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  1. 18861
    “…Using advertisements on a national health portal and through its mailing list, we recruited 3070 participants aged 18 or over, resident in England, and willing to give their email address and access a fully automated Web-based intervention. …”
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    Effectiveness of a Web-Based Cognitive-Behavioral Tool to Improve Mental Well-Being in the General Population: Randomized Controlled Trial
  2. 18862
    “…We used data from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3) to explore associations between health and sexual lifestyles in Britain (England, Scotland, and Wales). METHODS: Men and women aged 16–74 years who were resident in households in Britain were interviewed between Sept 6, 2010, and Aug 31, 2012. …”
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    Associations between health and sexual lifestyles in Britain: findings from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)
  3. 18863
    “…We undertook the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3) after implementation of national sexual health strategies, and describe the epidemiology of four STIs in Britain (England, Scotland, and Wales) and the uptake of interventions. …”
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    Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal)
  4. 18864
    “…BACKGROUND: The National Reporting and Learning System (NRLS) collects reports about patient safety incidents in England. Government regulators use NRLS data to assess the safety of hospitals. …”
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    Can Patient Safety Incident Reports Be Used to Compare Hospital Safety? Results from a Quantitative Analysis of the English National Reporting and Learning System Data
  5. 18865
    “…In the past, human disease outbreaks in the northeastern U.S. have occurred intermittently with no apparent pattern; however, during the last decade we have witnessed recurring annual emergence where EEE virus activity had been historically rare, and expansion into northern New England where the virus had been previously unknown. …”
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    Dynamics of Vector-Host Interactions in Avian Communities in Four Eastern Equine Encephalitis Virus Foci in the Northeastern U.S.
  6. 18866
    “…METHODS AND FINDINGS: This study was conducted in the Public Health England EVD diagnostic laboratory in Port Loko, Sierra Leone, using residual diagnostic specimens remaining after clinical testing. …”
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    Performance of the GeneXpert Ebola Assay for Diagnosis of Ebola Virus Disease in Sierra Leone: A Field Evaluation Study
  7. 18867
    por Croudace, Tim, Brazier, John, Gutacker, Nils, Street, Andrew, Robotham, Dan, Waterman, Samantha, Rose, Diana, Satkunanathan, Safarina, Wykes, Til, Nasr, Nasrin, Enderby, Pamela, Carlton, Jill, Rowen, Donna, Elliott, Jackie, Brazier, John, Stevens, Katherine, Basarir, Hasan, Labeit, Alex, Murphy, Mairead, Hollinghurst, Sandra, Salisbury, Chris, Marley, Dominic, Wilson, James, Barrat, Amy, Roy, Bibhas, Rombach, Ines, Burke, Órlaith, Jenkinson, Crispin, Gray, Alastair, Rivero-Arias, Oliver, Porter, Ian, Gangannagaripalli, Jaheeda, Bramwell, Charlotte, Valderas, Jose M., Holch, Patricia, Davidson, Susan, Routledge, Jacki, Henry, Ann, Franks, Kevin, Gilbert, Alex, Absolom, Kate, Velikova, Galina, Porter, Ian, Valderas, Jose M., Boehnke, Jan R., Trigg, Andrew, Howells, Ruth, Singh, Jeshika, Pokhrel, Subhash, Longworth, Louise, Potter, Caroline, Hunter, Cheryl, Kelly, Laura, Gibbons, Elizabeth, Forder, Julian, Coulter, Angela, Fitzpatrick, Ray, Peters, Michele
    Publicado 2016
    “…Analysis of Health Survey for England dataset Jeshika Singh, Subhash Pokhrel, Louise Longworth O14 Where patients and policy meet: exploring individual-level use of the Long-Term Conditions Questionnaire (LTCQ) Caroline Potter, Cheryl Hunter, Laura Kelly, Elizabeth Gibbons, Julian Forder, Angela Coulter, Ray Fitzpatrick, Michele Peters…”
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    Proceedings of Patient Reported Outcome Measure’s (PROMs) Conference Sheffield 2016: advances in patient reported outcomes research: Sheffield, UK. 9th June 2016
  8. 18868
    “…METHODS: We conducted a linked electronic health record cohort study of 70 206 individuals with initial record of diagnosis of AF in primary (n=29 568) or secondary care (n=40 638) in England (1998–2010). We defined stroke risk according to the CHA(2)DS(2)-VASc score, and followed individuals over a median 2.2 years for 7005 ischaemic strokes (IS) and for 906 haemorrhagic strokes (HS). …”
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    Net clinical benefit of warfarin in individuals with atrial fibrillation across stroke risk and across primary and secondary care
  9. 18869
    por Kemp, H. I., Bantel, C., Gordon, F., Brett, S. J., Laycock, H. C., Bampoe, Sohail, Bantel, Carsten, Gooneratne, Mevan, Highton, David, Hopkins, Phil, Johnston, Carolyn, Odor, Peter, Kemp, Harriet, Laycock, Helen, Martin, Daniel, O'Carroll, James, Phillips, Sioned, Visram, Anil, Siddique, Omar, Burdett, Edward, May, Rosie, Renwick, Sonia, Gray, Martin, Spiro, Michael, Luoma, Val, Chamarette, Holly, Young, Trudy, Wagstaff, Duncan, Lewith, Henry, Gowrie, Shan, Bramall, Jon, Collison, Lucy, Mansell, Josephine, Hamilton, Kevin, Leigh, Alexander, Dawson, Jeremy, Morkane, Clare, Balla, Paul, Shukla, Bhavin, Rublotta, Francesca, Cousins, Jonathan, Magee, David, Cashell, Catherine, Kooner, Gurleen, Arnold, Glenn, Garnelo Ray, Vanessa, Clancy, Olivia, Whitehead, Nicole, Kooner, Gurleen, Handy, Jonathan, Vizcaychipi, Marcella, Edwards, Zara, Davis‐Hall, Melanie, Addy, Melissa, Jhanji, Shaman, Wigmore, Tim, Christie, Linsey, Sidon, Lauren, Grover, Munita, Panagoda, Prasan, Howells, Lara, Cartwright, Charles, Doyle, Richard, Griffith, Megan, Casely, Emma, Holdgate, Andrew, Rich, Stephanie, Henriksson, Maria, Jaggar, Sian, Tatham, Kate, Kadry, Mirian, Finlay, Claire, Pandit, Ajoy, Mehdipour, Savviz, Ong, Cheng, Bidd, Heena, Ramessur, Suneil, Anwar, Sibtain, Blunt, Nadia, Williams, Hannah, Tosini, Chiara, Parini, Alessandra, Kumar, Ravi, Ferrier, Victoria, Gupta, Aman, Canavan, Aoife, Dickinson, Matt, Carey, Ben, Somasundaram, Karthik, De Silva, Samanthi, Moghulm, Arif, Dua, Kanika, McHugh, Barry, Chapman, Rachel, Peck, Marcus, Sangam, Amy, Al‐Sahaf, Hadi, Gowripalann, Tharumalingam, Kunnumpurath, Sreekumar, Mottaleb, Ramy, Fletcher, Kate, Bhagwat, Milind, Eeles, Alex, Hunningher, Annie, Nesbit, Finn, Turton, Danny, Barringer, Chris, Dannatt, Peter, Shenoy, Venkat, Keogh, Peter, Krishnachetty, Bobby, Mendes, Fiona, Ferns, Janis, Kennedy, Charles, Sandru, Roxana, Husain, Naush, Holler, Liesel, Barnes, Lucy, Thorburn, Patrick, Shippam, William, Lee, Sindy, Mahgoub, Sara
    Publicado 2017
    “…This observational service evaluation considered all pain and analgesia‐related entries in patients’ records over a 24‐h period, in 45 adult intensive care units (ICUs) in London and the South‐East of England. Data were collected from 750 patients, reflecting the practice of 362 physicians. …”
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    Pain Assessment in INTensive care (PAINT): an observational study of physician‐documented pain assessment in 45 intensive care units in the United Kingdom
  10. 18870
    “…METHODS: In this non-blinded, parallel-group, randomised controlled trial, we recruited participants who were aged 18 years or older and had body-mass index (BMI) of 28 kg/m(2) or higher from 23 primary care practices in England. Participants were randomly assigned (2:5:5) to brief advice and self-help materials, a weight-management programme (Weight Watchers) for 12 weeks, or the same weight-management programme for 52 weeks. …”
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    Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial
  11. 18871
    por Scott, Anna Mae, Wale, Janet L.
    Publicado 2017
    “…Respondents from the following countries reported involvement in HTA processes: Canada, England, Scotland, and Wales, The Netherlands, Australia, Taiwan. …”
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    Patient advocate perspectives on involvement in HTA: an international snapshot
  12. 18872
    por Staley, Kristina, Doherty, Caroline
    Publicado 2016
    “…ABSTRACT: Background Health technology appraisal involves reviewing clinical and economic data to inform guidance on the use of technology. In England this task is carried out by appraisal committees within the National Institute for Health and Care Excellence (NICE). …”
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    It’s not evidence, it’s insight: bringing patients’ perspectives into health technology appraisal at NICE
  13. 18873
    “…Setting Routinely collected data from 1457 general practices in England contributing to the QResearch database: 1094 were used to develop the scores and a separate set of 363 were used to validate the scores. …”
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    Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study
  14. 18874
    “…FUNDING: Arthritis Research UK, the National Institute for Health Research Biomedical Research Centre, and the Royal College of Surgeons (England).…”
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    Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial
  15. 18875
    “…Pedigrees originated in Italy, Brazil, Canada, England, Iran, and Japan. Interestingly, we identified 15 ALS5/SPG11/ KIAA1840 mutations in 12 families (two sequence variants were never reported before, p.Gln198* and p.Pro2212fs*5). …”
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    ALS5/SPG11/ KIAA1840 mutations cause autosomal recessive axonal Charcot–Marie–Tooth disease
  16. 18876
    “…METHODS: The study employed a cluster randomised controlled trial design involving children aged 3 to 6 years, attending ten childcare services in the Hunter New England region of New South Wales, Australia. Five services were randomised to receive the intervention and five to a control condition. …”
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    Impact of scheduling multiple outdoor free-play periods in childcare on child moderate-to-vigorous physical activity: a cluster randomised trial
  17. 18877
    “…This paper summarises the company submission (CS), the ERG report and the NICE guidance produced by the appraisal committee (AC) for the use of ticagrelor in England and Wales. The ERG critically reviewed the clinical- and cost-effectiveness evidence in the CS. …”
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    Ticagrelor for Secondary Prevention of Atherothrombotic Events After Myocardial Infarction: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
  18. 18878
    “…Adults aged 18 or over with a diagnosis of type 2 diabetes and registered with the 21 participating general practices (primary care) in England, UK, were approached. People who were unable to provide informed consent or to use the intervention, terminally ill, or currently participating in a trial of an alternative self-management intervention, were excluded. …”
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    Cost-Effectiveness of Facilitated Access to a Self-Management Website, Compared to Usual Care, for Patients With Type 2 Diabetes (HeLP-Diabetes): Randomized Controlled Trial
  19. 18879
    “…METHODS AND FINDINGS: We used longitudinal data from linked electronic health records of 4.6 million patients aged 18–100 years from 389 practices across England between 1985 to 2015. The population was divided into a derivation cohort (80%, 3.75 million patients from 300 general practices) and a validation cohort (20%, 0.88 million patients from 89 general practices) from geographically distinct regions with different risk levels. …”
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    Predicting the risk of emergency admission with machine learning: Development and validation using linked electronic health records
  20. 18880
    “…METHODS: In a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial, patients aged 55–73 years who were identified during colonoscopy as being at high risk in the English Bowel Cancer Screening Programme (BCSP; ≥3 adenomas if at least one was ≥10 mm in diameter or ≥5 adenomas if these were <10 mm in diameter) were recruited from 53 BCSP endoscopy units in England, UK. Patients were randomly allocated (1:1:1:1) using a secure web-based server to receive 2 g EPA-free fatty acid (FFA) per day (either as the FFA or triglyceride), 300 mg aspirin per day, both treatments in combination, or placebo for 12 months using random permuted blocks of randomly varying size, and stratified by BCSP site. …”
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    Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial
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