experienced during previous trials shapes performance during a subsequent trial. …”
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    Trial by trial dependencies in multisensory perception and their correlates in dynamic brain activity
  4. 144
    “…‘Assumptions are made and most assumptions are wrong’ (Albert Einstein) Clinical trial conduct must be consistent with trial design, yet conducting the trial according to plan remains a major challenge. …”
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    Ensuring trial conduct is consistent with trial design: assumption is the enemy of quality
  5. 145
    “…Neural activity fluctuates over time, creating considerable variability across trials. This trial-by-trial neural variability is dramatically reduced (“quenched”) after the presentation of sensory stimuli. …”
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    The Relationship between Trial-by-Trial Variability and Oscillations of Cortical Population Activity
  6. 146
    “…An analysis using a Kalman filter confirmed that people used the prediction error rather than the previous temporal error for trial-by-trial corrections in fast arm movements, saccades and button press.…”
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    Prediction and final temporal errors are used for trial-to-trial motor corrections
  7. 147
    “…INTRODUCTION: Promoting emergency medicine (EM) clinical trials research remains a priority. To characterize the status of clinical EM research, this study assessed trial quality, funding source, and publication of EM clinical trials and compared EM and non-EM trials on these key metrics. …”
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    Quality and Publication of Emergency Medicine Trials Registered in ClinicalTrials.gov
  8. 148
    por Honig, Maija, Ma, Wei Ji, Fougnie, Daryl
    Publicado 2020
    “…Reported memory uncertainty is correlated with memory error, showing that people incorporate their trial-to-trial memory quality into rewarded decisions. …”
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    Humans incorporate trial-to-trial working memory uncertainty into rewarded decisions
  9. 149
    “…Early phase clinical trials are the first step in testing new medications and therapeutics developed by clinical and biomedical investigators. …”
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    Improving the efficiency of clinical trials by standardizing processes for Investigator Initiated Trials
  10. 150
    “…To date, a large number of clinical trials addressing various aspects of COVID19 have been registered in the Chinese Clinical Trial Registry (ChiCTR), including more than 200 interventional studies. …”
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    Profiles of COVID-19 clinical trials in the Chinese Clinical Trial Registry
  11. 151
    “…However, to date, clinical trial reporting for NAFLD has been suboptimal, limiting our understanding. …”
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    Stratification of patients in NASH clinical trials: A pitfall for trial success
  12. 152
    “…This article on clinical trial design incorporates the broad experience of members of the Pulmonary Vascular Research Institute’s (PVRI) Innovative Drug Development Initiative (IDDI) as an open debate platform for academia, the pharmaceutical industry and regulatory experts surrounding the future design of clinical trials in pulmonary hypertension. …”
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    Clinical trial design in phase 2 and 3 trials for pulmonary hypertension
  13. 153
    “…Trial-by-trial texture classification analysis and identifying salient texture related EEG features during active touch that are minimally influenced by movement type and frequency conditions are the main contributions of this work. …”
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    EEG-based trial-by-trial texture classification during active touch
  14. 154
    “…Adopting indices of poor interpretability in clinical trials may lead to trial failure. This study aims to understand the impact of using indices of different interpretability in clinical trials. …”
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    Interpretable Trials: Is Interpretability a Reason Why Clinical Trials Fail?
  15. 155
    “…The onset of the COVID-19 pandemic necessitated several modifications to the trial in order to protect participants from potential exposure to infection. …”
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    Trials and Tribulations: mHealth Clinical Trials in the COVID-19 Pandemic
  16. 156
    “…BACKGROUND: We aim to analyze the characteristics of stereotactic radiotherapy trials registered on ClinicalTrials.gov, and to compare completed and stopped early trials to identify predictors of trial failure. …”
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    Characteristics of stereotactic radiotherapy clinical trials registered on ClinicalTrials.gov
  17. 157
    “…We were able to reconstruct trial-by-trial biases in participants’ duration reports, which reflect subjective experience of duration, purely from salient events in their visual cortex BOLD activity. …”
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    Trial-by-trial predictions of subjective time from human brain activity
  18. 158
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    De‐risking Clinical Trials: The BIAL Phase I Trial in Foresight
  19. 159
    “…BACKGROUND AND OBJECTIVE: Waste in clinical trials remains rife. We developed an economic model to predict the cost of trials based on input costs, duration, power, number of sites, recruitment eligibility and consenting rates. …”
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    An Economic Model for Estimating Trial Costs with an Application to Placebo Surgery Trials
  20. 160
    por Fleminger, Jessica, Goldacre, Ben
    Publicado 2018
    “…OBJECTIVE: Trial registries are a key source of information for clinicians and researchers. …”
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    Prevalence of clinical trial status discrepancies: A cross-sectional study of 10,492 trials registered on both ClinicalTrials.gov and the European Union Clinical Trials Register
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