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2401“…We also review nonparametric methods including Nadaraya-Watson estimator, reproducing kernel Hilbert space, support vector machine regression, and neural networks. …”
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2402por Assis, Raquel“…This problem can be directly addressed by studying the evolution of RNA secondary structures, for which there is constraint to maintain pairing between Watson-Crick (WC) sites. Replacement of a nucleotide at one site of a WC pair reduces fitness by disrupting binding, which can be restored via a compensatory replacement at the interacting site. …”
Publicado 2014
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2403“…Our results indicate that the PSD-95 mRNA G-rich region folds into alternate G quadruplex conformations that coexist in equilibrium. miR-125a forms a stable complex with PSD-95 mRNA, as evident by characteristic Watson–Crick base-pairing that coexists with one of the G quadruplex forms, suggesting a novel mechanism for G quadruplex structures to regulate the access of miR-125a to its binding site.…”
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2404“…Predicted overall tumbling times are ∼20% faster than those inferred from analysis of NMR data and follow the same trend when temperature and ionic strength is varied. The Watson–Crick stem and the “canonical” UUCG loop structure are maintained in most simulations including the characteristic syn conformation along the glycosidic bond of G9, although some key hydrogen bonds in the loop are partially disrupted. …”
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2405por Miao, Zhichao, Adamiak, Ryszard W., Blanchet, Marc-Frédérick, Boniecki, Michal, Bujnicki, Janusz M., Chen, Shi-Jie, Cheng, Clarence, Chojnowski, Grzegorz, Chou, Fang-Chieh, Cordero, Pablo, Cruz, José Almeida, Ferré-D'Amaré, Adrian R., Das, Rhiju, Ding, Feng, Dokholyan, Nikolay V., Dunin-Horkawicz, Stanislaw, Kladwang, Wipapat, Krokhotin, Andrey, Lach, Grzegorz, Magnus, Marcin, Major, François, Mann, Thomas H., Masquida, Benoît, Matelska, Dorota, Meyer, Mélanie, Peselis, Alla, Popenda, Mariusz, Purzycka, Katarzyna J., Serganov, Alexander, Stasiewicz, Juliusz, Szachniuk, Marta, Tandon, Arpit, Tian, Siqi, Wang, Jian, Xiao, Yi, Xu, Xiaojun, Zhang, Jinwei, Zhao, Peinan, Zok, Tomasz, Westhof, Eric“…However, the prediction accuracy for non-Watson–Crick interactions, key to proper folding of RNAs, is low and some predicted models had high Clash Scores. …”
Publicado 2015
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2406“…We report exceptionally well-preserved plant remains ascribed to the extinct conifer Glenrosa J. Watson et H.L. Fisher emend. V. Srinivasan inside silica-rich nodules from the Cenomanian of the Font-de-Benon quarry, Charente-Maritime, western France. …”
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2407por Sel, Guillermo Del, Máspero, Guillermo, Sel, Nicolás Del, Russo, Leonardo, Sel, Juan Del“…Fractures classified with AO and Watson Jones classifications. In all cases close reduction and percutaneous osteosynthesis with conic,canulated, compressive, full threaded screws of 3,5 and/or 5 mm diameter under fluoroscopic and arthroscopic assistance, was performed. …”
Publicado 2015
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2408“…Unlike terminal loops, splicing activities of internal loop mutants were predicted by their intramolecular Watson-Crick interactions with the antiparallel strand of the MIR hairpin rather than by frequencies of corresponding trinucleotides in splicing silencers/enhancers. …”
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2409“…CONTRAINDICATIONS: Non-displaced acetabular fractures. SURGICAL TECHNIQUE: Watson-Jones approach to provide accessibility to the anterior and supraacetabular part of the iliac bone. …”
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2410por Algasaier, Sana I., Exell, Jack C., Bennet, Ian A., Thompson, Mark J., Gotham, Victoria J. B., Shaw, Steven J., Craggs, Timothy D., Finger, L. David, Grasby, Jane A.“…Placement of the scissile phosphate diester in the active site required the presence of divalent metal ions, a free 5′-flap (if present), a Watson-Crick base pair at the terminus of the reacting duplex, and the intact secondary structure of the enzyme helical cap. …”
Publicado 2016
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2411“…The BP-dG adducted DNA substrate maintains a Watson–Crick (BP-dG:dC) base pair within the active site, governing correct nucleotide insertion opposite the bulky adduct. …”
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2412“…Nucleotide variations were much less likely to occur in the consecutive Watson-Crick anchor region, indicating a very strong bias against G:U base pairs in this region. …”
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2413por Dia, Mahendra, Wehner, Todd C, Perkins-Veazie, Penelope, Hassell, Richard, Price, Daniel S, Boyhan, George E, Olson, Stephen M, King, Stephen R, Davis, Angela R, Tolla, Gregory E, Bernier, Jerome, Juarez, Benito“…'Stone Mountain', 'Tom Watson', 'Crimson Sweet' and 'Minilee' were among the best genotypes for lycopene content, sugar content and hollowheart resistance. …”
Publicado 2016
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2414por Crowther, Claire V., Jones, Laura E., Morelli, Jessica N., Mastrogiacomo, Eric M., Porterfield, Claire, Kent, Jessica L., Serra, Martin J.“…The identity of XY (where XY are Watson–Crick base pairs) and the total number of base pairs in the terminal and central stems were varied. …”
Publicado 2017
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2415“…P:Z nucleobase pairs follow standard rules for Watson–Crick base pairing but have rearranged hydrogen bonding donor and acceptor groups. …”
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2416por Chu, Wai Keung, Edge, Peter, Lee, Ho Suk, Bansal, Vikas, Bafna, Vineet, Huang, Xiaohua, Zhang, Kun“…A microfluidic processor is used to separate the Watson and Crick strands of the double-stranded chromosomal DNA in a single cell and to randomly partition megabase-size DNA strands into multiple nanoliter compartments for amplification and construction of barcoded libraries for sequencing. …”
Publicado 2017
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2417“…Hip was approached through Watson-Jones approach. The head and neck was found to be dislocated and lying close to obturator foramen. …”
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2418Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphomapor Liu, Jianyun, Gallo, Richard M., Khan, Masood A., Renukaradhya, Gourapura J., Brutkiewicz, Randy R.“…Mutations in NF1 are linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. In terms of antitumor immunity, CD1d-dependent natural killer T (NKT) cells play an important role in the innate antitumor immune response. …”
Publicado 2018
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2419por Contractor, Pritesh, Gandhi, Abhishek, Solanki, Gajendra, Shah, Priyanka A., Shrivastav, Pranav S.“…Entire data processing was done using Watson LIMS™ software which provided excellent data integrity and high throughput with improved operational efficiency. …”
Publicado 2017
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2420por Ugland, Terje O, Haugeberg, Glenn, Svenningsen, Svein, Ugland, Stein H, Berg, Øystein H, Hugo Pripp, Are, Nordsletten, Lars“…Participants were allocated to an uncemented hemiarthroplasty inserted through a direct lateral (Hardinge) approach or an anterolateral (modified Watson-Jones) approach. The 51 patients (mean age 83 (70–90) years, 33 women) were measured by dual-energy X-ray absorptiometry (DXA) to assess changes in periprosthetic bone mineral density (BMD). …”
Publicado 2018
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