Mostrando 121 - 140 Resultados de 224 Para Buscar '"Two Car"', tiempo de consulta: 0.35s Limitar resultados
  1. 121
    “…Collectively, our results suggest that a truncated anti-GD2 CAR might be a powerful new tool to redirect MSCs carrying TRAIL against GD2-expressing tumors. …”
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    Targeting GD2-positive glioblastoma by chimeric antigen receptor empowered mesenchymal progenitors
  2. 122
    “…Cell culture assays demonstrated substantial GD2 CAR T-cell-mediated killing of murine GBM cell lines SB28 and GL26 induced to overexpress GD2. …”
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    Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model
  3. 123
    “…Furthermore, the combination with this small molecule facilitated the anti-HER2 CAR T cell-mediated elimination of tumor cells in a xenograft mouse model. …”
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    BAY 60-6583 Enhances the Antitumor Function of Chimeric Antigen Receptor-Modified T Cells Independent of the Adenosine A2b Receptor
  4. 124
    “…This study aimed to explore whether interleukin (IL)-7 and CCR2b expression could improve GD2-CAR-T cell survival and infiltration in neuroblastoma and melanoma treatment. …”
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    IL-7 and CCR2b Co-Expression-Mediated Enhanced CAR-T Survival and Infiltration in Solid Tumors
  5. 125
    por Vannucci, François
    Publicado 2005
    “…François Vannucci commence donc par nous décrypter E=mc2. Car cette fameuse formule résume la révolution qu’apporta la théorie : énergie et masse ne sont plus des quantités indépendantes, elles sont reliées par la vitesse de la lumière. …”
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    Qu'est-ce que la relativité ?
  6. 126
    “…To represent this, we utilized CAR-T testing approach and treated GD2-positive HGG organoids with GD2 CAR-T cells and control CD19 CAR-T cells. 72h exposure to GD2 CAR-T induced morphological changes and significant increase in dead cells within organoids, which was not observed in CD19 CAR-T treated counterparts (p<0.05). …”
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    BIOL-21. PATIENT-DERIVED, THREE-DIMENSIONAL ORGANOID PLATFORM FOR PEDIATRIC BRAIN TUMOR MODELING AND THERAPEUTIC TESTING
  7. 127
    “…Tumors from DOC-treated mice exhibited higher expression of HMGB1 and CXCL11, more HER2-CAR T cell infiltration, and reduced progression, relative to control. …”
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    Cancer-cell-secreted CXCL11 promoted CD8(+) T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC
  8. 128
    “…Mechanistically, CAR10 induced epithelial-to-mesenchymal transition (EMT) by directly binding with miR-30 and miR-203 and then regulating the expression of SNAI1 and SNAI2. CAR10 overexpression was positively correlated with a poor prognosis in LUAD patients, whereas overexpression of both CAR10 and SNAI was correlated with even worse clinical outcomes. …”
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    Long noncoding RNA CAR10 promotes lung adenocarcinoma metastasis via miR-203/30/SNAI axis
  9. 129
    “…We study here the vehicle-to-vehicle (V2V) visible light communication (VLC) between two cars moving along different roadway scenarios: (i) a multiple-lane rectilinear roadway and (ii) a multiple-lane curvilinear roadway. …”
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    Cooperative Full-Duplex V2V-VLC in Rectilinear and Curved Roadway Scenarios
  10. 130
    “…ABSTRACT: The disialoganglioside GD2 is a tumor-associated antigen that may allow for the application of targeted immunotherapies (anti-GD2 antibodies, GD2 CAR T cells) in patients with neuroblastoma and other solid tumors. …”
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    Variable Expression of the Disialoganglioside GD2 in Breast Cancer Molecular Subtypes
  11. 131
    “…Importantly, after the recent market approval of 2 CAR-T cell constructs, the application of CAR-T cells will expand to nonacademic centers with limited experience in the management of CAR-T cell-associated toxicities. …”
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    In the Eye of the Storm: Immune-mediated Toxicities Associated With CAR-T Cell Therapy
  12. 132
    “…METHODS: Primary murine T cells were retrovirally transduced to express a 2G anti-VEGFR-2-CAR, and the in vitro binding to VEGFR-2, as well as reactivity against TA-expressing cells, was evaluated in the absence versus presence of exogenous VEGF-A. …”
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    VEGFR-2 redirected CAR-T cells are functionally impaired by soluble VEGF-A competition for receptor binding
  13. 133
    “…We generated murine T cells expressing IL13Rα2-CARs and secretory IL15 (CAR.IL15s) or IL13Rα2-CARs in which IL15 was fused to the CAR to serve as an IL15Rα-targeting moiety (CAR.IL15f), and characterized their effector function in vitro and in syngeneic IL13Rα2+glioma models. …”
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    IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM
  14. 134
    “…Preliminary results of multiple clinical trials, including GD2- and HER2-CAR-T cells, are encouraging but must be reproduced and validated on a larger scale. …”
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    CAR-T Therapies in Solid Tumors: Opportunities and Challenges
  15. 135
    “…Cranial MRI and ultrasound showed no mass; (123)I‐metaiodobenzylguanidine ((123)I‐MIBG) scan was negative. CONCLUSION: GD2‐CAR‐T cells may be an effective treatment option for NB patients with MYCN amplification.…”
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    4SCAR‐GD2‐modified T‐cell therapy in neuroblastoma with MYCN amplification: A case report with over 4‐year follow‐up data
  16. 136
    “…Non-human primates (NHPs) bearing ventricular and lumbar reservoirs were treated with target autologous cells bearing extracellular HER2 followed by autologous HER2-CAR T cells intraventricularly. Cerebrospinal fluid and blood were collected serially to measure the persistence of delivered cells and cytokines. …”
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    Durable regression of Medulloblastoma after regional and intravenous delivery of anti-HER2 chimeric antigen receptor T cells
  17. 137
    “…To advance this concept to the clinic and assess its safety in an immune-competent and human-patient-like setting, we treated four companion dogs with autologous anti-HER2 CAR-TILs. We found that these cells were tolerable and showed signs of anti-tumor activity. …”
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    Treatment with Anti-HER2 Chimeric Antigen Receptor Tumor-Infiltrating Lymphocytes (CAR-TILs) Is Safe and Associated with Antitumor Efficacy in Mice and Companion Dogs
  18. 138
    “…We incorporated 4-1BB into the anti-GD2 CAR-T cells to test their cytotoxicity in melanoma in vitro and in vivo. …”
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    Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients
  19. 139
    “…Furthermore, PD-L1 CCR also improved the antitumor efficacy of the low-affinity HER2 CAR-T cells against PD-L1(+) tumors expressing high levels of HER2. …”
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    PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo
  20. 140
    “…The contrasting effects of the two CARs on the lung transcriptome were further uncovered in mice exposed to cigarette smoke (CS) for 3 days; only LY activated ~50 genes detected in the lungs of CS-exposed mice. …”
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    Effects of dietary carotenoids on mouse lung genomic profiles and their modulatory effects on short-term cigarette smoke exposures
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