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2061“…Here we consider a structure to be tantamount to the noncrossing Watson-Crick and G-U-base pairings (secondary structure) and additional cross-serial base pairs. …”
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2062“…We then study the successive jumps of the coverage function, and show that they can be encoded as a random tree that is approximately a Galton-Watson tree with generation-dependent geometric offspring distributions whose parameters can be computed. …”
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2063“…A completely 2′-F/2′-OMe modified dimeric RNA construct adopts an antiparallel double-helical structure consisting of 19 Watson–Crick base pairs with additional 3′ UU overhangs and a 5′ phosphate group on the antisense strand. …”
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2064por Elefant, Naama, Berger, Amnon, Shein, Harel, Hofree, Matan, Margalit, Hanah, Altuvia, Yael“…RepTar is based on identification of repetitive elements in 3′-UTRs and is independent of both evolutionary conservation and conventional binding patterns (i.e. Watson–Crick pairing of ‘seed’ regions). The modularity of RepTar enables the prediction of targets with conventional seed sites as well as rarer targets with non-conventional sites, such as sites with seed wobbles (G-U pairing in the seed region), 3′-compensatory sites and the newly discovered centered sites. …”
Publicado 2011
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2065“…Interestingly, a large part of the structure is comprised of regular Watson-Crick and GU wobble base pairs. This and the increased amount of available genomes have made it possible to employ structure-based methods for genomic screens. …”
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2066“…We find that, with increasing fidelity (relative rate of base-extension for Watson-Crick versus mismatched base pairs), replications without enzymes, with ribozymes, and with protein-based polymerases are above, near, and below a critical point, respectively. …”
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2067“…In addition, it is clear that unintended genes with complementarities only in the seed region (positions 2–8) are also downregulated by off-target effects. siRNA efficiency is mainly determined by the Watson–Crick base-pairing stability formed between the siRNA seed region and target mRNA. siRNAs with a low seed-target duplex melting temperature (T(m)) have little or no seed-dependent off-target activity. …”
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2068por Scali, Jacqueline, Gandubert, Catherine, Ritchie, Karen, Soulier, Maryvonne, Ancelin, Marie-Laure, Chaudieu, Isabelle“…Lifetime psychiatric symptoms were assessed retrospectively using two standardized psychiatric examinations (Mini International Neuropsychiatric Interview and Watson's Post-Traumatic Stress Disorder Inventory). …”
Publicado 2012
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2069por Bhamra, Inder, Compagnone-Post, Patricia, O’Neil, Ian A., Iwanejko, Lesley A., Bates, Andrew D., Cosstick, Richard“…The fact that no 8-nitroG·G base pairing is seen in the primer extension products suggests that the polymerases may discriminate against this pairing system on the basis of its poor geometric match to a Watson–Crick pair.…”
Publicado 2012
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2070“…METHODS: Multistage cluster sampling was utilized to recruit 125 preclinical (1(st), 2(nd) and 3(rd) year of study) students in Yazd Shaheed Sadoughi University of Medical Sciences in Yazd, Iran. The Watson-Glaser Critical Thinking Appraisal (WGCTA) was applied to collect data. …”
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2071“…Therapeutic small interfering RNAs (siRNAs) are composed of chemically modified nucleotides, which enhance RNA stability and increase affinity in Watson–Crick base pairing. However, the precise fate of such modified nucleotides once the siRNA is degraded within the cell is unknown. …”
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2072por Fukunaga, Junichi, Nomura, Yusuke, Tanaka, Yoichiro, Amano, Ryo, Tanaka, Taku, Nakamura, Yoshikazu, Kawai, Gota, Sakamoto, Taiichi, Kozu, Tomoko“…All the isolated aptamers were found to contain the conserved sequence motif 5′-NNCCAC-3′ and 5′-GCGMGN′N′-3′ (M:A or C; N and N′ form Watson–Crick base pairs). The motif contains one AC mismatch and one base bulged out. …”
Publicado 2013
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2073por Li, Deyu, Fedeles, Bogdan I., Shrivastav, Nidhi, Delaney, James C., Yang, Xuedong, Wong, Cintyu, Drennan, Catherine L., Essigmann, John M.“…When viewed together with previous work, the experimental data herein demonstrate that AlkB is able to repair all simple N-alkyl adducts occurring at the Watson–Crick base pairing interface of the four DNA bases, confirming AlkB as a versatile gatekeeper of genomic integrity under alkylation stress.…”
Publicado 2013
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2074por Aeschbacher, Thomas, Schmidt, Elena, Blatter, Markus, Maris, Christophe, Duss, Olivier, Allain, Frédéric H.-T., Güntert, Peter, Schubert, Mario“…Statistics of resonances from regularly Watson–Crick base-paired RNA revealed highly characteristic chemical shift clusters. …”
Publicado 2013
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2075“…Specifically, G4 folding was observed to be inhibited by the presence of multiple-cytosine tracks, located in the candidate’s genomic context, that adopted a Watson–Crick base-paired structure. Clearly, the neighbouring sequences of a PG4 may influence its folding. …”
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2076“…However, the C8-dG-IQ adopted the syn conformation placing the Watson−Crick edge of the modified dG into the major groove. …”
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2077por Santi Xavier, Patrícia, Perez Vogt, Bárbara, Cuadrado Martin, Luis, Vaninni, Francieli, Araújo Antunes, Aline, Ponce, Daniela, Costa Teixeira Caramori, Jacqueline, dos Santos e Silva Martin, Rosana, da Silva Franco, Roberto Jorge, Barretti, Pasqual“…METHODS: Volume overload was calculated as the difference between total body water (TBW) measured by bioimpedance and TBW estimated by the Watson formula in chronic stable hemodialysis patients. …”
Publicado 2014
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2078por Sharma, Sunny, Langhendries, Jean-Louis, Watzinger, Peter, Kötter, Peter, Entian, Karl-Dieter, Lafontaine, Denis L.J.“…Efficient 18S rRNA acetylation in helix 45 involves, in human cells, the vertebrate-specific box C/D snoRNA U13, which, we suggest, exposes the substrate cytosine to modification through Watson–Crick base pairing with 18S rRNA precursors during small subunit biogenesis. …”
Publicado 2015
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2079por Zirbel, Craig L., Roll, James, Sweeney, Blake A., Petrov, Anton I., Pirrung, Meg, Leontis, Neocles B.“…Isostericity relations between non-Watson–Crick basepairs are used in scoring sequence variants. …”
Publicado 2015
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2080“…The two carboxyl groups of adipic acid interact with the Watson–Crick face of the BA molecules through O—H⋯N and N—H⋯O hydrogen bonds, generating an R (2) (2)(8) ring motif. …”
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