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2121“…We addressed this knowledge gap through using an improved statistical stochastic method based on the Galton–Watson branching process, considering both symptomatic and asymptomatic cases. …”
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2122“…By introducing a photolabile group at these specific sites, we achieved optical control of Cas9 activity without disrupting the Watson–Crick base pairing. We further examined our design through CRISPR-mediated gene activation and nuclease cleavage in living cells and successfully manipulated the gene expression by using light irradiation. …”
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2123por Xu, Xiaochen, Egger, Michaela, Chen, Hao, Bartosik, Karolina, Micura, Ronald, Ren, Aiming“…The binding-pocket is determined by the highly conserved junctional sequence J1 between stem P1 and P2a, and engages a long-distance Watson–Crick base pair to junction J2. Xanthine inserts between a G–U pair from the major groove side and is sandwiched between base triples. …”
Publicado 2021
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2124“…The Watson–Crick base pair proton transfer tautomers would be widely considered as a source of spontaneous mutations in DNA replication if not for their short lifetimes and thermodynamic instability. …”
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2125“…Amaranthus palmeri S. Watson (Palmer amaranth) is considered a problematic and troublesome weed species in many crops in the USA, partly because of its ability to evolve resistance to herbicides. …”
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2126“…The intervention group received a 6-h workshop based on Watson's human care theory using a collaborative and role-playing approach and 1-month follow-up period through presenting weekly preplanned care and caregiving scenarios. …”
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2127por Monachello, Dario, Lauraine, Marc, Gillot, Sandra, Michel, François, Costa, Maria“…This pairing adopts a Watson–Crick geometry and is essential for intron mobility, most probably by driving unwinding of the DNA duplex. …”
Publicado 2021
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2128“…BACKGROUND: The function of non-coding RNA sequences is largely determined by their spatial conformation, namely the secondary structure of the molecule, formed by Watson–Crick interactions between nucleotides. Hence, modern RNA alignment algorithms routinely take structural information into account. …”
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2129por Mulenga, Chola, Sviben, Sanja, Chandwe, Kanta, Amadi, Beatrice, Kayamba, Violet, Fitzpatrick, James A. J., Mudenda, Victor, Kelly, Paul“…CLE videos were evaluated, employing the Watson score to determine severity of leakiness. Morphometry was carried out on well-orientated mucosa and 3 biopsies were examined by electron microscopy. …”
Publicado 2022
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2130por Chand, Santanu, Alahmed, Othman, Baslyman, Walaa S., Dey, Avishek, Qutub, Somayah, Saha, Ranajit, Hijikata, Yuh, Alaamery, Manal, Khashab, Niveen M.“…They feature an accessible Watson–Crick Ade face that is available for further hydrogen bonding and can load single-stranded DNA (ssDNA) with 13 and 41% efficiency for KBM-1 and KBM-2, respectively. …”
Publicado 2022
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2131por Boris-Lawrie, Kathleen, Singh, Gatikrushna, Osmer, Patrick S., Zucko, Dora, Staller, Seth, Heng, Xiao“…TMG-cap is blocked from Watson:Crick base pairing and disqualified from participating in secondary structure. …”
Publicado 2022
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2132por Ruggiero, Emanuela, Lavezzo, Enrico, Grazioli, Marco, Zanin, Irene, Marušič, Maja, Plavec, Janez, Richter, Sara N., Toppo, Stefano“…The DNA secondary structures that deviate from the classic Watson and Crick base pairing are increasingly being reported to form transiently in the cell and regulate specific cellular mechanisms. …”
Publicado 2022
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2133por Satange, Roshan, Kao, Shih-Hao, Chien, Ching-Ming, Chou, Shan-Ho, Lin, Chi-Chien, Neidle, Stephen, Hou, Ming-Hon“…Changes in the former with GpC and CpG steps separated by a A:G or G:A mismatch or in a native DNA with canonical G:C and C:G base pairs, result in significant asymmetric backbone twists through staggered intercalation and base pair modulations. A wobble or Watson–Crick base pair at the two drug-binding interfaces can result in a single-stranded ‘chair-shaped’ DNA duplex with a straight helical axis. …”
Publicado 2022
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2134“…The low-energy conformation always maintains Watson–Crick base pairing between 5S,6R-Tg and A19, and 5S-Tg base flipping is accompanied by a small barrier of ca. 2.0 K(B)T (T = 298 K). …”
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2135por Jastrzębska, Katarzyna, Maciaszek, Anna, Dolot, Rafał, Tomaszewska-Antczak, Agnieszka, Mikołajczyk, Barbara, Guga, Piotr“…Melting experiments performed for their complexes with Watson–Crick paired DNA matrix showed that (M)N(PS) or N(PS) units decrease the thermal stability of the duplexes (ΔT(m) = −0.5 ÷ −5.5 °C per modification) regardless of the absolute configuration of the P-atoms. …”
Publicado 2022
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2136por KIATKITROJ, Kanpitcha, ARPHORN, Sara, TANGTONG, Chaiyanun, MARUO, Suchinda Jarupat, ISHIMARU, Tomohiro“…Bioelectrical impedance analysis was used to assess body mass index and body fat percentage. Watson formula equations were used to estimate total body water. …”
Publicado 2021
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2137por Doherty, Erin E, Karki, Agya, Wilcox, Xander E, Mendoza, Herra G, Manjunath, Aashrita, Matos, Victorio Jauregui, Fisher, Andrew J, Beal, Peter A“…This study shows how non-Watson–Crick pairing in duplex RNA can facilitate ADAR editing enabling the design of next generation guide strands for therapeutic RNA editing.…”
Publicado 2022
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2138“…Lastly, we trained the deep learning model (Watson) using these captured tone values to determine the social isolation index of the individual. …”
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2139“…The free energy difference between HG and Watson–Crick (WC) base pairs has been computed in previous studies. …”
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2140