Mostrando 141 - 160 Resultados de 224 Para Buscar '"Two Car"', tiempo de consulta: 0.42s Limitar resultados
  1. 141
    “…Here, we describe the development of an anti-annexin A2 CAR, CAR(2448), derived from an antibody found to have activity against epithelial ovarian cancer cell lines. …”
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    Preclinical Activity of Embryonic Annexin A2-Specific Chimeric Antigen Receptor T Cells Against Ovarian Cancer
  2. 142
    “…In this study, we build on our previous work in the development of HLA‐A2 CAR‐Tregs by further equipping cells with the constitutive expression of interleukin 10 (IL‐10) and an imaging reporter as additional payloads. …”
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    Chimeric antigen receptor‐modified human regulatory T cells that constitutively express IL‐10 maintain their phenotype and are potently suppressive
  3. 143
    “…Here we found that murine GD2 CAR-T cells, specific for the tumor-associated antigen GD2, induce fatal neurotoxicity in a costimulatory domain-dependent manner. …”
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    Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma
  4. 144
    “…Its activity was enhanced by some cations (Na(+), K(+), and Fe(2+)), but inhibited or inactivated by others (Sr(2+), Ca(2+), Ni(2+), Ba(2+), Mn(2+), Cu(2+), Fe(3+), and Mg(2+)). Car1383 degraded carrageenan into neocarrabiose and neocarratetraose. …”
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    Biochemical Characterization of a Carrageenase, Car1383, Derived From Associated Bacteria of Antarctic Macroalgae
  5. 145
    “…In addition, we used a receiver operating characteristic graph to determine the optimal standard version of the CARS-2 (CARS2-ST) cutoff score for ASD diagnosis using the ADOS-2. …”
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    A Validation Study of the CARS-2 Compared With the ADOS-2 in the Diagnosis of Autism Spectrum Disorder: A Suggestion for Cutoff Scores
  6. 146
    “…This manufacturing strategy is currently under clinical investigation in patients receiving allogeneic HSCT for relapsed neuroblastoma and B-cell malignancies (NCT01460901 using a GD2.CAR and NCT00840853 using a CD19.CAR). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40425-015-0049-1) contains supplementary material, which is available to authorized users.…”
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    Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: a Production Assistant for Cell Therapy (PACT) translational application
  7. 147
    “…Preclinical characterization demonstrated antigen-specific GD(2)-CAR mediated activation after co-cultivation with GD(2)-expressing target cells. …”
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    GMP-Compliant Manufacturing of TRUCKs: CAR T Cells targeting GD(2) and Releasing Inducible IL-18
  8. 148
    “…CASE REPORT: A 48-year-old male was involved in an accident in which 2 cars collided. The patient suffered from right-sided hemothorax due to diaphragm rupture and stripping of the diaphragmatic pillar. …”
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    Thoracic Damage Control: Let’s Think About Intrathoracic Packing
  9. 149
    “…Lenalidomide also enhanced the cytotoxicity against MDA-MB-453 and the cytokine secretion of HER2-CAR T cells but did not affect their proliferation significantly. …”
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    Lenalidomide Enhances CAR-T Cell Activity Against Solid Tumor Cells
  10. 150
    por Seong, Gyuhee, D’Angelo, Sandra P.
    Publicado 2023
    “…Genetically modified T-cell receptor therapy targeting cancer testis antigens such as NY-ESO-1 and MAGE-A4 demonstrated durable responses, especially in synovial sarcoma. Two early HER2-CAR T-cell trials have achieved stable disease in some patients. …”
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    New therapeutics for soft tissue sarcomas: Overview of current immunotherapy and future directions of soft tissue sarcomas
  11. 151
    “…These layers alternate with layers of pyrazine-2-car­bo­nitrile mol­ecules and both are held together via C—H⋯N hydrogen bonds and further π–π stacking inter­actions.…”
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    Di­aqua­bis­[5-(2-pyrazin-2-yl)tetra­zolato]copper(II)–pyrazine-2-carbo­nitrile (1/2)
  12. 152
    “…We have utilized these circuits to control the expression of an anti-Her2-CAR, demonstrating the ability of these circuits to regulate CAR expression and T cell activity. …”
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    Inducible Gene Switches with Memory in Human T Cells for Cellular Immunotherapy
  13. 153
    “…We explore the use of cell-based therapies, oncolytic virotherapy or immunovirotherapy, immune checkpoint inhibition, and immunomodulatory vaccination strategies, and highlight the recent clinical success of anti-GD2 CAR-T therapy in diffuse intrinsic pontine glioma (DIPG) patients. …”
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    Immunotherapy approaches for the treatment of diffuse midline gliomas
  14. 154
    “…Finally, we have observed that HER-2–CAR T cells stimulate PD-L1 expression on MCF-7 cells and therefore accelerate the functionality of PD-L1–CAR T cells when used in combination. …”
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    PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells
  15. 155
    “…The first one (HER2-TEV) expresses an anti-human epidermal growth factor receptor 2 (HER2) CAR single chain variable fragment (scFv), with CD28 and CD3z co-stimulatory domains linked to the tobacco etch virus (TEV) protease and two single guide RNAs (sgRNA) targeting the interleukin (IL)-12A and IL12B transcription start site (TSS), respectively. …”
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    Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment
  16. 156
    “…For CARs with high tonic signaling (e.g., GD2.CAR and CSPG4.CAR), reducing PCPs on CARs or boosting ionic strength in the culture medium during ex vivo CAR-T cell expansion minimizes spontaneous CAR activation and alleviates CAR-T cell exhaustion. …”
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    Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
  17. 157
    “…T cells expressing any of these two CARs demonstrated superior tumor inhibitory effects in vitro and in two xenograft mouse models. …”
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    IL-13Rα2 humanized scFv-based CAR-T cells exhibit therapeutic activity against glioblastoma
  18. 158
    “…Several studies on HLA-A2 specific CAR Tregs have demonstrated that these cells are highly antigen-specific and show a superior homing capacity to HLA-A2+ allografts compared to polyclonal Tregs. HLA-A2 CAR Tregs have been shown to prolong survival of HLA-A2+ allografts in several pre-clinical humanized mouse models. …”
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    Chimeric Antigen Receptor (CAR) Regulatory T-Cells in Solid Organ Transplantation
  19. 159
    “…HER-2 targeted therapies, such as monoclonal antibodies (mAbs) and CAR-T cell therapy have been applied in the treatment of various of cancers. However, the anti-HER2 CAR-T cell therapy are limited by its expensive production procedure and fatal side effects such as cytokine storm or “On target, off tumor”. …”
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    Anti-HER2 scFv-CCL19-IL7 recombinant protein inhibited gastric tumor growth in vivo
  20. 160
    “…Furthermore, compared to those with no ACEs, those with 4+ were around two times more likely to report having had multiple (i.e., 2+) car crashes and over four times more likely to report having had burns multiple times. …”
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    Associations between Adverse Childhood Experiences (ACEs) and Lifetime Experience of Car Crashes and Burns: A Cross-Sectional Study
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