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1221por Li, Yubin, Chen, Runzhe, Yang, Jian, Mo, Shaowei, Quek, Kelly, Kok, Chung H., Cheng, Xiang-Dong, Tian, Saisai, Zhang, Weidong, Qin, Jiang-Jiang“…Network system biology based on the protein–protein interaction (PPI) network was also performed to identify the most connected and important genes based on our DEGs. The top five hub genes including osteopontin (SPP1), Collagen alpha-2(I) chain (COL1A2), Insulin-like growth factor I (IGF1), lipoprotein A (LPA), and Galectin-3 (LGALS3) were identified. …”
Publicado 2020
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1222por Samuel, Michelle, Batomen, Brice, Rouette, Julie, Kim, Joanne, Platt, Robert W, Brophy, James M, Kaufman, Jay S“…METHODS: A PubMed search for cardiovascular PS articles published between 2010 and 2017 in high-impact general medical (top five by impact factor) and cardiovascular (top three by impact factor) journals was performed. …”
Publicado 2020
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1223“…PIK3CD, NLRC3, FMNL1, TRAF3IP3 and CR1 were the top five hub genes of the blue coexpression module positively correlated with pathological tumour stage and lymph node stage (p values <0.05 for all cases). …”
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1224“…The combination of only the top five variables in the stepwise model (AUC = 0.901 and sensitivity = 0.880) has as a good a predictive ability as other models. …”
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1225“…The global risks report of 2020 stated, climate-related issues dominate all of the top-five long-term critical global risks burning the planet and according to the report, “as existing health risks resurge and new ones emerge, humanity’s past successes in overcoming health challenges are no guarantee of future results.” …”
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1226por van der Walt, Martie, Masuku, Sikhethiwe, Botha, Sonja, Nkwenika, Tshifhiwa, Keddy, Karen H.“…BACKGROUND: Tuberculosis (TB) is amongst the top five causes of death in women of childbearing age (15-≤44 years). …”
Publicado 2020
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1227por BrintzenhofeSzoc, Karlynn, Krok-Schoen, Jessica I., Pisegna, Janell L., MacKenzie, Amy R., Canin, Beverly, Plotkin, Elana, Boehmer, Leigh M., Shahrokni, Armin“…Most respondents agreed (86.3%) that decision making about Do Not Resuscitate orders should be the result of discussion with the patient and the healthcare proxy in all situations. The top five concerns reported were related to patient safety, treatment delays, healthcare worker mental health and burnout, and personal safety for family and self. …”
Publicado 2021
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1228“…Using CMap analysis, we discovered 10 small molecular compounds that reversed the altered DEGs, the top five are phenoxybenzamine, adiphenine, resveratrol, and trifluoperazine. …”
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1229“…Further, from the gene regulatory network analysis, the top five hub genes HMOX1, DNMT1, PLAT, GDF1, and ITGB1 are found to be involved in interferon (IFN)-α2b induction, epigenetic modification, and modulation of anti-viral activity. …”
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1230por Somanadhan, Suja, Nicholson, Emma, Dorris, Emma, Brinkley, Aoife, Kennan, Avril, Treacy, Eileen, Atif, Awan, Ennis, Sean, McGrath, Vicky, Mitchell, Derick, O’Sullivan, Grace, Power, Julie, Lawlor, Anne, Harkin, Paul, Lynch, Sally Ann, Watt, Philip, Daly, Avril, Donnelly, Susie, Kroll, Thilo“…Seventy-five individuals completed the phase III prioritisation ranking survey and ranked the top 15 research priorities. The top five priorities were (1)Support at the time of diagnosis, (2) Diagnostic test for rare diseases (3)Education and training (4) Patient voice (5) Data sharing and integration of services for rare diseases. …”
Publicado 2020
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1231“…A citation analysis of 1412 references from research articles published in 2017 in the top five Med Ed journals was undertaken. A typology of six knowledge clusters was inductively developed. …”
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1232“…Moreover, in random forest analysis, the daily average dietary intakes of SFA, vitamin A, total fat/oil, β-carotene, and cholesterol were among the top five nutrients (out of 12 nutrients variables) of relative importance associated with CAD. …”
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1233Hub genes and key pathways of traumatic brain injury: bioinformatics analysis and in vivo validationpor Tang, Yun-Liang, Fang, Long-Jun, Zhong, Ling-Yang, Jiang, Jian, Dong, Xiao-Yang, Feng, Zhen“…Moreover, the hub genes with high connectivity degrees were primarily related to inflammatory mediators. To validate the top five hub genes, a rat model of TBI was established using the weight-drop method, and real-time quantitative polymerase chain reaction analysis of the cerebral cortex was performed. …”
Publicado 2020
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1234por Ayaad, Mohammed, Han, Zhongmin, Zheng, Kou, Hu, Gang, Abo-Yousef, Mahmoud, Sobeih, Sobeih El. S., Xing, Yongzhong“…The superior parental alleles for GS3, GL3.1, GW5, GW7, and Chalk5 and two QTLs were almost carried by the high-quality parents Cypress and Yuejingsimiao (YJSM), while the poor-quality parent Guichao-2 (GC2) always carried the inferior alleles. The top five recombinant inbred lines with the highest quality of grain shape and chalkiness traits all carried gene combinations of superior alleles. …”
Publicado 2020
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1235“…RESULTS: COVID-19-related hospitalizations were associated with all selected chronic conditions, except osteoporosis and Alzheimer disease/dementia among COVID-19 MBs. The top five conditions with the highest odds for hospitalization among COVID-19 MBs were end-stage renal disease (adjusted odds ratios (aOR): 2.15; 95% CI: 2.10–2.21), chronic kidney disease (aOR: 1.54; 95% CI: 1.52–1.56), acute myocardial infarction (aOR: 1.45; 95% CI: 1.39–1.53), heart failure (aOR: 1.43; 95% CI: 1.41–1.44), and diabetes (aOR: 1.37; 95% CI: 1.36–1.39). …”
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1236“…Finally, RNA expression of top five differentially expressed autophagy-related genes was validated in blood samples from COPD patients and healthy controls by qRT-PCR. …”
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1237“…In Canada, concussion is among the top five reasons for workplace time-loss. Concussion results in physical, cognitive, and/or emotional symptoms that temporarily worsen with physical and mental exertion, such as viewing electronic screens. …”
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1238“…Camellia japonica and its hybrids represent 18,141 or 74.10%, followed by those of C. reticulata and its hybrids (1,432 or 5.85%) and C. sasanqua and its hybrids (1,291 or 5.27%). The top five countries of origin are USA (7,502 cultivars), Japan (6,592), Italy (2,833), China (2,066) and Australia (1,216). …”
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1239por Patel, Chirag N., Goswami, Dweipayan, Jaiswal, Dharmesh G., Parmar, Robin M., Solanki, Hitesh A., Pandya, Himanshu A.“…A total of 110 phytochemicals from Withania somnifera, Asparagus racemosus, Zinziber officinalis, Allium sativum, Curcuma longa and Adhatoda vasica were used in the study, of which Racemoside A, Ashwagandhanolide, Withanoside VI, Withanoside IV and Racemoside C were identified as top five hits using molecular docking. Further, essential Pharmacophore features and their ADMET profiles of these compounds were studied following to which the best three hits were analyzed for their interaction with RBD using Molecular Dynamics (MD) simulation. …”
Publicado 2021
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1240por Phan, Isabelle Q., Subramanian, Sandhya, Kim, David, Murphy, Michael, Pettie, Deleah, Carter, Lauren, Anishchenko, Ivan, Barrett, Lynn K., Craig, Justin, Tillery, Logan, Shek, Roger, Harrington, Whitney E., Koelle, David M., Wald, Anna, Veesler, David, King, Neil, Boonyaratanakornkit, Jim, Isoherranen, Nina, Greninger, Alexander L., Jerome, Keith R., Chu, Helen, Staker, Bart, Stewart, Lance, Myler, Peter J., Van Voorhis, Wesley C.“…We showed that two of our top five candidates, the N-terminal fragment of the nucleoprotein and the receptor-binding domain of the spike protein, have the highest sensitivity and specificity and signal-to-noise ratio for detecting COVID-19 sera/plasma by ELISA. …”
Publicado 2021
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