Mostrando 81 - 100 Resultados de 224 Para Buscar '"Two Car"', tiempo de consulta: 0.39s Limitar resultados
  1. 81
    “…Furthermore, HER2 CAR T cells provided a significant regression in intracranial DIPG xenograft tumors. …”
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    HER2 chimeric antigen receptor T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma
  2. 82
    “…The expression of anti-VEGFR2 CAR on murine and human T cells was detected with approximately 100% efficiency for a few days, after peaking 6–12 hours after mRNA-EP. …”
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    Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research
  3. 83
    “…In vitro co-culture experiments revealed the effective killing of Y79RB cells by GD2-CAR T cells, but not by control CD19-CAR T cells. …”
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    GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma – assessing tumor and T cell interaction
  4. 84
    “…METHODS: GD2 expression was evaluated in tumor cell lines and tumor biopsies by flow cytometry and immunohistochemistry. We used a GD2.CAR that coexpress the IL-15 to promote T-cell proliferation and persistence, and the inducible caspase 9 gene safety switch to ablate GD2.CAR-T cells in case of unforeseen toxicity. …”
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    Targeting disialoganglioside GD2 with chimeric antigen receptor-redirected T cells in lung cancer
  5. 85
    “…HER2 CAR T cells proliferate and traffic into the tumor, but this causes a dramatic influx of immune cells, tumor swelling and lethal toxicity in a subset of mice. …”
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    IMMU-20. EVALUATION OF CAR T CELLS IN EPENDYMOMA
  6. 86
    “…Our data support further exploration of the HER2 CAR T-cell therapy for HER2-expressing cancers.…”
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    Construction and evaluation of a novel humanized HER2-specific chimeric receptor
  7. 87
    “…Furthermore, co-culture with RD-IL15-secreting GD(2)-CAR NK cells markedly enhanced proliferation and cytotoxicity of bystander immune cells in a paracrine manner. …”
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    Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD(2)-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2
  8. 88
    “…CONCLUSIONS: Enrichment of PBMC concentrates for lymphocytes using elutriation increased the quantity of GD2-CAR T cells produced. These results provide further evidence that CAR T cell expansion is inhibited by monocytes and granulocytes.…”
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    Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells
  9. 89
    “…Furthermore, mSA2 CAR T cells were capable of mediating cancer cell lysis and IFNγ production in an antibody dose-dependent manner. …”
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    mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting
  10. 90
    “…This work presents a study of the traction, normal and stall forces in a two-sided planar actuator with orthogonal planar windings and a mover that comprises two cars magnetically coupled to each other through two pairs of permanent magnets (PMs). …”
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    Static Characterization of the Driving, Normal and Stall Forces of a Double-Sided Moving-Permanent Magnet-Type Planar Actuator Based on Orthogonal Planar Windings
  11. 91
    “…In addition, D1D2CAR does not mediate HIV infection or stimulation mediated by IL-16, suggesting lower risk of off-target effects. …”
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    Robust CAR-T memory formation and function via hematopoietic stem cell delivery
  12. 92
    “…Administration of mACE2-CAR_sIL15 NK cells maintains body weight, reduces viral load, and prolongs survival of transgenic mice expressing human ACE2 upon infection with live SARS-CoV-2. …”
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    Off-the-shelf CAR natural killer cells secreting IL-15 target spike in treating COVID-19
  13. 93
    “…In NB, IDO1 is able to inhibit the anti-tumor effect displayed by of both anti-GD2 CAR (GD2.CAR) T-cell and NK cells, mainly by impairing their IFNγ production. …”
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    GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape
  14. 94
    “…Trastuzumab-based HER2 CAR-T constructs have demonstrated preclinical efficacy in medulloblastoma and are being evaluated for use in children and young adults with recurrent or refractory CNS tumors. …”
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    EPEN-26. Chemokine receptor blockade reverses CCL2 mediated immunosuppression and restores CAR-T cell function in posterior fossa ependymoma
  15. 95
    “…This anti-GD2 CAR represents a powerful new tool to redirect T cells against GD2. …”
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    A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing
  16. 96
    “…In conclusion, our studies provide scientific evidence that HER2 CAR-T cells represent an emerging immunotherapy for the treatment of mCRC.…”
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    HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer
  17. 97
    “…P2 gel beads adsorbed 30–42 mg/g of bovine serum albumin (BSA) depending on pH. P2-Car0.2, P2-Car0.5, and P1.5-Car0.5 beads reduced BSA adsorption by 3.1, 5.2, and 4.0 times compared to P2 beads, respectively, at pH 7. …”
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    Characterization and Biocompatibility Properties In Vitro of Gel Beads Based on the Pectin and κ-Carrageenan
  18. 98
    “…Humanized IL-13Rα2 CAR T cells also demonstrated benefit from a self-secreted anti-CTLA-4 minibody in the same mouse model. …”
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    Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas
  19. 99
    “…In co-culture experiments, target-activated anti-HER2.CAR/NK-92 cells modified surrounding tumor cells and bystander immune cells by triggering the release of inflammatory cytokines and upregulation of PD-L1. …”
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    AAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastoma
  20. 100
    “…In vitro cytotoxicity against a breast cancer tumour cell line was not altered by c-FLIPp43 expression, but the expression of c-FLIPp43 in Her2-CAR T cells lowered interferon-γ secretion, without markedly affecting IL-2 levels, and c-FLIPp43-Her2-CAR T cells showed reduced anti-tumour activity in immunodeficient mice with breast cancer. …”
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    Anti-Apoptotic c-FLIP Reduces the Anti-Tumour Activity of Chimeric Antigen Receptor T Cells
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