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  1. 1381
    “…KEGG analysis revealed that the top five pathways related to hsa_circRNA_0023313 were endocytosis, meiosis, FoxO signaling pathway, ubiquitin mediated proteolysis and AMPK signaling pathway. …”
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    CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia
  2. 1382
    “…Overall, a higher proportion of Ascomycota (~70%) over Basidiomycota was recovered in the yellow sediment and the two phyla were equally abundant in the black sediment. The top five dominant fungal orders in descending order based on species richness were Pleosporales>Eurotiales>Polyporales>Hypocreales>Capnodiales in the black sediment samples, and Polyporales>Pleosporales>Eurotiales>Capnodiales>Hypocreales in the yellow sediment samples. …”
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    Insights into fungal diversity of a shallow-water hydrothermal vent field at Kueishan Island, Taiwan by culture-based and metabarcoding analyses
  3. 1383
    “…First, we analysed the miRNA repertoire of E. multilocularis primary cells by small RNA-seq and found that miR-71, a bilaterian miRNA absent in vertebrate hosts, is one of the top five most expressed miRNAs. Using genomic information and bioinformatic algorithms for miRNA binding prediction, we found a high number of potential miR-71 targets in E. multilocularis. …”
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    Deciphering the role of miR-71 in Echinococcus multilocularis early development in vitro
  4. 1384
    “…BACKGROUND: The incidence and mortality rates of gastric cancer (GC) rank in top five among all malignant tumors. Chemokines and their receptor-signaling pathways reportedly play key roles in the metastasis of malignant tumor cells. …”
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    RANKL/RANK promotes the migration of gastric cancer cells by interacting with EGFR
  5. 1385
    “…The incidence of HAI in elderly patients was significantly higher than that in non-elderly patients (2.6% vs. 1.5%, χ(2) = 202.421, P < 0.01) and increased with age. The top five sites of HAIs in the elderly were the lower respiratory tract, urinary tract, blood stream, antibiotic-associated diarrhea, and surgical site. …”
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    Epidemiological and clinical characteristics of healthcare-associated infection in elderly patients in a large Chinese tertiary hospital: a 3-year surveillance study
  6. 1386
    “…RESULTS: Epithelial ovarian cancer sequencing projects identify recurrent genomic RET missense mutations in 1.98% of patients, ranking as the top-five hit among the 100 receptor tyrosine kinases-encoding genes. …”
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    Oncogenic and drug-sensitive RET mutations in human epithelial ovarian cancer
  7. 1387
    “…METHODS: Each committee member independently gave their top five priorities for sepsis research. A total of 88 suggestions (ESM 1 - supplemental table 1) were grouped into categories by the committee co-chairs, leading to the formation of seven subgroups: infection, fluids and vasoactive agents, adjunctive therapy, administration/epidemiology, scoring/identification, post-intensive care unit, and basic/translational science. …”
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    Surviving sepsis campaign: research priorities for sepsis and septic shock
  8. 1388
    “…Additionally, participants created a top five important outcomes. Next, we performed a systematic review (SR) on niche-related outcomes and compared the FGDs with niche-related outcomes from the SR. …”
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    Niche-related outcomes after caesarean section and quality of life: a focus group study and review of literature
  9. 1389
    por Akalu, Yonas, Belsti, Yitayeh
    Publicado 2020
    “…Even though Ethiopia is Africa’s first country among the top five in the prevalence of DM, there is a paucity of data on hypertension and its associated factors among patients with type 2 diabetes mellitus. …”
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    Hypertension and Its Associated Factors Among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia
  10. 1390
    “…Access to the treatment for the top five morbidities was after 4 days of symptoms’ recognition. …”
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    Under 10 mortality patterns, risk factors, and mechanisms in low resource settings of Eastern Uganda: An analysis of event history demographic and verbal social autopsy data
  11. 1391
    “…RESULTS: Overall, the top five factors to predict survival in order of importance were: initial rhythm, age, early Cardiopulmonary Resuscitation (CPR, time to CPR and CPR before arrival of EMS), time from EMS dispatch until EMS arrival, and place of cardiac arrest. …”
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    Identifying the relative importance of predictors of survival in out of hospital cardiac arrest: a machine learning study
  12. 1392
    “…For all age categories, beef (excludes ground) was among the top five sources and egg/omelets appear in the top ten sources. …”
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    Age and Racial/Ethnic Differences in Dietary Sources of Protein, NHANES, 2011–2016
  13. 1393
    “…The results showed that the standard deviation of seasonal changes in temperature (40.6%), precipitation in October (15.7%), vegetation type (14.3%), soil type (9.2%), and mean sunshine duration in the growing season (9.1%) were the top five most influential factors out of the 17 main ecological factors affecting the distribution of A. membranaceus var. mongholicus. …”
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    Ecological niche modeling of Astragalusmembranaceus var. mongholicus medicinal plants in Inner Mongolia, China
  14. 1394
    “…In total, 39.4% (n=544) of the patients chose to get their medicine by self-pickup, while 60.6% (n=836) preferred to receive their medicine via drug delivery service. The top five online prescription departments were infectious diseases (n=572, 41.4%), nephrology (n=264, 19.1%), endocrinology (n=145, 10.5%), angiocardiopathy (n=107, 7.8%), and neurology (n=42, 3%). …”
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    The Internet Hospital Plus Drug Delivery Platform for Health Management During the COVID-19 Pandemic: Observational Study
  15. 1395
    “…BACKGROUND: Pakistan is among top five high burden countries for tuberculosis and drug resistant TB. …”
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    Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates/from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19
  16. 1396
    “…However, moral value seems to come in degrees, and some strengths were valued more strongly than others (top five: judgment, honesty, kindness, fairness, and hope). …”
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    Scrutinizing the Criteria for Character Strengths: Laypersons Assert That Every Strength Is Positively Morally Valued, Even in the Absence of Tangible Outcomes
  17. 1397
    “…After PPI network construction, the top five hub genes associated with hypothyroidism were extracted, including ALB, MAPK1, SPP1, PPARG, and MIF, whereas those associated with hyperthyroidism were ALB, FCGR2B, CD44, LCN2, and CD74. …”
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    Integrative analysis of key candidate genes and signaling pathways in autoimmune thyroid dysfunction related to anti-CTLA-4 therapy by bioinformatics
  18. 1398
    “…The MS/MS screening results in 2019 showed free carnitine deficiency, which was consistent with the genetic findings. The top five genes with the highest carrier frequencies of mutations in these newborns were PAH (1:56, 1.79%), ETFDH (1:81, 1.23%), MMACHC (1:87, 1.15%), SLC25A13 (1:102, 0.98%), and GCDH (1:125, 0.80%). …”
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    A pilot study of expanded newborn screening for 573 genes related to severe inherited disorders in China: results from 1,127 newborns
  19. 1399
    “…Insufficient intake of fruit and vegetables, alcohol use, and high blood pressure were among the top five risk factors in both communities. Physical inactivity ranked among the top two risk factors in the urban community; while alcohol and tobacco use was significantly higher in the rural community. …”
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    A Comparison of the Socio-Behavioral-Metabolic Risk Profiles and Associated Factors for Chronic Diseases of Lifestyle in Urban and Rural Communities in Central South Africa
  20. 1400
    “…Of the 17 features identified as important for a patient navigator programme, the top five were delivery of education, psychosocial support, lifestyle modification, communication and decision-making support and facilitating care. …”
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    Patient needs and priorities for patient navigator programmes in chronic kidney disease: a workshop report
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