“…One compact structure was observed to be Mg(2+)-independent, consistent with stabilization by tertiary Watson–Crick base pairing found in the folded Diels–Alderase structure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using this asymmetry in membrane organization near the particle, we identify a new approach for site-selective modification of QDs by specifically functionalizing the QD surface facing the outer lipid leaflet to generate gold nanoparticle–QD assemblies programmed by Watson–Crick base-pairing.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of disease-associated transcripts via Watson–Crick hybridization. ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzymatic degradation of target RNA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Natural DNA's peculiar combination of strong and weak G:C and A:T pairs, the context-dependence of the strengths of those pairs, unimolecular strand folding that competes with desired interstrand hybridization, and non-Watson–Crick interactions available to standard DNA, all contribute to this unpredictability. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Several active variants of the CA motif aptamer lack the ability to form consecutive Watson-Crick base pairs in any register, while others consist of repeats containing only cytidine and adenosine residues, indicating that noncanonical interactions play important roles in its structure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In particular, a prominent hairpin structure (the β-wing) within the RQC winged-helix motif acts as a scalpel to induce the unpairing of a Watson–Crick base pair at the DNA duplex terminus. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The most commonly used approaches are: Smith Peterson, Watson Jones, Hardinge, Moore Southern and Ludloff. …”
Enlace del recurso
Enlace del recurso

“…Hoogsteen (HG) base pairs (bps) provide an alternative pairing geometry to Watson–Crick (WC) bps and can play unique functional roles in duplex DNA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A linear regression was performed using the Enter method to present an unadjusted R (2), standardized coefficients, and standard error, and the Durbin-Watson test was used to assess residual independence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the preface, he diffidently points out that the title (which presents him as the ‘third’ man credited with the co-discovery of the structure of DNA, besides Watson and Crick) was chosen by his publisher, as a reference to the famous 1949 movie no doubt, featuring Orson Welles in his classical role as penicillin racketeer Harry Lime. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Fpg uses an aromatic wedge to open the Watson–Crick base pair and everts the lesion into its active site. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We present an integrative view of all the interaction networks between mRNA, tRNA and rRNA: the intrinsic stability of codon–anticodon duplex, the conformation of the anticodon hairpin, the presence of modified nucleotides, the occurrence of non-Watson–Crick pairs in the codon–anticodon helix and the interactions with bases of rRNA at the A-site decoding site. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Patient-centered activities were categorized using Watson's Caritas Processes and the Relationship-Based Care Delivery System. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…They can fold into reverse-Hoogsteen hairpins and bind to their polypyrimidine target sequence by Watson-Crick bonds forming a three-stranded structure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, the specificity of most current SNM discrimination methods based on the Watson–Crick hybridization is seriously limited by the cross-reactivity of the probe with closely related unintended sequences. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mutations in double-helical regions of RNA may disrupt Watson–Crick (WC) interactions causing structure destabilization or even complete loss of function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results, confirmed also by theoretical calculations, indicate that the preferential binding of the modified units bearing non-ionizable 5-substituents to guanosine in the NNG codons may obey the alternative C-G-like (Watson–Crick) mode, while binding of those bearing aminoalkyl C5-substituents (protonated under physiological conditions) and especially those with a sulfur atom at the C2 position, adopt a zwitterionic form and interact with guanosine via a ‘new wobble’ pattern.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…American Academy of Sleep Medicine criteria were used for sleep scoring if sleep patterns were identified; otherwise, Watson's classification was applied. As remifentanil was periodically administered during the study, its effect on melatonin and sleep was assessed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…For the turbine disk-blade contact system, both of the proposed damage parameters and Smith-Watson-Topper (SWT) model show reasonably acceptable correlations with its field number of flight cycles. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our data show that the universally conserved A2062 and A2503 are capable of forming a non-Watson–Crick base pair that is critical for sensing and transmitting the stalling signal from the exit tunnel back to the peptidyl transferase center of the ribosome. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso