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1101por Bao, Penghui, Wu, Qi-Jia, Yin, Ping, Jiang, Yanfei, Wang, Xu, Xie, Mao-Hua, Sun, Tao, Huang, Lin, Mo, Ding-Ding, Zhang, Yi“…GTP-mediated facilitation requires C2 amino and C6 carbonyl groups on the Watson–Crick edge of the base but not the phosphate or sugar groups, suggesting that the base triple interactions between GTP and the binding site are important for the subsequent ωG binding. …”
Publicado 2008
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1102“…However, the excised strand remains annealed to the plasmid through non-covalent Watson–Crick base-pairing; its removal, therefore, requires a heat–cool cycle in the presence of an exactly complementary competitor DNA. …”
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1103por Capua, Christopher J., Hopson, Nick P., Stewart, C. Malcolm M., Johnston, G. Robert, O'Neill, Kim L., Schaalje, G. Bruce, Lee, Christopher M., Booth, Gary M.“…This study reports that extracts of Atriplex confertifolia (Torr. and Frem.) S. Watson (Chenopodiaceae), a native North American plant (also known as shadscale or saltbush), has significant bioactivity against human breast cancer cell lines MCF-7, MDA-MB 435, MDA-MB 231, and HeLa cells (cervical cancer cells). …”
Publicado 2010
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1104“…Analysis of the aptamer consensus sequences suggested that the conserved segments could form duplexes via Watson–Crick base-pairing with preferred sequences in one strand of the DNA, assuming the aptamer invaded the duplex. …”
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1105por Rodriguez, Raphaël, Miller, Kyle M., Forment, Josep V., Bradshaw, Charles R., Nikan, Mehran, Britton, Sébastien, Oelschlaegel, Tobias, Xhemalce, Blerta, Balasubramanian, Shankar, Jackson, Stephen P.“…Guanine-rich DNA sequences that can adopt non-Watson-Crick structures in vitro are prevalent in the human genome. …”
Publicado 2012
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1106“…This work suggests that the bulky hydrophobic groups may locally influence the formation of non-Watson–Crick structures from otherwise complementary sequences. …”
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1107“…They guide ribonucleoprotein complexes to their target nucleic acids by Watson–Crick base pairing. We report here that current techniques for small RNA detection and library generation are biased by formation of RNA duplexes. …”
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1108“…Ever since the introduction of the Watson-Crick model, numerous efforts have been made to fully characterize the digital information content of the DNA. …”
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1109por Gudanis, Dorota, Popenda, Lukasz, Szpotkowski, Kamil, Kierzek, Ryszard, Gdaniec, Zofia“…The 8-bromoguanosine ((Br)G)-modified molecule GC(Br)GGCGGC forms a duplex in solution and self-associates via the major groove to form a four-stranded, antiparallel (GC(Br)GGCGGC)(4) RNA quadruplex with (Br)G3:G6:(Br)G3:G6 tetrads sandwiched between mixed G:C:G:C tetrads. Self-association of Watson–Crick duplexes to form a four-stranded structure has previously been predicted; however, no experimental evidence was provided. …”
Publicado 2016
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1110“…The amino group containing phosphoramidite was used together with complementary single-strand DNA templates that influenced the Watson–Crick base-pairing equilibrium in the mixture with a set of aldehyde modified nucleobases. …”
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1111“…The origin dsDNA inside the narrower AAA+ domain channel shows partial melting due to the compression of the two phosphate backbones, forcing Watson-Crick base-pairs within the duplex to flip outward. …”
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1112“…Furthermore, the refined profiles show that yeast wobble-pairing codons are translated slower than their synonymous Watson–Crick-pairing codons. These results provide evidence that protein synthetic rate can be tuned by codon usage bias.…”
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1113por Raimondi, Célia, Jagla, Bernd, Proux, Caroline, Waxin, Hervé, Gangloff, Serge, Arcangioli, Benoit“…The polar DNA replication of mat1 generates an imprint on the Watson strand. The process by which the imprint is formed and maintained through the cell cycle remains unclear. …”
Publicado 2018
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1114por Saotome, Mika, Saito, Kengo, Yasuda, Takeshi, Ohtomo, Hideaki, Sugiyama, Shusei, Nishimura, Yoshifumi, Kurumizaka, Hitoshi, Kagawa, Wataru“…The ssDNA conformation is close to B-form and appears capable of engaging in Watson-Crick base pairing with the cDNA strand. The second structure revealed a “trapped” conformation of ssDNA between two RAD52 rings. …”
Publicado 2018
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1115por Srivastava, Ruby“…Proton transfer mechanism is a critical phenomenon that is related to the acid–base characteristics of the nucleobases in Watson–Crick base pairs. The energetic and dynamical behavior of the proton can be depicted from these characteristics and their adjustment to the water molecules or the surrounding ions. …”
Publicado 2019
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1116por Herniter, Ira A., Lo, Ryan, Muñoz-Amatriaín, María, Lo, Sassoum, Guo, Yi-Ning, Huynh, Bao-Lam, Lucas, Mitchell, Jia, Zhenyu, Roberts, Philip A., Lonardi, Stefano, Close, Timothy J.“…This study makes use of newly available resources, including mapping populations, a reference genome and additional genome assemblies, and a high-density single nucleotide polymorphism genotyping platform, to map various seed coat pattern traits to three loci, concurrent with the Color Factor (C), Watson (W), and Holstein (H) factors identified previously. …”
Publicado 2019
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1117por Becette, Owen B., Zong, Guanghui, Chen, Bin, Taiwo, Kehinde M., Case, David A., Dayie, T. Kwaku“…Furthermore, the high sensitivity of the (19)F nucleus allows for clear delineation of helical and nonhelical regions as well as GU wobble and Watson-Crick base pairs. Last, the (19)F-(13)C label enables rapid identification of a small-molecule binding pocket within human hepatitis B virus encapsidation signal epsilon (hHBV ε) RNA. …”
Publicado 2020
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1118“…Performance feedback was developed using the IBM Watson conversation program. Twenty office workers used the application for three weeks. …”
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1119“…Replacement of purines by 7‐deazapurines resulted in stable parallel duplexes, thereby confirming Watson–Crick‐type base pairing. When cytosine was facing cytosine, thymine or adenine residues, duplex DNA formed silver‐mediated base pairs in the presence of silver ions. …”
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1120por McKillop, Mollie, South, Brett R, Preininger, Anita, Mason, Mitch, Jackson, Gretchen Purcell“…We describe a platform, Watson Assistant (WA), which has been used to develop conversational agents to deliver COVID-19 related information. …”
Publicado 2021
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