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Mostrando 141 - 160 Resultados de 2,180 Para Buscar '"The Tudors"', tiempo de consulta: 0.13s Limitar resultados
  1. 141
    “…We use AlphaScreen, a chemiluminescence-based technique, to monitor the interactions of chromodomains (MPP8, HP1β and CHD1), tudor domains (JMJD2A) and plant homeodomains (RAG2) with their cognate trimethyllysine histone partners. …”
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    A homogeneous method for investigation of methylation-dependent protein–protein interactions in epigenetics
  2. 142
    “…53BP1 performs essential functions in DNA double-strand break (DSB) repair and it was recently reported that Tudor interacting repair regulator (TIRR) negatively regulates 53BP1 during DSB repair. …”
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    Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
  3. 143
    “…Importantly, SMA-linked SMN(TUDOR) mutant forms (SMN(ST)) failed to interact with FMR(FM). …”
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    SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members
  4. 144
    “…BACKGROUND: The PWWP domain was first identified as a structural motif of 100–130 amino acids in the WHSC1 protein and predicted to be a protein-protein interaction domain. It belongs to the Tudor domain ‘Royal Family’, which consists of Tudor, chromodomain, MBT and PWWP domains. …”
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    Structural and Histone Binding Ability Characterizations of Human PWWP Domains
  5. 145
    “…Interaction of PfSMN (survival of motor neuron, tudor domain containing protein) or PfTu-TSN (Tudor domain of Tudor Staphylococcal nuclease) with PfSmD1 proteins was found to be methylation dependent. …”
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    Organization of Plasmodium falciparum spliceosomal core complex and role of arginine methylation in its assembly
  6. 146
    “…Selective pressure analysis on piRNA pathway and miRNA/siRNA (microRNA/small interfering RNA) pathway genes between teleosts and mammals showed an accelerated evolution of piRNA pathway genes in the teleost lineages, and positive selection on functional PAZ (Piwi/Ago/Zwille) and Tudor domains involved in the Piwi–piRNA/Tudor interaction, suggesting that the amino acid substitutions are adaptive to their functions in piRNA pathway in the teleost fish species. …”
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    Rapid Evolution of piRNA Pathway in the Teleost Fish: Implication for an Adaptation to Transposon Diversity
  7. 147
    “…TUDOR domain–containing proteins (TDRDs) are chiefly responsible for recognizing methyl-lysine/arginine residue. …”
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    PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis
  8. 148
    “…Primary Siwi‐piRISC production occurs on the outer mitochondrial membrane in an Ago3‐independent manner, where Tudor domain‐containing Papi binds unloaded Siwi via its symmetrical dimethylarginines (sDMAs). …”
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    Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyx mori
  9. 149
    “…To promote generation of new piRNA, Krimper uses its two Tudor domains to bind Aub and Ago3 in opposite modification and piRNA-loading states. …”
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    Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
  10. 150
    “…Mutations targeting the aromatic cage of the Np95 tandem Tudor domain (Y188A and Y191A) abolished specific H3 histone tail binding. …”
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    The multi-domain protein Np95 connects DNA methylation and histone modification
  11. 151
    “…How ubiquitin recruits 53BP1 to break sites remains enigmatic since its relocalization involves recognition of H4 Lys20 (H4K20) methylation by its Tudor domain. Here we elucidate how 53BP1 is recruited to the chromatin that flanks DSB sites. …”
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    53BP1 is a reader of the DNA damage-induced H2A Lys15 ubiquitin mark
  12. 152
    “…We also show that the C-terminal region, containing the Tudor domains of KDM4C, is essential for its association with mitotic chromatin. …”
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    KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
  13. 153
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    The immunoglobulin CH1 constant region modulates antigen binding affinity and functional activities of the broadly neutralizing 2F5 HIV specific antibody
  14. 154
    “…We describe the application of the protocol on the structurally analogous Tudor domains with disparate functionalities as a model system. …”
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    Characterization of backbone dynamics using solution NMR spectroscopy to discern the functional plasticity of structurally analogous proteins
  15. 155
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    P11-20. HIV-1 gp41-specific mucosal IgAs from highly exposed but IgG seronegative women block HIV-1 epithelial transcytosis and neutralize CD4+ cell infection
  16. 156
    “…This effect was mainly observed in experiments performed using the Tudor domains that may interact with histone deacetylase class 1 (HDAC) and this interaction probably reduces the mediated activation of PPARγ. …”
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    Regulation of adipogenesis by nuclear receptor PPARγ is modulated by the histone demethylase JMJD2C
  17. 157
    “…Here, we show that SMA patient-derived missense mutations in the Drosophila SMN Tudor domain exhibit a pronounced temperature sensitivity that affects organismal viability, larval locomotor function and adult longevity. …”
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    Temperature-sensitive spinal muscular atrophy-causing point mutations lead to SMN instability, locomotor defects and premature lethality in Drosophila
  18. 158
    “…TDRD3 directly interacts with DHX9 via its Tudor domain. This interaction is important for recruiting DHX9 to target gene promoters, where it resolves R-loops in a helicase activity-dependent manner to facilitate gene expression. …”
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    TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution
  19. 159
    “…Drosophila females heterozygous for the tudor[1] mutation produce normal offspring, while their homozygous sisters produce offspring that lack a germ line. …”
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    Identifying sexual differentiation genes that affect Drosophila life span
  20. 160
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    Evaluation of gastric acid in dependence of pre-operative fasting
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