“…Using temperature-dependent (20°C–65°C) NMR relaxation dispersion, we show that m(6)A pairs with uridine with the methylamino group in the anti conformation to form a Watson-Crick base pair that transiently exchanges on the millisecond timescale with a singly hydrogen-bonded low-populated (1%) mismatch-like conformation in which the methylamino group is syn. …”
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“…This article comments on: González FG, Capella M, Ribichich KF, Curín F, Giacomelli JI, Ayala F, Watson G, Otegui ME, Chan RL. 2019. Field-grown transgenic wheat expressing the sunflower gene HaHB4 significantly outyields the wild type. …”
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“…We prove a law of large numbers for the range of rotor walks with random initial configuration on regular trees and on Galton–Watson trees. We also show the existence of the speed for such rotor walks. …”
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“…When the complementary C-rich strand is present, a mixture of both G-quadruplex structures and Watson–Crick duplex is observed, the duplex being the major species. …”
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“…It is intriguing to find out that isoflavones can stabilize the G-quadruplex structure but destabilize its corresponding Watson–Crick duplex and this discriminated interaction is intensified by molecular crowding environments. …”
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“…We hypothesize that these quadruplex structures can be formed by many different DNA sequences, but its observation in linear oligonucleotides is usually hampered by competing Watson–Crick duplexes.…”
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“…The theory of X-ray diffraction from ideal, rigid helices allowed Watson and Crick to unravel the DNA structure, thereby elucidating functions encoded in it. …”
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“…Pseudo pairs between the Watson–Crick edge of guanine and Asp are frequently observed. …”
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“…In the Watson genome, we identified 752 VNTRs with pattern sizes ranging from 7 to 84 nt. …”
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“…In this framework, canonical Watson-Crick, non-Watson-Crick base-pairing and base-stacking interactions can be unambiguously identified within a well-defined interaction shell. …”
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“…Our analysis indicated that (i) cosolutes increased the free energy of water molecules around DNA by disrupting water–water interactions, (ii) ethylene glycol more effectively disrupted water–water interactions around Watson–Crick base pairs than those around G-quartets or non-paired bases, (iii) due to the negative electrostatic potential there was a thicker hydration shell around G-quartets than around Watson–Crick-paired bases. …”
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“…Tautomeric and anionic Watson-Crick-like mismatches play important roles in replication and translation errors through mechanisms that are not fully understood. …”
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“…Furthermore, we have established that heterochiral α‐dC–dC base pairs can approach the stability of a Watson–Crick pair, whereas homochiral dC–dC pairs are significantly less stable. …”
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“…Under molecular crowding conditions, Watson–Crick base pairs and Hoogsteen base pairs were destabilized and stabilized, respectively. …”
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“…Form 1 is a three-G-tetrad-layered (3+1) G-quadruplex containing a propeller loop, a lateral loop and a stem-loop made up of three G•C Watson–Crick base pairs. On the other hand, Form 2 is an anti-parallel G-quadruplex comprising two G-tetrads and a G•C•G•C tetrad; the structure has three lateral loops with the middle stem-loop made up of two Watson-Crick G•C base pairs. …”
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“…The Watson–Crick A·T and G·C base pairs are not only electronically complementary, but also photochemically complementary. …”
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“…The Mn(2+)-bound structures reveal that, whereas the O6Me·dCTP–Mn(2+) complex assumes the similar altered conformation, the O6MeG·dTTP–Mn(2+) complex adopts a catalytically competent state with a closed protein conformation and pseudo-Watson–Crick base pair. On the basis of these observations, we conclude that polβ slows nucleotide incorporation opposite O6MeG by inducing an altered conformation suboptimal for catalysis and promotes mutagenic replication by allowing Watson–Crick-mode for O6MeG·T but not for O6MeG·C in the enzyme active site. …”
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“…Within this opinion article, I provide a brief historical account of the discovery of the Watson-Crick DNA model and introduce another neglected model of DNA. …”
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“…Micropatterning is a process to precisely deposit molecules, typically proteins, onto a substrate of choice with micrometer resolution. Watson et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202009063) describe an innovative yet accessible strategy to enable the reproducible micropatterning of virtually any protein while maintaining its biological activity.…”
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