Mostrando 161 - 180 Resultados de 224 Para Buscar '"Two Car"', tiempo de consulta: 6.85s Limitar resultados
  1. 161
    “…The aim of this review is to present new findings in the treatment of CLDN18.2-positive GEAC, with a particular focus on the monoclonal antibody zolbetuximab and on the use of engineered anti-CLDN18.2 CAR-T cells.…”
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    Anti-Claudin Treatments in Gastroesophageal Adenocarcinoma: Mainstream and Upcoming Strategies
  2. 162
    “…PLP in the active site may be a promising target for development of selective inhibitors of PLP-dependent enzymes, including RSS-generating enzymes such as cystathionine β-synthase (CBS) and cysteinyl-tRNA synthetase 2 (CARS2), which have unique substrate binding pocket structures.…”
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    Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation
  3. 163
    “…We developed and tested the Indian Autism Screening Questionnaire (IASQ), which was reported to be reliable and valid as compared to the Indian Scale for Assessment of Autism (ISAA) and the Childhood Autism Rating Scale -2 (CARS2). The present study describes the feasibility, acceptability, sociodemographic and developmental details of IASQ study participants in 5 settings- a psychiatry outpatients’ clinic (n = 145), a specialised paediatric clinic (n = 24), a speciality disability centre (n = 174), a primary school (n = 41) and a government housing colony (n = 255). …”
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    Feasibility and acceptability of the Indian Autism Screening Questionnaire in clinical and community settings
  4. 164
    “…In parallel measurements with fura-2, CaR activation elicited robust Ca(2+) oscillations that increased in frequency in the presence of cAMP, eventually fusing into a sustained plateau. …”
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    Termination of cAMP signals by Ca(2+) and Gα(i) via extracellular Ca(2+) sensors: a link to intracellular Ca(2+) oscillations
  5. 165
    “…Using a novel CA VII (Car7) knockout (KO) mouse as well as a CA II (Car2) KO and a CA II/VII double KO, we show that mature hippocampal pyramidal neurons are endowed with two cytosolic isoforms. …”
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    Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures
  6. 166
    “…METHODS: We prepared second generation anti-HER2 CARs that were targeted to the tumor antigen by either a DARPin or scFv. …”
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    Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
  7. 167
    “…In particular, the CD44v6-NWN2.CAR T cells are enriched in central memory cells and show improved in vitro functions in terms of killing capability, and in vivo antitumor activity against hematological and solid tumors. …”
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    Characterization and Functional Analysis of CD44v6.CAR T Cells Endowed with a New Low-Affinity Nerve Growth Factor Receptor-Based Spacer
  8. 168
    “…We demonstrated that GD2CAR-specific activation induced a tight NFκB-promoter-driven cytokine release in NK-92 and primary NK cells together with an enhanced cytotoxic capacity against GD2(+) target cells, also shown by increased secretion of cytolytic cytokines. …”
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    Generation of an NFκB-Driven Alpharetroviral “All-in-One” Vector Construct as a Potent Tool for CAR NK Cell Therapy
  9. 169
    “…The chip assay confirmed a significant SRF signal in the Nr4a1 CArG box but not in the Rgs2 CArG box.…”
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    Early Phase of Plasticity-Related Gene Regulation and SRF Dependent Transcription in the Hippocampus
  10. 170
    “…We previously showed that a constitutively active IL7 receptor (C7R) enhanced the persistence, expansion, and anti-tumor activity of T-cells expressing chimeric antigen receptors (CARs), and C7R-modified GD2.CAR T-cells are currently undergoing clinical trials. …”
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    Constitutive Interleukin-7 Cytokine Signaling Enhances the Persistence of Epstein–Barr Virus-Specific T-Cells
  11. 171
    “…RESULTS: After adjusting for confounders the strongest individual and environmental correlates associated with ST was residential density (B = 0.14; p = 0.008), light-intensity PA was being a father/mother (B = 35.71; p = 0.025) and moderate-to-vigorous PA was sex (B = 0.91; p < 0.001) and number of cars (one car, B = −1.05; two cars, B = −1.14; p < 0.001). CONCLUSIONS: The associations found with individual and environmental correlates varied accordingly across all outcomes. …”
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    Individual and environmental correlates of objectively measured physical activity and sedentary time in adults from Curitiba, Brazil
  12. 172
    “…We further identified the D2 domain of CAR (D2-CAR) as the active domain responsible for binding to the short fibre of the novel FAdV-4. …”
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    Identification of chicken CAR homology as a cellular receptor for the emerging highly pathogenic fowl adenovirus 4 via unique binding mechanism
  13. 173
    “…Receiver operating characteristic curve analysis confirmed good prognostic performance of the new survival model with an area under the curve of 0.73. High FANCD2, CARS, and SLC7A11 expression and low HMGCR and NCOA4 expression were associated with high-risk ccRCC patients. …”
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    A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma
  14. 174
    “…Further study showed that the beneficial effect of serine was associated with enhanced NRF2/CAR signaling. Our result showed that serine attenuated doxorubicin-induced muscle weakness in mice. …”
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    Serine Supplementation Alleviates Doxorubicin-Induced Oxidative Damage in Skeletal Muscle of Mice
  15. 175
    “…Here we show that the Tumor-Specific Immuno-Gene (T-SIGn) virus NG-347 which encodes IFNα, MIP1α and CD80 synergizes with anti-EGFR CAR T cells as well as anti-HER-2 CAR T cells to clear A549 human tumor xenografts and their pulmonary metastases at doses which are subtherapeutic when each is used as a sole treatment. …”
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    T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice
  16. 176
    “…The maximum slab bending stress, slab acceleration, concrete base acceleration appear in the slab middle, at the slab end, and at the concrete base end, respectively. (3) The maximum accelerations of track components appear when the fifth or sixth wheel passes the measuring point, and at least two cars should be used. (4) The temperature gradient of slab track has a small influence on the car body acceleration. …”
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    Influence of temperature gradient of slab track on the dynamic responses of the train-CRTS III slab track on subgrade nonlinear coupled system
  17. 177
    “…T-cell redirection therapy using chimeric antigen receptor (CAR) T cells and bispecific antibodies (BiAbs) has shown promising efficacy in heavily pretreated patients with relapsed/refractory multiple myeloma (RRMM), leading to the approval of 2 CAR T-cell products and numerous BiAb trials. Data on the outcomes after relapse following BiAbs are urgently required to develop strategies for sequencing salvage therapies. …”
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    Sequencing T-cell redirection therapies leads to deep and durable responses in patients with relapsed/refractory myeloma
  18. 178
    “…Moreover, we have developed a CAR construct based on an affinity-optimized ACE2 and showed that both wild-type and affinity-optimized ACE2 CARs drive activation of a T cell line in response to SARS-CoV-2 Spike protein expressed on a pulmonary cell line. …”
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    Specific Activation of T Cells by an ACE2-Based CAR-Like Receptor upon Recognition of SARS-CoV-2 Spike Protein
  19. 179
    “…The expanded CIKZ cells exhibited antitumor cytotoxicity and could be modified to express anti-CD19 chimeric antigen receptor (CAR), anti-CEA CAR, and anti-HER2 CAR to enhance their specificity and cytotoxicity against CD19-, CEA-, or HER2-positive tumor cells. …”
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    Co-Expansion of Cytokine-Induced Killer Cells and Vγ9Vδ2 T Cells for CAR T-Cell Therapy
  20. 180
    “…METHODS: We created two CARs that contain the T cell receptor-ζ (TCR-ζ) signal transduction domain with the CD28 and CD137 (4-1BB) or CD134 (OX-40) intracellular domains in tandem (HELA/137CAR or HELA/134CAR). …”
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    CD137 Co-Stimulation Improves The Antitumor Effect Of LMP1-Specific Chimeric Antigen Receptor T Cells In Vitro And In Vivo
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