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18201por Nwokoro, Chinedu, Pandya, Hitesh, Turner, Stephen, Eldridge, Sandra, Griffiths, Christopher J, Vulliamy, Tom, Price, David, Sanak, Marek, Holloway, John W, Brugha, Rossa, Koh, Lee, Dickson, Iain, Rutterford, Clare, Grigg, Jonathan“…METHODS: We did this multicentre, parallel-group, randomised, placebo-controlled trial between Oct 1, 2010, and Dec 20, 2013, at 21 primary care sites and 41 secondary care sites in England and Scotland. Children aged 10 months to 5 years with two or more wheeze episodes were allocated to either a 5/5 or 5/x+x/x ALOX5 promoter genotype stratum, then randomly assigned (1:1) via a permuted block schedule (size ten), to receive intermittent montelukast or placebo given by parents at each wheeze episode over a 12 month period. …”
Publicado 2014
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18202por Sheard, Laura, O’Hara, Jane, Armitage, Gerry, Wright, John, Cocks, Kim, McEachan, Rosemary, Watt, Ian, Lawton, Rebecca“…The trial will take place across 32 hospital wards in three NHS Hospital Trusts in the North of England. The PRASE intervention comprises two tools: (1) a 44-item questionnaire which asks patients about safety concerns and issues; and (2) a proforma for patients to report (a) any specific patient safety incidents they have been involved in or witnessed and (b) any positive experiences. …”
Publicado 2014
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18203por Broderick, Claire, Nadjm, Behzad, Smith, Valerie, Blaze, Marie, Checkley, Anna, Chiodini, Peter L, Whitty, Christopher J M“…Setting National surveillance data from the UK Public Health England Malaria Reference Laboratory, data from the International Passenger Survey, and international climactic data. …”
Publicado 2015
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18204“…Most of the randomized evidence came from Australia, with nonrandomized comparative evidence available from Australia, Canada, England, Sweden and the US. None of the comparative evidence isolated the effect of integrated funding; instead, studies assessed the effects of ‘integrated financing plus integrated care’ (i.e. …”
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18205por Schembari, Anna, de Hoogh, Kees, Pedersen, Marie, Dadvand, Payam, Martinez, David, Hoek, Gerard, Petherick, Emily S., Wright, John, Nieuwenhuijsen, Mark J.“…METHOD: Pregnant women were recruited between 2007 and 2010 for the Born in Bradford cohort study, in England. Exposures to particulate matter (≤ 10 μm, PM(10); ≤ 2.5 μm, PM(2.5)), PM(2.5) absorbance, and nitrogen oxides (NO(x), NO(2)) were estimated using land-use regressions models. …”
Publicado 2015
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18206por Wright-Hughes, Alexandra, Graham, Elizabeth, Farrin, Amanda, Collinson, Michelle, Boston, Paula, Eisler, Ivan, Fortune, Sarah, Green, Jonathan, House, Allan, Owens, David, Simic, Mima, Tubeuf, Sandy, Nixon, Jane, McCabe, Christopher, Kerfoot, Michael, Cottrell, David“…Both therapeutic interventions were delivered within the National Health Service (NHS) Child and Adolescent Mental Health Services (CAMHS) in England. Participants and therapists were, of necessity, aware of treatment allocation, but the researchers were blind to the allocations to allow unbiased collection of follow-up data. …”
Publicado 2015
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18207por Wu, Raymond, Woodford, Hannah, Capp, Anne, Hunter, Perry, Cowin, Gary, Tai, Keen-Hun, Nguyen, Paul L., Chong, Peter, Martin, Jarad“…TRIAL REGISTRATION: ClincialTrials.gov identifier NCT01418040. Hunter New England Human Research Ethics Committee (HNEHREC) reference number 12/08/15/4.02…”
Publicado 2015
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18208por Davies, Anna K., McGale, Nadine, Humphries, Steve E., Hirani, Shashivadan P., Beaney, Katherine E., Bappa, Dauda A. S., McCabe, John G., Newman, Stanton P.“…METHODS/DESIGN: Participants will be adults aged 25–74 years registered with general practices in the East of England, diagnosed with type 2 diabetes, with no history of heart disease, and with a glycated haemoglobin level of ≥6.45 % (47 mmol/mol). …”
Publicado 2015
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18209por Leslie, Wilma S., Ford, Ian, Sattar, Naveed, Hollingsworth, Kieren G., Adamson, Ashley, Sniehotta, Falko F., McCombie, Louise, Brosnahan, Naomi, Ross, Hazel, Mathers, John C., Peters, Carl, Thom, George, Barnes, Alison, Kean, Sharon, McIlvenna, Yvonne, Rodrigues, Angela, Rehackova, Lucia, Zhyzhneuskaya, Sviatlana, Taylor, Roy, Lean, Mike E. J.“…METHODS/DESIGN: Cluster-randomised design with GP practice as the unit of randomisation: 280 participants from around 30 practices in Scotland and England will be allocated either to continue usual guideline-based care or to add the Counterweight-Plus weight management programme, which includes primary care nurse or dietitian delivery of 12-20weeks low calorie diet replacement, food reintroduction, and long-term weight loss maintenance. …”
Publicado 2016
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18210por Turner-Stokes, Lynne, Williams, Heather, Bill, Alan, Bassett, Paul, Sephton, Keith“…SETTING: All 62 specialist (levels 1 and 2) rehabilitation services in England. PARTICIPANTS: Working-aged adults (16–65 years) with complex neurological disability. …”
Publicado 2016
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18211por Richmond, Helen, Hall, Amanda M., Hansen, Zara, Williamson, Esther, Davies, David, Lamb, Sarah E.“…Participants were recruited from 8 National Health Service departments in England and allocated by a computer generated randomisation list to receive iBeST (n = 16) or a face-to-face workshop (n = 19). …”
Publicado 2016
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18212“…Setting 1243 general practices contributing data to the QResearch database in England. Participants 469 688 people with type 2 diabetes aged 25-84 years between 1 April 2007 and 31 January 2015. …”
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18213por Kapatai, Georgia, Sheppard, Carmen L., Al-Shahib, Ali, Litt, David J., Underwood, Anthony P., Harrison, Timothy G., Fry, Norman K.“…This information was used to design a decision-tree style algorithm within the PneumoCaT bioinformatics tool to predict to serotype level for 89/94 (92 + 2 molecular types/subtypes) from WGS data and to serogroup level for serogroups 24 and 32, which currently comprise 2.1% of UK referred, invasive isolates submitted to the National Reference Laboratory (NRL), Public Health England (June 2014–July 2015). PneumoCaT was evaluated with an internal validation set of 2065 UK isolates covering 72/92 serotypes, including 19 non-typeable isolates and an external validation set of 2964 isolates from Thailand (n = 2,531), USA (n = 181) and Iceland (n = 252). …”
Publicado 2016
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18214“…The objective of this article is to describe how equity and equality was addressed in PA policies in four EU member states (Denmark, Finland, Romania and England), who were partners in the REPOPA project (www.repopa.eu, EC/FP7/Health Research/GA 281532). …”
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18215por Godino, Job G., van Sluijs, Esther M. F., Marteau, Theresa M., Sutton, Stephen, Sharp, Stephen J., Griffin, Simon J.“…METHODS AND FINDINGS: We recruited 569 healthy middle-aged adults from the Fenland Study, an ongoing population-based, observational study in the east of England (Cambridgeshire, UK). We used a computer-generated random list to assign participants in blocks of six to receive either standard lifestyle advice alone (control group, n = 190) or in combination with a genetic (n = 189) or a phenotypic (n = 190) risk estimate for type 2 diabetes (intervention groups). …”
Publicado 2016
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18216por Lorencatto, Fabiana, Gould, Natalie J., McIntyre, Stephen A., During, Camilla, Bird, Jon, Walwyn, Rebecca, Cicero, Robert, Glidewell, Liz, Hartley, Suzanne, Stanworth, Simon J., Foy, Robbie, Grimshaw, Jeremy M., Michie, Susan, Francis, Jill J.“…BACKGROUND: In England, NHS Blood and Transplant conducts national audits of transfusion and provides feedback to hospitals to promote evidence-based practice. …”
Publicado 2016
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18217por Pascale, Melanie, Murray, Nikki, Bachmann, Max, Barton, Garry, Clark, Allan, Howe, Amanda, Greaves, Colin, Sampson, Mike“…METHODS: NDPS identifies people at highest risk of T2DM on the databases of 135 general practices in the East of England for further screening with ab fasting plasma glucose and glycosylated haemoglobin [HbA1c]. …”
Publicado 2017
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18218por Higginson, Irene J., Reilly, Charles C., Bajwah, Sabrina, Maddocks, Matthew, Costantini, Massimo, Gao, Wei“…METHODS: This population-based observational study linked death registration data for people in England dying from chronic obstructive pulmonary disease (COPD) or interstitial pulmonary diseases (IPD). …”
Publicado 2017
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18219por Wang, Rui, Chen, Zhaoyu, Fu, Yongmei, Wei, Xiaobo, Liao, Jinchi, Liu, Xu, He, Bingjun, Xu, Yunqi, Zou, Jing, Yang, Xiaoyan, Weng, Ruihui, Tan, Sheng, McElroy, Christopher, Jin, Kunlin, Wang, Qing“…The severity of dementia was determined based on the Schwab and England Activities of Daily Living (ADL) Scale, the Mini-mental State Examination (MMSE), the Global Deterioration Scale (GDS), the Lawton Instrumental ADL (IADL) Scale, and the Hachinski Ischemia Scale (Hachinski). …”
Publicado 2017
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18220por Lloyd, Jenny, Creanor, Siobhan, Price, Lisa, Abraham, Charles, Dean, Sarah, Green, Colin, Hillsdon, Melvyn, Pearson, Virginia, Taylor, Rod S., Tomlinson, Richard, Logan, Stuart, Hurst, Alison, Ryan, Emma, Daurge, Wendy, Wyatt, Katrina“…METHODS: Schools were recruited from across the South West of England and allocated 1:1 to either intervention (HeLP) or control (usual practice) stratified by the proportion of children eligible for free school meals (FSM, <19%, ≥19%) and school size (one Year 5 class, >1 Year 5 class). …”
Publicado 2017
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