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  1. 1601
    “…Refining immune endpoints to better inform clinical trial design represents a high priority challenge. …”
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    Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials
  2. 1602
    “…TRIAL REGISTRATION: Current Controlled Trials ISRCTN17544090 registered on 23 July 2015. …”
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    Online Artículo Texto
    Morita therapy for depression and anxiety (Morita Trial): study protocol for a pilot randomised controlled trial
  3. 1603
    “…If the pilot is successful, three additional sites will be opened to recruitment, and a further 302 participants recruited across the six main trial sites. Further trial sites may be opened, as necessary. …”
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    TOPPITS: Trial Of Proton Pump Inhibitors in Throat Symptoms. Study protocol for a randomised controlled trial
  4. 1604
    por Goldacre, Ben, Gray, Jonathan
    Publicado 2016
    “…OpenTrials is a collaborative and open database for all available structured data and documents on all clinical trials, threaded together by individual trial. …”
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    Online Artículo Texto
    OpenTrials: towards a collaborative open database of all available information on all clinical trials
  5. 1605
    “…Therefore, we compare the performance of development plans consisting of single‐arm trials followed by randomised two‐arm trials with stand‐alone single‐stage or group sequential randomised two‐arm trials. …”
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    Do single‐arm trials have a role in drug development plans incorporating randomised trials?
  6. 1606
    “…DESIGN/METHODS: Databases were searched using a broad search strategy to identify relevant randomized and quasi-randomized controlled trials. Critical outcomes were pain, fear, distress (when applicable), and use of pain management interventions. …”
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    Process Interventions for Vaccine Injections: Systematic Review of Randomized Controlled Trials and Quasi-Randomized Controlled Trials
  7. 1607
    “…These results indicate that supervised exercise training might be beneficial as a part of standard pregnancy care for overweight/obese women. TRIAL REGISTRATION: ClinicalTrials.gov NCT01243554…”
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    Exercise Training and Weight Gain in Obese Pregnant Women: A Randomized Controlled Trial (ETIP Trial)
  8. 1608
    “…BACKGROUND: Whether information from clinical trial registries (CTRs) and published randomised controlled trial (RCTs) differs remains unknown. …”
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    Major discrepancies between what clinical trial registries record and paediatric randomised controlled trials publish
  9. 1609
    “…This will inform clinical practice and policy for the treatment of gonorrhoea when current therapy with cephalosporins is no longer effective, or is contraindicated. TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number – ISRCTN51783227, Registered on 18 September 2014. …”
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    Gentamicin versus ceftriaxone for the treatment of gonorrhoea (G-TOG trial): study protocol for a randomised trial
  10. 1610
    “…Prolonged follow-up of trial participants after the end of the scheduled trial period can provide important information on both efficacy and safety outcomes. …”
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    Post-trial follow-up methodology in large randomized controlled trials: a systematic review protocol
  11. 1611
    “…RESULTS: Placebo versus drug RCT (n = 146), either prevention trials (n = 57, 39%) or therapeutic interventions (n = 89, 61%), represent more than a third of neonatal trials registered in the National Institute of Health clinical trial database (USA) since 1999. …”
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    Drug versus placebo randomized controlled trials in neonates: A review of ClinicalTrials.gov registry
  12. 1612
    “…OBJECTIVE: To characterize and quantify barriers towards the publication of academic drug trials. STUDY DESIGN: We identified academic drug trials approved during a 3-year period (2004–2007) by the Danish Medicines Agency. …”
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    Barriers towards the publication of academic drug trials. Follow-up of trials approved by the Danish Medicines Agency
  13. 1613
    “…BACKGROUND: The effect of alternative spontaneous breathing trial (SBT) techniques on extubation success and other clinically important outcomes is uncertain. …”
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    Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis
  14. 1614
    “…TRIAL REGISTRATION: ClinicalTrials.gov, ID: NCT02361944. …”
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    The Risk of Oxygen during Cardiac Surgery (ROCS) trial: study protocol for a randomized clinical trial
  15. 1615
    “…INTRODUCTION: Despite increased visibility of clinical trials through international trial registries, patients often remain uninformed of their existence, especially if they do not have access to adequate information about clinical research, including the language of the information. …”
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    Transparency and public accessibility of clinical trial information in Croatia: how it affects patient participation in clinical trials
  16. 1616
    “…CONCLUSIONS: Recommendations discussed include further research to assess the attributes of routinely recorded data, an assessment of public perceptions and the development of strategies to collaboratively improve access to routinely recorded data for research. TRIAL REGISTRATION: International Standard Randomised Controlled Trials, ISRCTN30294119. …”
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    Using routinely recorded data in the UK to assess outcomes in a randomised controlled trial: The Trials of Access
  17. 1617
    “…TRIAL REGISTRATION: ESCAPE trial – NCT01778335 – at www.clinicaltrials.gov. …”
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    Minimal sufficient balance randomization for sequential randomized controlled trial designs: results from the ESCAPE trial
  18. 1618
    “…Purpose: Awaiting trial prisoners (ATPs) are represented in prisons globally, and may stay for long periods in detention. …”
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    Prolonged incarceration and prisoners’ wellbeing: livid experiences of awaiting trial/pre-trial/remand prisoners in Nigeria
  19. 1619
    “…BACKGROUND: Regulations, study design complexity and amounts of collected and shared data in clinical trials render efficient data handling procedures inevitable. …”
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    Mobile electronic versus paper case report forms in clinical trials: a randomized controlled trial
  20. 1620
    “…BACKGROUND/AIMS: We sought to optimise the design of stepped wedge trials with an equal allocation of clusters to sequences and explored sample size comparisons with alternative trial designs. …”
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    Online Artículo Texto
    The optimal design of stepped wedge trials with equal allocation to sequences and a comparison to other trial designs
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