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1861“…Interestingly, this non-Watson–Crick structural feature exists abundantly in promoters of various oncogenes, exons and other genomic locations. …”
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1862“…We treated her using a phase-based approach, and subsequently, added the Watson program to restore normal kinematics. Because of a psychological problem during middle sessions of the physical therapy, we provided psychological education and support. …”
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1863por Li, Lian, Wang, Jiawei, Li, Yachao, Radford, D. Christopher, Yang, Jiyuan, Kopeček, Jindřich“…Here, we report a pretargeting–postassembly approach that exploits the selective Watson–Crick base pairing properties of oligonucleotides and multivalently tethers receptor-prebound antibodies to albumin at the cell surface. …”
Publicado 2019
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1864“…This study was performed to assess articular capsule repair in primary total hip replacement with the anterolateral approach (Watson-Jones incision) and its effect on postoperative dislocation. …”
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1865“…Using external chemicals as the resource and the necessary ribozyme activities, Watson-Crick type replication produces complementary strands burdened by high-rate point mutations (insertions, deletions, substitutions). …”
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1866por Heinz, Marcel, Erlenbach, Nicole, Stelzl, Lukas S, Thierolf, Grace, Kamble, Nilesh R, Sigurdsson, Snorri Th, Prisner, Thomas F, Hummer, Gerhard“…The recently developed [Formula: see text] (G-spin) label, an isoindoline-nitroxide derivative of guanine, can be incorporated non-covalently into DNA and RNA duplexes via Watson-Crick base pairing in an abasic site. We used PELDOR and molecular dynamics (MD) simulations to characterize [Formula: see text] , obtaining excellent agreement between experiments and time traces calculated from MD simulations of RNA and DNA double helices with explicitly modeled [Formula: see text] bound in two abasic sites. …”
Publicado 2020
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1867por Wu, Jian, Zhou, Cuiji, Li, James, Li, Chun, Tao, Xiaorong, Leontis, Neocles B, Zirbel, Craig L, Bisaro, David M, Ding, Biao“…From known RNA 3D structures, we observed that the probability a G/U will form a Watson–Crick (WC) base pair depends on sequence context. …”
Publicado 2020
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1868por Çağlayan, Melike“…Here, we show inefficient ligation of pol β insertion products with mismatched or damaged nucleotides, with the exception of a Watson–Crick-like dGTP insertion opposite T, using BER DNA ligases in vitro. …”
Publicado 2020
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1869por Ban, Željka, Matić, Josipa, Žinić, Biserka, Foller Füchtbauer, Anders, Wilhelmsson, L. Marcus, Piantanida, Ivo“…However, only intramolecularly self-folded qAN1-pyr2 showed strong fluorescence selectivity toward poly U (Watson–Crick complementary to qAN1 nucleobase) and poly A (reverse Hoogsteen complementary to qAN1 nucleobase), while an opposite emission change was observed for non-complementary poly G and poly C. …”
Publicado 2020
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1870“…Surprisingly, C2-modified guanines such as N2-acetylguanine completely disrupt a key Watson–Crick pairing interaction between the ligand and RNA. …”
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1871por Pernod, Ketty, Schaeffer, Laure, Chicher, Johana, Hok, Eveline, Rick, Christian, Geslain, Renaud, Eriani, Gilbert, Westhof, Eric, Ryckelynck, Michael, Martin, Franck“…Only 97 combinations are efficiently accepted and accommodated for translocation and further elongation: 38 combinations involve cognate recognition with Watson-Crick pairs and 59 involve near-cognate recognition pairs with at least one mismatch. …”
Publicado 2020
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1872“…Surge capacity is a concept that has not only been defined as the “ability to respond to a sudden increase in patient care demands” (Hick et al., Disaster Med Public Health Prep. 2008;2:S51-S57) but also to “effectively and rapidly expand capacity” (Watson et al., Milbank Q. 2013;91(1):78-122). This narrative review discusses how Singapore’s largest tertiary hospital has encapsulated the elements of surge capability and transformed a peacetime multi-story carpark into a flu screening area in response to the COVID-19 disease outbreak.…”
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1873por Banerjee, Dipanwita, Tateishi-Karimata, Hisae, Ohyama, Tatsuya, Ghosh, Saptarshi, Endoh, Tamaki, Takahashi, Shuntaro, Sugimoto, Naoki“…The stability of Watson–Crick paired RNA/DNA hybrids is important for designing optimal oligonucleotides for ASO (Antisense Oligonucleotide) and CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)–Cas9 techniques. …”
Publicado 2020
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1874“…Data was analyzed from the IBM Watson Medicaid Marketscan data from 2013 to 2017, a nationally representative dental and medical claims database from 13 deidentified states in the United States. …”
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1875por Marin-Gonzalez, Alberto, Aicart-Ramos, Clara, Marin-Baquero, Mikel, Martín-González, Alejandro, Suomalainen, Maarit, Kannan, Abhilash, Vilhena, J G, Greber, Urs F, Moreno-Herrero, Fernando, Pérez, Rubén“…In this work, we demonstrate that the nucleotide sequence can induce a bend in a canonical Watson-Crick base-paired dsRNA helix. Using all-atom molecular dynamics simulations, we identified a sequence motif consisting of alternating adenines and uracils, or AU-tracts, that strongly bend the RNA double-helix. …”
Publicado 2020
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1876“…The value of R-squared and Durbin-Watson statistic were 0.99 and 1.95 respectively, which showed good model fit. …”
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1877“…Administrative claims data for 3.17 million Medicaid-enrolled children aged 0 to 20 years of age in 13 states in 2016 and 2017 were identified from the IBM Watson MarketScan Medicaid Database. Descriptive and survival analysis reveals most Medicaid enrolled children receive their WCV at an office and hospital, as compared to federally qualified health center, or rural or public health clinic. …”
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1878“…This is consistent with R-loop formation between TS and crRNA releasing NTS from Watson–Crick pairing and facilitating secondary structure formation in it. …”
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1879“…The model verified the IBM Watson and the Microsoft Azure Machine Learning Studio with the algorithms of neural networks, logistic regression, decision jungle, and decision forest, which was the most suitable one. …”
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1880“…By unifying computational conditions, we compared the independent interactions of DNA duplexes, triplexes, and quadruplexes, which led us to evaluate a stability trend among Watson–Crick and Hoogsteen base pairing, stacking, and even ion binding. …”
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