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9201por Bolton, Kristy A., Whelan, Jillian, Fraser, Penny, Bell, Colin, Allender, Steven, Brown, Andrew D.“…These research projects utilised systems science and implementation science to co-create childhood obesity prevention interventions. The team undertaking this translation comprised research academics, implementation specialists and practitioners, practice-based researchers and a systems dynamicist. …”
Publicado 2022
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9202“…Establishing accurate serological markers of protection against IGbsD could enable use of efficient clinical trial designs for vaccine development and licensure, without needing to undertake efficacy trials in prohibitively large number of mother-infant dyads. …”
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9203por Vallejo-Torres, Laura, García-Lorenzo, Borja, Edney, Laura Catherine, Stadhouders, Niek, Edoka, Ijeoma, Castilla-Rodríguez, Iván, García-Pérez, Lidia, Linertová, Renata, Valcárcel-Nazco, Cristina, Karnon, Jonathan“…Analysis of the use of HOC-based CETs by researchers undertaking CEAs in countries with different decision-making contexts will provide valuable insights to further understand barriers and facilitators to the acceptance and use of HOC-based CETs. …”
Publicado 2021
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9204por Fisher, Harriet, Chantler, Tracey, Finn, Adam, Kesten, Joanna, Hickman, Matthew, Letley, Louise, Mounier-Jack, Sandra, Thomas, Clare, Worthington, Katie, Yates, Julie, Audrey, Suzanne“…METHODS: We used co-production research methodologies and the ‘person-based approach’ involving the following iterative stages: (i) collating and analysing primary and secondary evidence, including HPV vaccine communication materials, interviews and workshops; (ii) developing guiding principles; (iii) undertaking a behavioural analysis informed by the Behaviour Change Wheel and the Behaviour Change Technique taxonomy; (iv) development of a preliminary logic model; (v) co-production of resources, and; (vi) refinement of resources informed by feedback from young people and key informants. …”
Publicado 2022
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9205por Fleming, Jonathon, Marvel, Skylar W., Supak, Stacy, Motsinger-Reif, Alison A., Reif, David M.“…BACKGROUND: Presenting a comprehensive picture of geographic data comprising multiple factors is an inherently integrative undertaking. Visualizing such data in an interactive form is essential for public sharing and geographic information systems (GIS) analysis. …”
Publicado 2022
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9206“…Participants were 144 physiotherapy students, cluster randomized by tutorial groups (exp n = 70, con n = 74), undertaking their neurological curricula. The experimental group was exposed to MASK-ED™ simulation in five out of a potential thirty-two tutorials (16%) whilst the control continued with role-play with peers. …”
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9207por Bhaludin, Basrull N., Tunariu, Nina, Senthivel, Nishanthi, Babiker, Amna, Soneji, Neil D., Hujairi, Nabil, Sharma, Bhupinder, McGrath, Sophie E., Okines, Alicia F., Ring, Alistair E., Messiou, Christina, Downey, Kate, Koh, Dow-Mu“…The clinical indications for undertaking the WBMRI examinations were recorded. Data on the extent and distribution of the disease were collected and discordance/concordance of disease status across the imaging modalities were compared. …”
Publicado 2022
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9208por De la Ruelle, Lobke P., de Zoete, Annemarie, de Boer, Michiel R., van Tulder, Maurits W., Ostelo, Raymond, Rubinstein, Sidney M.“…The respondents indicated which intervention(s) they would recommend or undertake. Based upon these vignettes, we were able to determine whether their management approach adhered to clinical guidelines. …”
Publicado 2022
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9209“…This pilot study assessed the feasibility and acceptability of undertaking a four-week home-based resistance ‘exercise snacking’ intervention (performed either once, twice, or thrice daily) when delivered and monitored remotely in older adults. …”
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9210por Bruce Metadata, Pepa, Ainscough, Kate, Hatter, Lee, Braithwaite, Irene, Berry, Lindsay R., Fitzgerald, Mark, Hills, Thomas, Brickell, Kathy, Cosgrave, David, Semprini, Alex, Morpeth, Susan, Berry, Scott, Doran, Peter, Young, Paul, Beasley, Richard, Nichol, Alistair“…METHODS: We initially planned to undertake a multicentre, phase III, parallel-group, open-label RCT, to determine if hydroxychloroquine (HCQ) taken once a week was effective in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in healthcare workers (HCW) aged ≥ 18 years in New Zealand (NZ) and Ireland. …”
Publicado 2022
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9211por Naef, Rahel, Filipovic, Miodrag, Jeitziner, Marie-Madlen, von Felten, Stefanie, Safford, Judith, Riguzzi, Marco, Rufer, Michael“…METHODS: To test the clinical effectiveness and explore the implementation of a multicomponent, nurse-led family support intervention in ICUs, we will undertake a parallel, cluster-randomized, controlled, multicenter superiority hybrid-type 1 trial. …”
Publicado 2022
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9212por Sykes, Michael, O’Halloran, Elaine, Mahon, Lucy, McSharry, Jenny, Allan, Louise, Thomson, Richard, Finch, Tracy, Kolehmainen, Niina“…The QIC aims to support national audit recipients to undertake improvement actions tailored to their local context. …”
Publicado 2022
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9213por Rudman, Najda, Kifer, Domagoj, Kaur, Simranjeet, Simunović, Vesna, Cvetko, Ana, Pociot, Flemming, Morahan, Grant, Gornik, Olga“…AIMS/HYPOTHESIS: Individual variation in plasma N-glycosylation has mainly been studied in the context of diabetes complications, and its role in type 1 diabetes onset is largely unknown. Our aims were to undertake a detailed characterisation of the plasma and IgG N-glycomes in patients with recent onset type 1 diabetes, and to evaluate their discriminative potential in risk assessment. …”
Publicado 2022
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9214por Chirwa, Gowokani Chijere“…The magnitude was lower in rural areas (0.075; %95CI = 0.059, 0.090; p < 0.01) than in urban areas (0.195; %95CI = 0.162, 0.228 p < 0.001). After undertaking a decomposition of the concentration index, we found that age, education, rural or urban location, and wealth status account for more than 95% of the socioeconomic inequality in cervical cancer uptake. …”
Publicado 2022
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9215por Greenwood, Sharlene A., Beckley-Hoelscher, Nicholas, Asgari, Elham, Ayis, Salma, Baker, Luke A., Banerjee, Debasish, Bhandari, Sunil, Bramham, Kate, Chilcot, Joseph, Burton, James, Kalra, Philip A., Lightfoot, Courtney J., McCafferty, Kieran, Mercer, Thomas H., Okonko, Darlington O., Oliveira, Benjamin, Reid, Chante, Smith, Alice C., Swift, Pauline A., Mangelis, Anastasios, Watson, Emma, Wheeler, David C., Wilkinson, Thomas J., Reid, Fiona, Macdougall, Iain C.“…An additional exercise training programme for patients in both groups was initiated and completed between 4 and 12 weeks, to determine the effect of iron repletion compared to placebo treatment in the context of patients undertaking an exercise programme. Additional secondary outcomes include fatigue, physical function, muscle strength, muscle metabolism, quality of life, resting blood pressure, clinical chemistry, safety and harms associated with the iron therapy intervention and the exercise training intervention, and hospitalisations. …”
Publicado 2022
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9216por Gates, Michelle, Gates, Allison, Pieper, Dawid, Fernandes, Ricardo M, Tricco, Andrea C, Moher, David, Brennan, Sue E, Li, Tianjing, Pollock, Michelle, Lunny, Carole, Sepúlveda, Dino, McKenzie, Joanne E, Scott, Shannon D, Robinson, Karen A, Matthias, Katja, Bougioukas, Konstantinos I, Fusar-Poli, Paolo, Whiting, Penny, Moss, Stephana J, Hartling, Lisa“…INTERVENTION: Four stage process established by the EQUATOR Network for developing reporting guidelines in health research: project launch (establish a core team and expert advisory group, register intent), evidence reviews (systematic review of published overviews to describe reporting quality, scoping review of methodological guidance and author reported challenges related to undertaking overviews of reviews), modified Delphi exercise (two online Delphi surveys to reach agreement (≥70%) on relevant reporting items followed by a virtual face-to-face meeting), and development of the reporting guideline. …”
Publicado 2022
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9217por Self, Alice, Chen, Qingchao, Desiraju, Bapu Koundinya, Dhariwal, Sumeet, Gleed, Alexander D, Mishra, Divyanshu, Thiruvengadam, Ramachandran, Chandramohan, Varun, Craik, Rachel, Wilden, Elizabeth, Khurana, Ashok, Bhatnagar, Shinjini, Papageorghiou, Aris T, Noble, J Alison“…OBJECTIVE: The aim of this study is to improve pregnancy and risk assessment for women in underserved regions. Therefore, we are undertaking the Computer-Assisted Low-Cost Point-of-Care UltraSound (CALOPUS) project, bringing together experts in machine learning and clinical obstetric ultrasound. …”
Publicado 2022
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9218por Yonel, Z., Kuningas, K., Sharma, P., Dutton, M., Jalal, Z., Cockwell, P., Webber, J., Narendran, P., Dietrich, T., Chapple, I. L. C.“…Allied health care professionals (AHPs) are skilled in undertaking risk assessment and delivering preventative advice, providing opportunities to access large proportions of the population who may not visit their doctor, within non-traditional community settings. …”
Publicado 2022
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9219por Bolton, C, Smith, C G, McNeece, A, Sultan, S, Alexiou, V, Hackland, A, Crook, J, Nguyen, H D, Champions, Cluster, Thyagarajan, M, Shiekh, Z, Cotter, C, Nisa, P Reis, Al-Abadi, E, Chippington, S, Compeyrot-Lacassagne, S, Filer, A, Wedderburn, L, Croft, Adam“…DESCRIPTION/METHOD: Aims: 1) To describe the protocol for undertaking minimally invasive ultrasound-guided synovial tissue biopsies in children and young people with arthritis, for the purpose of research, alongside routine clinical care. 2) To investigate whether high-quality synovial tissue can be obtained that is suitable for downstream applications including single cell profiling technologies, histology and digital spatial profiling. …”
Publicado 2022
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9220por Mikolaizak, A. Stefanie, Rochester, Lynn, Maetzler, Walter, Sharrack, Basil, Demeyer, Heleen, Mazzà, Claudia, Caulfield, Brian, Garcia-Aymerich, Judith, Vereijken, Beatrix, Arnera, Valdo, Miller, Ram, Piraino, Paolo, Ammour, Nadir, Gordon, Mark Forrest, Troosters, Thierry, Yarnall, Alison J., Alcock, Lisa, Gaßner, Heiko, Winkler, Jürgen, Klucken, Jochen, Schlenstedt, Christian, Watz, Henrik, Kirsten, Anne-Marie, Vogiatzis, Ioannis, Chynkiamis, Nikolaos, Hume, Emily, Megaritis, Dimitrios, Nieuwboer, Alice, Ginis, Pieter, Buckley, Ellen, Brittain, Gavin, Comi, Giancarlo, Leocani, Letizia, Helbostad, Jorunn L., Johnsen, Lars Gunnar, Taraldsen, Kristin, Blain, Hubert, Driss, Valérie, Frei, Anja, Puhan, Milo A., Polhemus, Ashley, Bosch de Basea, Magda, Gimeno, Elena, Hopkinson, Nicholas S., Buttery, Sara C., Hausdorff, Jeffrey M., Mirelman, Anat, Evers, Jordi, Neatrour, Isabel, Singleton, David, Schwickert, Lars, Becker, Clemens, Jansen, Carl-Philipp“…The populations of the Innovative Medicine Initiative-Joint Undertaking represent neurodegenerative conditions (Parkinson’s Disease), respiratory disease (Chronic Obstructive Pulmonary Disease), neuro-inflammatory disorder (Multiple Sclerosis), fall-related injuries, osteoporosis, sarcopenia, and frailty (Proximal Femoral Fracture). …”
Publicado 2022
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