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  1. 1581
    “…METHODS/DESIGN: This study is a pragmatic randomized controlled trial. Over 4 successive winters we will recruit 750 healthy children 1–5 years of age. …”
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    DO IT Trial: vitamin D Outcomes and Interventions in Toddlers – a TARGet Kids! randomized controlled trial
  2. 1582
    “…BACKGROUND: Recruiting to randomized controlled trials is fraught with challenges; with less than one third recruiting to their original target. …”
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    Exploring recruitment barriers and facilitators in early cancer detection trials: the use of pre-trial focus groups
  3. 1583
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    Can we recruit to expertise trials? Experience from the total or partial knee arthroplasty trial (TOPKAT)
  4. 1584
    por Rapport, Frances, Clement, Clare
    Publicado 2013
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    Qualitative research within trials: developing a standard operating procedure for a clinical trials unit
  5. 1585
    “…BACKGROUND: Some level of monitoring is usually required during a clinical trial to protect the rights and safety of trial participants and to safeguard the quality and reliability of trial results. …”
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    Risk-proportionate clinical trial monitoring: an example approach from a non-commercial trials unit
  6. 1586
    “…BACKGROUND: We propose a mathematical model for multichannel assessment of the trial-to-trial variability of auditory evoked brain responses in magnetoencephalography (MEG). …”
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    Maximum-likelihood estimation of channel-dependent trial-to-trial variability of auditory evoked brain responses in MEG
  7. 1587
    “…Due to discontinuing glucocorticoids without tapering after seven days, we limit duration of glucocorticoid exposition, which may reduce possible side effects. TRIAL REGISTRATION: 7 September 2009 on ClinicalTrials.gov: NCT00973154.…”
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    Corticosteroid treatment for community-acquired pneumonia - the STEP trial: study protocol for a randomized controlled trial
  8. 1588
    “…OBJECTIVE: To evaluate the utility of the ClinicalTrials.gov registry as a data source for semi-automated trial eligibility screening. …”
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    ClinicalTrials.gov as a Data Source for Semi-Automated Point-Of-Care Trial Eligibility Screening
  9. 1589
    “…The pragmatic study design means that results will give a realistic estimate of the success of the intervention if it were to be rolled out as part of standard smoking cessation service practice. TRIAL REGISTRATION: Current Controlled Trials ISRCTN33031001. …”
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    Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial
  10. 1590
    “…DISCUSSION: This cluster-randomized behavioral intervention study will provide valuable insights on the outcomes and feasibility of employing a T2T treatment approach in clinical practice in the United States. TRIAL REGISTRATION: NCT01407419 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2474-15-389) contains supplementary material, which is available to authorized users.…”
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    The rheumatoid arthritis treat-to-target trial: a cluster randomized trial within the Corrona rheumatology network
  11. 1591
    “…An appropriately equipped and staffed Phase I unit is critical for smooth conduct of a first-in-man clinical trial. The first-in-man prophylactic vaccine trial(s) requires basic infrastructure of clinical trial site, experienced and dedicated site staff and healthy adults as volunteers. …”
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    Phase I (first-in-man) prophylactic vaccine's clinical trials: Selecting a clinical trial site
  12. 1592
    “…Objectives (1) To develop an automated eligibility screening (ES) approach for clinical trials in an urban tertiary care pediatric emergency department (ED); (2) to assess the effectiveness of natural language processing (NLP), information extraction (IE), and machine learning (ML) techniques on real-world clinical data and trials. …”
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    Automated clinical trial eligibility prescreening: increasing the efficiency of patient identification for clinical trials in the emergency department
  13. 1593
    “…The purpose of the current trial (referred to as the TReatment of Social cognition in Schizophrenia Trial or TRuSST) is to compare SocialVille to an active control training condition, include a larger sample of patients, and assess both social cognitive functioning, and functional outcomes. …”
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    Randomized controlled trial of computer-based treatment of social cognition in schizophrenia: the TRuSST trial protocol
  14. 1594
    “…Demonstration of significant reductions in mortality and coagulopathic/inflammatory-related morbidities as a result of pre-hospital plasma administration would be of considerable clinical importance for the management of haemorrhagic shock in both civilian and military populations. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02303964 on 28 November 2014…”
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    Prehospital use of plasma in traumatic hemorrhage (The PUPTH Trial): study protocol for a randomised controlled trial
  15. 1595
    “…Randomized controlled trials (RCTs) are conducted under idealized and rigorously controlled conditions that may compromise their external validity. …”
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    A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results
  16. 1596
    “…BACKGROUND: Confidence that randomized controlled trial (RCT) results accurately reflect intervention effectiveness depends on proper trial conduct and the accuracy and completeness of published trial reports. …”
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    Transparency of Outcome Reporting and Trial Registration of Randomized Controlled Trials Published in the Journal of Consulting and Clinical Psychology
  17. 1597
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    Overcoming a trial ‘adverse event’: impact and experiences of a temporary suspension of randomisation in clinical trials
  18. 1598
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    Enhancing public involvement in trial oversight committees through qualitative research with eight trials facing challenges
  19. 1599
    “…BACKGROUND: Recruitment to trials evaluating the effectiveness of childhood obesity management interventions is challenging. …”
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    Evaluation of recruitment methods for a trial targeting childhood obesity: Families for Health randomised controlled trial
  20. 1600
    Publicado 2014
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    The OSAKA Trial: A Randomized, Controlled Trial Comparing Tacrolimus QD and BD in Kidney Transplantation: Erratum
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