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18581por Parry, M. G., Cowling, T. E., Sujenthiran, A., Nossiter, J., Berry, B., Cathcart, P., Aggarwal, A., Payne, H., van der Meulen, J., Clarke, N. W., Gnanapragasam, V. J.“…We investigated radical treatment rates according to CPG in men diagnosed with non-metastatic prostate cancer in England between 2014 and 2017. METHODS: Patients diagnosed with non-metastatic prostate cancer were identified from the National Prostate Cancer Audit database. …”
Publicado 2020
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18582por Gooding, Patricia A., Pratt, Daniel, Awenat, Yvonne, Drake, Richard, Elliott, Rachel, Emsley, Richard, Huggett, Charlotte, Jones, Steven, Kapur, Navneet, Lobban, Fiona, Peters, Sarah, Haddock, Gillian“…Recruitment will be from NHS mental health services in the North West of England, UK. Participants must be 18 or over; be under the care of mental health services; have mental health problems which meet ICD-10 non-affective psychosis criteria; and have experienced self-reported suicidal thoughts, plans, and/or attempts in the 3 months prior to recruitment. …”
Publicado 2020
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18583por Hanney, Stephen R., Kanya, Lucy, Pokhrel, Subhash, Jones, Teresa H., Boaz, Annette“…Countries effectively implementing strategies include England, Ireland and Rwanda, whereas West Africa experienced effective partnerships. …”
Publicado 2020
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18584por Lawson, Andrew, Naylor, Justine, Buchbinder, Rachelle, Ivers, Rebecca, Balogh, Zsolt, Smith, Paul, Mittal, Rajat, Xuan, Wei, Howard, Kirsten, Vafa, Arezoo, Yates, Piers, Rieger, Bertram, Smith, Geoff, Elkinson, Ilia, Kim, Woosung, Sungaran, Jai, Latendresse, Kim, Wong, James, Viswanathan, Sameer, Landale, Keith, Drobetz, Herwig, Tran, Phong, Page, Richard, Hau, Raphael, Mulford, Jonathan, Incoll, Ian, Kale, Michael, Schick, Bernard, Higgs, Andrew, Oppy, Andrew, Perriman, Diana, Harris, Ian“…TRIAL REGISTRATION: CROSSFIRE was approved by The Hunter New England Human Research Ethics Committee (HNEHREC Reference No: 16/02/17/3.04). …”
Publicado 2020
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18585por Lemanska, Agnieszka, Byford, Rachel C., Cruickshank, Clare, Dearnaley, David P., Ferreira, Filipa, Griffin, Clare, Hall, Emma, Hinton, William, de Lusignan, Simon, Sherlock, Julian, Faithfull, Sara“…RESULTS: Primary care records were extracted for 106 out of 2811 CHHiP participants recruited from sites in England (median age 70, range 44 to 82). Complementary information included longitudinal body mass index, blood pressure and cholesterol, as well as baseline smoking and alcohol usage but was limited by the considerable missing data. …”
Publicado 2020
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18586por Byrne, Jo L., Dallosso, Helen M., Rogers, Stephen, Gray, Laura J., Waheed, Ghazala, Patel, Prashanth, Gupta, Pankaj, Doherty, Yvonne, Davies, Melanie J., Khunti, Kamlesh“…METHODS: Pragmatic randomised controlled trial recruited between May 2016 and March 2017 from primary care practices, England. Participants (n = 212) prescribed statins for primary prevention of cardiovascular disease with total cholesterol level ≥ 5 mmol/l were randomised: 105 to the intervention group and 107 to the control group, stratified by age and sex. …”
Publicado 2020
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18587por Proctor, Joanna, Naughton, Felix, Sloan, Melanie, Hopewell, Sarah, Brimicombe, James, Prevost, A Toby, Wilson, Edward C F, Coleman, Tim, Sutton, Stephen“…BACKGROUND: The prevalence of smoking is declining; however, it continues to be a major public health burden. In England, primary care is the health setting that provides smoking cessation support to most smokers. …”
Publicado 2020
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18588por Hoare, Erin, Werneck, Andre O., Stubbs, Brendon, Firth, Joseph, Collins, Sam, Corder, Kirsten, van Sluijs, Esther M. F.“…RESULTS: A total of 9369 participants were included in waves 4 and 6 of the Millennium Cohort Study, including 4665 (48.1%) girls and 6014 participants (81.9%) who were born in England. Adolescents who self-reported mental health problems at age 14 years only were less likely to have at least 9 hours of sleep (odds ratio [OR], 0.39; 95% CI, 0.34-0.45) and to consume fruit (OR, 0.55; 95% CI, 0.46-0.65) and vegetables (OR, 0.66; 95% CI, 0.52-0.83) reported greater use of social media (b = 0.62; 95% CI, 0.49-0.75) compared with individuals who did not have mental health problems at both time points. …”
Publicado 2020
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18589por Nicholson, Brian D, Aveyard, Paul, Price, Sarah J, Hobbs, FD Richard, Koshiaris, Constantinos, Hamilton, Willie“…SETTING: Clinical Practice Research Datalink electronic health records data linked to the National Cancer Registration and Analysis Service in primary care, England. PARTICIPANTS: 63 973 adults (≥18 years) with a code for unexpected WL from 1 January 2000 to 31 December 2012. …”
Publicado 2020
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18590por Bray, Lucy, Sharpe, Ashley, Gichuru, Phillip, Fortune, Peter-Marc, Blake, Lucy, Appleton, Victoria“…Participants were children aged between 8 and 14 years and their parents who attended a hospital for a planned clinical procedure at a children’s hospital in North West England. Children and their parents completed self-report measures (perceived knowledge, procedural anxiety, procedural satisfaction, and procedural involvement) at baseline, preprocedure, and postprocedure. …”
Publicado 2020
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18591por Fisher, Harriet, Harding, Sarah, Bell, Sarah, Copeland, Lauren, Evans, Rhiannon, Powell, Jillian, Araya, Ricardo, Campbell, Rona, Ford, Tamsin, Gunnell, David, Murphy, Simon, Kidger, Judi“…BACKGROUND: Improving children and young people’s provision for mental health is a current health priority in England. Secondary school teachers have worse mental health outcomes than the general working population, which the Wellbeing in Secondary Education (WISE) cluster randomised controlled trial aimed to improve. …”
Publicado 2020
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18592por Adams, Catherine, Gaile, Jacqueline, Roddam, Hazel, Baxendale, Janet, Clitheroe, Laura, Emsley, Richard“…METHODS: A questionnaire was distributed to paediatric speech and language therapists in England. Survey questions addressed number of eligible children, routine intervention provision and trial recruitment factors. …”
Publicado 2020
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18593por Col, Nananda, Hull, Stephen, Springmann, Vicky, Ngo, Long, Merritt, Ernie, Gold, Susan, Sprintz, Michael, Genova, Noel, Nesin, Noah, Tierman, Brenda, Sanfilippo, Frank, Entel, Richard, Pbert, Lori“…TRIAL REGISTRATION: This study was approved by the University of New England Independent Review Board for the Protection of Human Subjects in Research (012616–019) and was registered with ClinicalTrials.gov (protocol ID: NCT03425266) prior to enrollment. …”
Publicado 2020
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18594por Nightingale, J., Fowler-Davis, S., Grafton, K., Kelly, S., Langham, C., Lewis, R., Bianco, B., Harrop, D.“…BACKGROUND: Developing research capability and capacity within the healthcare professions is a challenge throughout diverse international settings. Within England, the National Institute for Health Research aimed to address these challenges through the Integrated Clinical Academic (ICA) research careers escalator for nurses, midwives and allied health professionals. …”
Publicado 2020
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18595por Clift, Ash K, Coupland, Carol A C, Keogh, Ruth H, Diaz-Ordaz, Karla, Williamson, Elizabeth, Harrison, Ewen M, Hayward, Andrew, Hemingway, Harry, Horby, Peter, Mehta, Nisha, Benger, Jonathan, Khunti, Kamlesh, Spiegelhalter, David, Sheikh, Aziz, Valabhji, Jonathan, Lyons, Ronan A, Robson, John, Semple, Malcolm G, Kee, Frank, Johnson, Peter, Jebb, Susan, Williams, Tony, Hippisley-Cox, Julia“…SETTING AND PARTICIPANTS: QResearch database, comprising 1205 general practices in England with linkage to covid-19 test results, Hospital Episode Statistics, and death registry data. 6.08 million adults aged 19-100 years were included in the derivation dataset and 2.17 million in the validation dataset. …”
Publicado 2020
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18596por Buckingham, Sarah Ann, Morrissey, Karyn, Williams, Andrew James, Price, Lisa, Harrison, John“…Police officers and staff (n = 180) were recruited from two police forces in South West England. Participants used the technology for 12 weeks (an ‘individual’ then ‘social’ phase) followed by 5 months of optional use. …”
Publicado 2020
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18597por Mulchandani, Ranya, Jones, Hayley E, Taylor-Phillips, Sian, Shute, Justin, Perry, Keith, Jamarani, Shabnam, Brooks, Tim, Charlett, Andre, Hickman, Matthew, Oliver, Isabel, Kaptoge, Stephen, Danesh, John, Di Angelantonio, Emanuele, Ades, Anthony E, Wyllie, David H, Armitage, Jane, Borrow, Ray, Boyes, John, Cullen, Donna, Hormis, Anil, Linley, Ezra, Mehenny, Susan, Miflin, Gail, Moore, Carmel, Moore, Philippa, Reckless, Ian, Roberts, David J, Sambrook, Jennifer, Todd, Neil“…PARTICIPANTS: 2847 key workers (healthcare staff, fire and rescue officers, and police officers) in England in June 2020 (268 with a previous polymerase chain reaction (PCR) positive result (median 63 days previously), 2579 with unknown previous infection status); and 1995 pre-pandemic blood donors. …”
Publicado 2020
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18598por Miller, Jessica E., Goldacre, Raphael, Moore, Hannah C., Zeltzer, Justin, Knight, Marian, Morris, Carole, Nowell, Sian, Wood, Rachael, Carter, Kim W., Fathima, Parveen, de Klerk, Nicholas, Strunk, Tobias, Li, Jiong, Nassar, Natasha, Pedersen, Lars H., Burgner, David P.“…METHODS AND FINDINGS: We conducted a multicountry population-based cohort study of all recorded singleton live births from January 1, 1996 to December 31, 2015 using record-linked birth and hospitalisation data from Denmark, Scotland, England, and Australia (New South Wales and Western Australia). …”
Publicado 2020
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18599por Smith, Kirsten Ailsa, Bradbury, Katherine, Essery, Rosie, Pollet, Sebastien, Mowbray, Fiona, Slodkowska-Barabasz, Joanna, Denison-Day, James, Hayter, Victoria, Kelly, Jo, Somerville, Jane, Zhang, Jin, Grey, Elisabeth, Western, Max, Ferrey, Anne E, Krusche, Adele, Stuart, Beth, Mutrie, Nanette, Robinson, Sian, Yao, Guiqing Lily, Griffiths, Gareth, Robinson, Louise, Rossor, Martin, Gallacher, John, Griffin, Simon, Kendrick, Tony, Rathod, Shanaya, Gudgin, Bernard, Phillips, Rosemary, Stokes, Tom, Niven, John, Little, Paul, Yardley, Lucy“…We will be conducting the intervention with 2 populations recruited through GP practices (family practices) in England from 2018 to 2019: older adults with signs of cognitive decline and older adults without any cognitive decline. …”
Publicado 2020
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18600por Gupta, Rishi K, Harrison, Ewen M, Ho, Antonia, Docherty, Annemarie B, Knight, Stephen R, van Smeden, Maarten, Abubakar, Ibrahim, Lipman, Marc, Quartagno, Matteo, Pius, Riinu, Buchan, Iain, Carson, Gail, Drake, Thomas M, Dunning, Jake, Fairfield, Cameron J, Gamble, Carrol, Green, Christopher A, Halpin, Sophie, Hardwick, Hayley E, Holden, Karl A, Horby, Peter W, Jackson, Clare, Mclean, Kenneth A, Merson, Laura, Nguyen-Van-Tam, Jonathan S, Norman, Lisa, Olliaro, Piero L, Pritchard, Mark G, Russell, Clark D, Scott-Brown, James, Shaw, Catherine A, Sheikh, Aziz, Solomon, Tom, Sudlow, Cathie, Swann, Olivia V, Turtle, Lance, Openshaw, Peter J M, Baillie, J Kenneth, Semple, Malcolm G, Noursadeghi, Mahdad“…METHODS: We developed and validated a multivariable logistic regression model for in-hospital clinical deterioration (defined as any requirement of ventilatory support or critical care, or death) among consecutively hospitalised adults with highly suspected or confirmed COVID-19 who were prospectively recruited to the International Severe Acute Respiratory and Emerging Infections Consortium Coronavirus Clinical Characterisation Consortium (ISARIC4C) study across 260 hospitals in England, Scotland, and Wales. Candidate predictors that were specified a priori were considered for inclusion in the model on the basis of previous prognostic scores and emerging literature describing routinely measured biomarkers associated with COVID-19 prognosis. …”
Publicado 2021
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