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  1. 9221
    “…Given the relatively shorter-term duration of the clinical trials, estimating the longer-term benefit associated with tolvaptan via extrapolation of the treatment effect is an important undertaking. METHODS: A model was developed to simulate a cohort of patients with ADPKD at risk of rapid progression and predict their long-term outcomes using an algorithm organized around the Mayo Risk Classification system, which has five subclasses (1A through 1E) based on estimated kidney growth rates. …”
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    A disease progression model estimating the benefit of tolvaptan on time to end-stage renal disease for patients with rapidly progressing autosomal dominant polycystic kidney disease
  2. 9222
    “…BACKGROUND: Increased occurrence of mucormycosis during the second wave of COVID-19 pandemic in early 2021 in India prompted us to undertake a multi-site case–control investigation. …”
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    A case control investigation of COVID-19 associated mucormycosis in India
  3. 9223
    “…The aim of this study was to assess the feasibility of undertaking a cluster randomised controlled trial to test an intervention to reduce non-indicated imaging for low back pain in general medical practice. …”
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    Feasibility of testing the effectiveness of a theory-informed intervention to reduce imaging for low back pain: a pilot cluster randomised controlled trial
  4. 9224
    “…Consequently, many Indigenous communities, organizations and governments have been undertaking more cultural and community-based approaches to suicide prevention. …”
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    Centering Indigenous knowledge in suicide prevention: a critical scoping review
  5. 9225
    “…METHODS: This is a prospective mixed methods study incorporating the collection of quantitative data to describe the epidemiology of work related sprains and strains injuries presenting to the regional health centre (Hastings Health Centre) over a period of 24 months and qualitative data from participants presenting at the health centre to identify high risk industry sectors/ occupations/ workplaces and tasks and design, develop and apply prevention through design principles/ solutions/interventions to critical features of the work and work environment and undertake an outcome evaluation during the last 6 months of the project. …”
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    A New Zealand regional work-related sprains and strains surveillance, management and prevention programme: study protocol
  6. 9226
    “…Harmonization and consensus for innovation would be needed across countries because drug development is a global undertaking. This SLR envisages a more holistic approach to evaluation, wherein the value provided to patients and health systems is accounted for. …”
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    Assessing Definitions and Incentives Adopted for Innovation for Pharmaceutical Products in Five High-Income Countries: A Systematic Literature Review
  7. 9227
    “…The primary objectives are to establish the feasibility (i) of delivering the developed intervention in existing care pathways and (ii) of undertaking a randomised controlled trial of the intervention. …”
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    Investigating strategies to improve AccesS to Kidney transplantation (the ASK trial): a protocol for a feasibility randomised controlled trial with parallel process evaluation
  8. 9228
    “…BACKGROUND: Existing guidelines recommend statisticians remain blinded to treatment allocation prior to the final analysis and that any interim analyses should be conducted by a separate team from the one undertaking the final analysis. However, there remains substantial variation in practice between UK Clinical Trials Units (CTUs) when it comes to blinding statisticians. …”
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    Developing guidance for a risk-proportionate approach to blinding statisticians within clinical trials: a mixed methods study
  9. 9229
    “…As with other paediatric clinical trials, researchers undertaking paediatric epilepsy clinical trials face a range of challenges that may compromise external validity MAIN BODY: In this paper, we critically reflect upon the factors which impacted recruitment to the pilot phase of a phase IV unblinded, randomised controlled 3×2 factorial trial examining the effectiveness of two antiseizure medications (ASMs) and a sleep behaviour intervention in children with Rolandic epilepsy. …”
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    The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial
  10. 9230
    “…Identifying the cerebral arterial branches is essential for undertaking a computational approach to cerebrovascular imaging. …”
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    Automated in-depth cerebral arterial labelling using cerebrovascular vasculature reframing and deep neural networks
  11. 9231
    “…BACKGROUND: Maintenance hemodialysis(MHD) patients often suffer from fatigue and are recommended to undertake physical activities. The optimal format of exercise rehabilitation for MHD patients remains uncertain despite demonstrated health benefits. …”
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    Does Intradialytic Group Exercise Programme Influence Patient-Reported Outcomes, Laboratory Parameters, and Anthropometric Parameters in Maintenance Hemodialysis Patients? A Single-Group Repeated-Measures Trial
  12. 9232
    “…FUNDING: The study was funded by the 10.13039/501100010767Innovative Medicines Initiative Joint Undertaking (https://www.imi.europa.eu/) under Grant Agreement No. 115620 (COMBACTE-CARE).…”
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    Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)
  13. 9233
    “…BACKGROUND: The UK National Health Service (NHS) is ideally placed to undertake research. The UK Government recently launched its vision of research within the NHS to improve research culture and activity amongst its staff. …”
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    The research interest, capacity and culture of NHS staff in South East Scotland and changes in attitude to research following the pandemic: a cross-sectional survey
  14. 9234
    por Prof. Felt, Ulrike
    Publicado 2014
    “…What justifies societal engagement with and support for such a cost-intensive long-term scientific undertaking? And finally, in what ways does (and did) this research enterprise contribute to the development of contemporary societies?…”
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    What science for what kind of society? Reflecting the development of big science
  15. 9235
    por Treviño Ronzón, Ernesto
    Publicado 2020
    “…Palti (2018) intends to tell a story of the political, an original and interesting undertaking that he titled “archeology”, largely following the way of thinking inaugurated by Michel Foucault. …”
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    La importancia de hacer historia conceptual de lo político
  16. 9236
    “…ABSTRACT: The reason for undertaking this study was to investigate soft tissue response to high-intensity laser therapy (HILT) by measuring changes in skin surface temperature and longissimus dorsi muscle tone in the thoracolumbar back area in Thoroughbreds with back pain and diagnosed with and without Kissing Spines Syndrome (KSS). …”
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    A Preliminary Study of the Influence of High Intensity Laser Therapy (HILT) on Skin Surface Temperature and Longissimus Dorsi Muscle Tone Changes in Thoroughbred Racehorses with Back Pain
  17. 9237
    “…However, the decision to undertake oesophagectomy is significant as it exposes the patient to a substantial risk of morbidity and mortality. …”
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    Preoperative risk modelling for oesophagectomy: A systematic review
  18. 9238
    “…CONCLUSIONS: Streamlining and automating 2 of the most common and burdensome PHIM undertakings could drastically reduce health care consumers’ PHIM workload: developing and maintaining accurate current and past health summaries and tracking medical bills and insurance claims to reconcile discrepancies. …”
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    A Description of Personal Health Information Management Work With a Spotlight on the Practices of Older Adults: Qualitative e-Delphi Study With Professional Organizers
  19. 9239
    “…PURPOSE: To explore stakeholders' experiences with undertaking first-time implementation of a group, task-oriented CBEP-HCP for people post-stroke and describe associated personnel and travel costs. …”
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    What matters to program partners when implementing a community-based exercise program for people post-stroke? A theory-based qualitative study and cost analysis
  20. 9240
    “…The I‐STEM is a sensitising tool that defines key considerations and activities for undertaking stakeholder engagement activities across an implementation process. …”
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    Towards an Implementation‐STakeholder Engagement Model (I‐STEM) for improving health and social care services
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