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  1. 1961
    “…In all these chronic diseases protein, lipid or nucleic acid modifications are involved, including cross-linked and non-degradable aggregates, such as advanced glycation end products (AGEs). Formation of endogenous or uptake of dietary AGEs can lead to further protein modifications and activation of several inflammatory signaling pathways. …”
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  2. 1962
  3. 1963
    “…Little is known about the end-of-life (EOL) experience of patients with rare cancers (PRC) or their caregivers. …”
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  4. 1964
  5. 1965
    “…CONCLUSION: This is the first reported case of end stage renal failure in a patient who is taking vemurafenib. …”
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  6. 1966
    “…Cytoplasmic dynein powers intracellular movement of cargo toward the microtubule minus end. The first step in a variety of dynein transport events is the targeting of dynein to the dynamic microtubule plus end, but the molecular mechanism underlying this spatial regulation is not understood. …”
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  7. 1967
  8. 1968
    “…A literature review focused on end-of-life (EOL) case management identified 17 research articles, with content analysis revealing two themes: (a) seeking to determine or establish the value of EOL case management and (b) identifying ways to improve EOL case management. …”
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  9. 1969
  10. 1970
  11. 1971
  12. 1972
    “…Molecular imaging and biophysical analysis suggest that transport is powered by dynein pulling on minus ends of severed microtubules. NuMA and dynein/dynactin are specifically enriched at new minus ends within seconds, reanchoring minus ends to the spindle and delivering them to poles. …”
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  13. 1973
    “…The end-Ordovician was an enigmatic interval in the Phanerozoic, known for massive glaciation potentially at elevated CO(2) levels, biogeochemical cycle disruptions recorded as large isotope anomalies and a devastating extinction event. …”
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  14. 1974
  15. 1975
  16. 1976
    por Di, Jia, Jiang, Zhenxing, Yang, Min
    Publicado 2014
    “…Although soft tissue and vascular calcifications are common in CKD and progress as an independent risk factor of all-cause mortality, tumour calcification and calciphylaxis are uncommon in patients with end-stage renal disease (ESRD). Here, we discuss a rare case of a patient with tumour calcification complicated with calciphylaxis developed septic shock from infection. …”
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  17. 1977
  18. 1978
    “…The end of the last interglacial period, ~118 kyr ago, was characterized by substantial ocean circulation and climate perturbations resulting from instabilities of polar ice sheets. …”
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  19. 1979
  20. 1980
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