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401Publicado 2014Tabla de Contenidos: “…Simpson (1951) -- Molecular structure of nucleic acids : a structure for deoxyribose nucleic acid / J.D. Watson and F.H.C. Crick (1953) -- Hybridization as an evolutionary stimulus / E. …”
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402por Hammond, Nicholas B., Tolbert, Blanton S., Kierzek, Ryszard, Turner, Douglas H., Kennedy, Scott D.“…For loops bounded by Watson−Crick pairs, the AG and Watson−Crick pairs are all head-to-head imino-paired (cis Watson−Crick/Watson−Crick). …”
Publicado 2010
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403por Thakku, Sri Gowtham, Lirette, Jackson, Murugesan, Kanagavel, Chen, Julie, Theron, Grant, Banaei, Niaz, Blainey, Paul C., Gomez, James, Wong, Sharon Y., Hung, Deborah T.“…We thus demonstrate the potential for translating WATSON to a lateral flow platform. WATSON demonstrates the ability to capitalize on the strengths of targeting microbial cfDNA to address the need for point-of-care diagnostic tests for infectious diseases.…”
Publicado 2023
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404“…A total of 519 consecutive patients, admitted to psychiatric wards of two different hospitals, were screened for evidence of increased excretion of porphobilinogen in the urine by original Watson Schwartz test and modified Watson Schwartz test supported with quantitative estimation of porphobilinogen by Remington's method in search of cases of acute porphyria amongst psychiatric patients. …”
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405“…CONCLUSIONS: The ECW(BIA)/TBW(Watson) ratio was independently associated with adverse renal outcomes. …”
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406por Spasic, Aleksandar, Kennedy, Scott D., Needham, Laura, Manoharan, Muthiah, Kierzek, Ryszard, Turner, Douglas H., Mathews, David H.“…This differs markedly from the internal loops, (5′-GAGC-3′)(2), (5′-AAGU-3′)(2), and (5′-UAGG-3′)(2), which all have cis-Watson–Crick/Watson–Crick AG “imino” pairs flanked by cis-Watson–Crick/Watson–Crick canonical pairs resulting in maximal hydrogen bonding. …”
Publicado 2018
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407“…The two most stable structures had trans glycosidic bonds, but distinct pairing geometries, i.e. either Watson–Crick Hoogsteen (transWH) or Watson–Crick Watson–Crick (transWW) with stability of transWH > transWW. …”
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408“…Wobble GU pairs (or G•U) occur frequently within double-stranded RNA helices interspersed between standard G=C and A-U Watson–Crick pairs. Another type of G•U pair interacting via their Watson–Crick edges has been observed in the A site of ribosome structures between a modified U34 in the tRNA anticodon triplet and G + 3 in the mRNA. …”
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409por Jacob, Christine“…However contrary to the classical Bienaymé-Galton-Watson or asymptotically Bienaymé-Galton-Watson setting, where the asymptotic behavior of the process, as time tends to infinity, is well understood, the asymptotic behavior of this general process is a new question. …”
Publicado 2010
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410por Manickam, Nandini, Nag, Nabanita, Abbasi, Aleeza, Patel, Kishan, Farabaugh, Philip J.“…The ribosome appears to discriminate this efficiently against any pair with non-Watson–Crick geometry. This extreme accuracy may be necessary to allow discrimination against the errors involving near Watson–Crick pairing.…”
Publicado 2014
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411por Rozov, Alexey, Demeshkina, Natalia, Westhof, Eric, Yusupov, Marat, Yusupova, Gulnara“…These structures show that in the codon–anticodon duplex, a G·U mismatch adopts the Watson–Crick geometry, indicating a shift in the tautomeric equilibrium or ionization of the nucleobase. …”
Publicado 2015
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412por Pelletier, Jonathan H., Au, Alicia K., Fuhrman, Dana, Zullo, James, Thompson, Ann E., Clark, Robert S.B., Horvat, Christopher“…ICU antimicrobial use was not correlated with risk-adjusted mortality assessed using IBM-Watson. A risk model incorporating laboratory data available in PHIS+ significantly outperformed IBM-Watson (c-statistic 0.940 [95% confidence interval 0.933–0.947] versus 0.891 [0.881–0.901]; P < 0.001, area under the precision recall curve 0.561 versus 0.297). …”
Publicado 2021
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413por Steger, Gerhard“…Here we model the important structural features of the domain and show that it contains an internal loop of two Y · Y cis Watson-Crick/Watson-Crick (cWW) pairs, an asymmetric internal loop including a cWW and a trans Watson/Hoogsteen pair, and a thermodynamically quite stable hairpin loop with several stacking interactions. …”
Publicado 2017
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414“…The purpose of the present study was to determine the prevalence of limping following the posterior approach, the direct lateral approach, and the modified anterolateral Watson-Jones approach for primary total hip replacement, performed by 1 surgeon. …”
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415“…In addition, the important role of non-classical C–H⋯N/O bonds for the stabilization of base pairs was revealed, especially the role of C–H⋯O bonds in Watson Crick base pairs. Hydrogen bonding in Watson Crick base pairs modeled in the DNA via a QM/MM approach showed that the DNA environment increases the strength of the central N–H⋯N bond and the C–H⋯O bonds, and at the same time decreases the strength of the N–H⋯O bond. …”
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417por Nikolova, Evgenia N., Kim, Eunae, Wise, Abigail A., O’Brien, Patrick J., Andricioaei, Ioan, Al-Hashimi, Hashim M.“…Sequence-directed variations in the canonical DNA double helix structure that retain Watson-Crick base-pairing play important roles in DNA recognition, topology, and nucleosome positioning. …”
Publicado 2011
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418“…The internal loop containing the 3′ splice site has a dynamic guanosine and a stable imino (cis Watson–Crick/Watson–Crick) GA pair. The adenine bulge also appears to be dynamic with the A either stacked in the stem or forming a base triple with a Watson–Crick GC pair. …”
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419por Harb, Nidal H, Said, Patricia A, Gusta, Shirley L, Wesson, Amanda M, Brautigam, Jordan D, Lemke, Jon H, DeLessio, Stephen T, Cropper, Douglas P, Shammas, Nicolas W“…Genesis Health System was recognized as an IBM Watson Health 15 Top Health System for two consecutive years in 2020 and 2021. …”
Publicado 2022
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420por Giorgio, Marco“…However, antioxidant compounds are still disappointingly distant from any clinical application, so that Jim Watson has declared that antioxidant supplementation may have caused more cancers than it has prevented Watson J ((2013) Oxidants, antioxidants and the current incurability of metastatic cancers Open Biol 3 DOI: 10.1098/rsob.120144). …”
Publicado 2015
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