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741por Jiang, Fei, Jiang, Yong, Zhi, Hui, Dong, Yi, Li, Hao, Ma, Sufeng, Wang, Yilong, Dong, Qiang, Shen, Haipeng, Wang, Yongjun“…We conclude with discussion about pioneer AI systems, such as IBM Watson, and hurdles for real-life deployment of AI.…”
Publicado 2017
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742por Arenas-Guerrero, Paloma, Delgado, Ángel V., Donovan, Kevin J., Scott, Kenneth, Bellini, Tommaso, Mantegazza, Francesco, Jiménez, María L.“…We analyse the measured transient birefringence with three approaches: the stretched-exponential, Watson-Jennings, and multi-exponential methods. These are applied to six different types of rod-like and planar particles: PTFE rods, goethite needles, single- and double-walled carbon nanotubes, sodium montmorillonite particles and gibbsite platelets. …”
Publicado 2018
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743“…In all cases, fidelity of Watson-Crick base pairing between the two strands was retained. …”
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744“…We analyzed the averaged frequencies of the split components on the basis of the Watson A-reduced Hamiltonian, neglecting the effect of the internal rotations. …”
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745“…Here we show that translesion synthesis (TLS) opposite 1,N(6)-ethenodeoxyadenosine (εdA), which disrupts Watson–Crick base pairing, occurs via Polι/Polζ-, Rev1-, and Polθ-dependent pathways. …”
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746por Backer, Adam S., Biebricher, Andreas S., King, Graeme A., Wuite, Gijs J. L., Heller, Iddo, Peterman, Erwin J. G.“…These results provide the first experimental evidence that S-DNA has substantially inclined base pairs relative to those of the standard (Watson-Crick) B-DNA conformation.…”
Publicado 2019
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747por Kousaalya, Adhimoolam Bakthavachalam, Beyene, Shiferaw D., Ayalew, Beshah, Pilla, Srikanth“…The proposed model is based on the Langmuir-Hinshelwood-Hougen-Watson (L-H-H-W) postulates and considers the adsorption of formic acid on the catalyst as the rate-determining step. …”
Publicado 2019
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748por Montemayor, Eric J., Virta, Johanna M., Hagler, Lauren D., Zimmerman, Steven C., Butcher, Samuel E.“…The CUG repeat contains a U–U mismatch sandwiched between Watson–Crick pairs. Additionally, the center of the helix contains a dimerized UUCG motif with tandem pyrimidine (U–C/C–U) mismatches flanked by U–G wobble pairs. …”
Publicado 2019
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749por Kumari, Nitu, Vartak, Supriya V., Dahal, Sumedha, Kumari, Susmita, Desai, Sagar S., Gopalakrishnan, Vidya, Choudhary, Bibha, Raghavan, Sathees C.“…DNA, the fundamental unit of human cell, generally exists in Watson-Crick base-paired B-DNA form. Often, DNA folds into non-B forms, such as four-stranded G-quadruplexes. …”
Publicado 2019
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750por Colizzi, Francesco, Perez-Gonzalez, Cibran, Fritzen, Remi, Levy, Yaakov, White, Malcolm F., Penedo, J. Carlos, Bussi, Giovanni“…The opening of a Watson–Crick double helix is required for crucial cellular processes, including replication, repair, and transcription. …”
Publicado 2019
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751por Kim, Haseong“…In the biosciences field in Korea, such technologies have become known to the local public with the introduction of the AI doctor Watson in large number of hospitals. Additionally, AlphaFold, a technology resembling the AI AlphaGo for the game Go, has surpassed the limit on protein folding predictions—the most challenging problems in the field of protein biology. …”
Publicado 2019
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752“…Inspired by the outstanding performance and selectivity of DNA in living systems, scientists are increasingly employing Watson−Crick nucleobase pairing to control the structure and properties of self‐assembled materials. …”
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753por Gasser, Catherina, Delazer, Isabel, Neuner, Eva, Pascher, Katharina, Brillet, Karl, Klotz, Sarah, Trixl, Lukas, Himmelstoß, Maximilian, Ennifar, Eric, Rieder, Dietmar, Lusser, Alexandra, Micura, Ronald“…We have developed the hydrazine/NH(4)Cl/OsO(4)‐based conversion of 6‐thioguanosine (6sG) into A′, where A′ constitutes a 6‐hydrazino purine derivative. A′ retains the Watson–Crick base‐pair mode and is efficiently decoded as adenosine in primer extension assays and in RNA sequencing. …”
Publicado 2020
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754Characterizing Pain Points in Clinical Data Management and Assessing the Impact of Mid-Study Updatespor Harper, Beth, Smith, Zachary, Snowdon, Jane, DiCicco, Robert, Hekmat, Rezzan, Van Willis, Weeraratne, Dilhan, Getz, Ken“…METHODS: Tufts Center for the Study of Drug Development (Tufts CSDD)—in collaboration with IBM Watson Health—conducted an online global survey between September and October 2020. …”
Publicado 2021
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755por Diaferia, Carlo, Avitabile, Concetta, Leone, Marilisa, Gallo, Enrico, Saviano, Michele, Accardo, Antonella, Romanelli, Alessandra“…Forces that stabilize the “suprastructures” typically are hydrogen bonds or aromatic interactions; in case of nucleic acids, Watson‐Crick pairing drives self‐assembly while, in case of peptides, backbone hydrogen bonds and interactions between aromatic side chains trigger the formation of structures, such as nanotubes or ribbons. …”
Publicado 2021
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756por Lomidze, Levan, Yang, Mengkun, Khutsishvili, David, Metreveli, Nunu, Musier-Forsyth, Karin, Kankia, Besik“…Taken together, these data support the formation of a stable programmable homopolymeric tmDNA architecture, which may have been a precursor to the modern-day Watson–Crick DNA duplex.…”
Publicado 2022
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757“…However, the strong binding energy of Watson–Crick base pairing that underlies this specificity also causes the DNA dehybridization rate to depend sensitively on sequence length and temperature. …”
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758por Lin, Xiwu, Lofland, Jennifer, Zhang, Ling, Sloan, Sheldon, Chamaa, Laila, Marano, Colleen, Plevy, Scott“…METHODS: This analysis of real-world data from IBM Watson Health Commercial Claims and Encounters Database included patients with the first claim of inflammatory bowel disease (IBD) between 2007 and 2014. …”
Publicado 2020
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759por Thadke, Shivaji A., Hridya, V.M., Perera, J. Dinithi R., Gil, Roberto R., Mukherjee, Arnab, Ly, Danith H.“…An impressive array of antigene approaches has been developed for recognition of double helical DNA over the past three decades; however, few have exploited the ‘Watson–Crick’ base-pairing rules for establishing sequence-specific recognition. …”
Publicado 2018
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