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1781“…Here, it is found that limiting unnecessary stretches of Watson-Crick base pairing, referred to as unnecessary duplexes, can yield exceptionally low kinetic dispersions. …”
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1782por Picchetti, Pierre, Volpi, Stefano, Sancho-Albero, María, Rossetti, Marianna, Dore, Michael D., Trinh, Tuan, Biedermann, Frank, Neri, Martina, Bertucci, Alessandro, Porchetta, Alessandro, Corradini, Roberto, Sleiman, Hanadi, De Cola, Luisa“…In a one-step bottom-up approach, the resulting supramolecular building blocks can be used to prepare responsive organosilica nanoparticles. The supramolecular Watson–Crick–Franklin interactions of the organosilica nanoparticles result in a programmable response to external physical (i.e., temperature) and biological (i.e., DNA and ATP) inputs and thus pave the way for the rational design of multifunctional silica materials with application from drug delivery to theranostics.…”
Publicado 2023
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1783por Sieg, Jacob P, Jolley, Elizabeth A, Huot, Melanie J, Babitzke, Paul, Bevilacqua, Philip C“…The FDBI data was used to determine a set of Watson–Crick free energy nearest neighbor parameters (NNPs), which revealed that Eco80 reduces the stability of three NNPs. …”
Publicado 2023
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1784“…The different behavior of (1D)6PP, (7D)6PP, and (1,7D)6PP indicates that silver(I) binding occurs via the N1 position of the purine derivative, i.e. via the Watson–Crick face. The data show that 6PP is capable of differentiating between cytosine and thymine, which is potentially relevant in the context of detecting single-nucleotide polymorphisms. …”
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1785“…Cleavage of hyper-edited dsRNA occurs within sequences containing multiple IU pairs but not in duplexes that contain either isosteric GU pairs or Watson–Crick base pairs. Here, we describe experiments aimed at further characterizing cleavage of hyper-edited dsRNA. …”
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1786“…The alignment is obtained by maximizing the likelihood of both Watson and Crick strands simultaneously. The resulting alignment of 177 chicken nucleosomal DNA sequences revealed that all 10 distinct dinucleotides are periodic, however, with only two distinct phases and varying intensity. …”
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1787por Meneni, Srinivasa Rao, D'Mello, Rhijuta, Norigian, Gregory, Baker, Gregory, Gao, Lan, Chiarelli, M. Paul, Cho, Bongsup P.“…-AG*N- and -CG*N-) was inversely proportional to the −ΔG° and T(m) values, which highlights the importance of carcinogen/base stacking in duplex stabilization even in the face of disrupted Watson–Crick base pairing in S-conformation. CD studies showed that the extent of the adduct-induced negative ellipticities in the 290–350 nm range is correlated linearly with −ΔG° and T(m), but inversely with the population of B-type conformations. …”
Publicado 2006
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1788“…The kinetics of forming a proper Watson–Crick base pair as well incorporating bases opposite furan, an abasic site analog, have been well characterized for the B Family replicative DNA polymerase from bacteriophage T4. …”
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1789por Yang, Zunyi, Hutter, Daniel, Sheng, Pinpin, Sismour, A. Michael, Benner, Steven A.“…To support efforts to develop a ‘synthetic biology’ based on an artificially expanded genetic information system (AEGIS), we have developed a route to two components of a non-standard nucleobase pair, the pyrimidine analog 6-amino-5-nitro-3-(1′-β-D-2′-deoxyribofuranosyl)-2(1H)-pyridone (dZ) and its Watson–Crick complement, the purine analog 2-amino-8-(1′-β-D-2′-deoxyribofuranosyl)-imidazo[1,2-a]-1,3,5-triazin-4(8H)-one (dP). …”
Publicado 2006
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1790por Rodríguez, Fabián A., Cai, Yuqin, Lin, Chin, Tang, Yijin, Kolbanovskiy, Alexander, Amin, Shantu, Patel, Dinshaw J., Broyde, Suse, Geacintov, Nicholas E.“…In the 5′- ··· CG*GC ··· context, there is no untwisting, but there is significant destabilization of the 5′-flanking Watson–Crick base pair. The minor groove width opens near the lesion in both cases, but more for 5′- ··· CGG*C···. …”
Publicado 2007
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1791“…For Bacillus subtilis RNase P, an isosteric C259-G(74) bp fully and a C258-G(75) bp slightly rescued catalytic proficiency, demonstrating Watson–Crick base pairing to tRNA 3′-CCA but also emphasizing the importance of the base identity of the 5′-proximal G residue (G258). …”
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1792“…G·U wobble base pairs are the most common and highly conserved non-Watson–Crick base pairs in RNA. Previous surface maps imply uniformly negative electrostatic potential at the major groove of G·U wobble base pairs embedded in RNA helices, suitable for entrapment of cationic ligands. …”
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1793por Fish, Daniel J., Horne, M. Todd, Brewood, Greg P., Goodarzi, Jim P., Alemayehu, Saba, Bhandiwad, Ashwini, Searles, Robert P., Benight, Albert S.“…Results also show the relative stability of a tandem mismatch is highly dependent on the identity of the flanking Watson–Crick (w/c) base pairs. Thus, specifying the stability contribution of a tandem mismatch requires consideration of the sequence identity of at least four base pair units (tandem mismatch and flanking w/c base pairs). …”
Publicado 2007
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1794“…One way to predict the secondary structure of an RNA is to identify covarying residues that maintain the pairings (Watson-Crick, Wobble and non-canonical pairings). …”
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1795por Andersen, Felicie F., Knudsen, Bjarne, Oliveira, Cristiano Luis Pinto, Frøhlich, Rikke F., Krüger, Dinna, Bungert, Jörg, Agbandje-McKenna, Mavis, McKenna, Robert, Juul, Sissel, Veigaard, Christopher, Koch, Jørn, Rubinstein, John L., Guldbrandtsen, Bernt, Hede, Marianne S., Karlsson, Göran, Andersen, Anni H., Pedersen, Jan Skov, Knudsen, Birgitta R.“…The inherent properties of DNA as a stable polymer with unique affinity for partner molecules determined by the specific Watson–Crick base pairing makes it an ideal component in self-assembling structures. …”
Publicado 2008
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1796“…In contrast, control substrates with an unstructured loop or a Watson–Crick duplex were unwound equally well by both enzymes. …”
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1797por Manikandan, Jayapal, Aarthi, Joseph Jude, Kumar, Srinivasan Dinesh, Pushparaj, Peter Natesan“…The first miRNAs, lin-4 and let-7, were first discovered in the year 1993 by Ambros, Ruvkun, and co-workers while studying development in Caenorhabditis elegans. miRNAs can play vital functions form C. elegans to higher vertebrates by typical Watson-Crick base pairing to specific mRNAs to regulate the expression of a specific gene. …”
Publicado 2008
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1798por Mitsuoka, Yasunori, Kodama, Tetsuya, Ohnishi, Ryo, Hari, Yoshiyuki, Imanishi, Takeshi, Obika, Satoshi“…Furthermore, mismatched sequence studies showed that BNA(COC) generally improved the sequence selectivity with Watson–Crick base-pairing compared to the corresponding natural DNA and RNA. …”
Publicado 2009
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1799por Zirbel, Craig L., Šponer, Judit E., Šponer, Jiri, Stombaugh, Jesse, Leontis, Neocles B.“…The calculations also show that the most stable phosphate-binding sites occur on the Watson–Crick edge of guanine and the Hoogsteen edge of cytosine. …”
Publicado 2009
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1800“…DNAzymes are catalytic DNA which bind to target RNA by complementary sequence arms on a Watson-Crick basis and cleave RNA at specific sites. …”
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