Proximity of immune and tumor cells underlies response to BRAF/MEK-targeted therapies in metastatic melanoma patients

por Yan, Chi, Chen, Sheau-Chiann, Ayers, Gregory D., Nebhan, Caroline A., Roland, Joseph T., Weiss, Vivian L., Johnson, Douglas B., Richmond, Ann
Publicado 2022

Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins

por Tsutsumi, Naotaka, Maeda, Shoji, Qu, Qianhui, Vögele, Martin, Jude, Kevin M., Suomivuori, Carl-Mikael, Panova, Ouliana, Waghray, Deepa, Kato, Hideaki E., Velasco, Andrew, Dror, Ron O., Skiniotis, Georgios, Kobilka, Brian K., Garcia, K. Christopher
Publicado 2022

SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia

por Han, Cuijuan, Khodadadi-Jamayran, Alireza, Lorch, Adam H., Jin, Qi, Serafin, Valentina, Zhu, Ping, Politanska, Yuliya, Sun, Limin, Gutierrez-Diaz, Blanca T., Pryzhkova, Marina V., Abdala-Valencia, Hiam, Bartom, Elizabeth Thomas, Buldini, Barbara, Basso, Giuseppe, Velu, Sadanandan E., Sarma, Kavitha, Mattamana, Basil B., Cho, Byoung-Kyu, Obeng, Rebecca C., Goo, Young Ah, Jordan, Philip W., Tsirigos, Aristotelis, Zhou, Yalu, Ntziachristos, Panagiotis
Publicado 2022

In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy

por Han, Jeong Pil, Kim, MinJeong, Choi, Beom Seok, Lee, Jeong Hyeon, Lee, Geon Seong, Jeong, Michaela, Lee, Yeji, Kim, Eun-Ah, Oh, Hye-Kyung, Go, Nanyeong, Lee, Hyerim, Lee, Kyu Jun, Kim, Un Gi, Lee, Jae Young, Kim, Seokjoong, Chang, Jun, Lee, Hyukjin, Song, Dong Woo, Yeom, Su Cheong
Publicado 2022

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

por Krstic, Jelena, Reinisch, Isabel, Schindlmaier, Katharina, Galhuber, Markus, Riahi, Zina, Berger, Natascha, Kupper, Nadja, Moyschewitz, Elisabeth, Auer, Martina, Michenthaler, Helene, Nössing, Christoph, Depaoli, Maria R., Ramadani-Muja, Jeta, Usluer, Sinem, Stryeck, Sarah, Pichler, Martin, Rinner, Beate, Deutsch, Alexander J. A., Reinisch, Andreas, Madl, Tobias, Chiozzi, Riccardo Zenezini, Heck, Albert J. R., Huch, Meritxell, Malli, Roland, Prokesch, Andreas
Publicado 2022

Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo

por Yeh, Chih-Fan, Cheng, Shih-Hsin, Lin, Yu-Shan, Shentu, Tzu-Pin, Huang, Ru-Ting, Zhu, Jiayu, Chen, Yen-Ting, Kumar, Sandeep, Lin, Mao-Shin, Kao, Hsien-Li, Huang, Po-Hsun, Roselló-Sastre, Esther, Garcia, Francisca, Jo, Hanjoong, Fang, Yun, Yang, Kai-Chien
Publicado 2022

Hidden RNA pairings counteract the “first-come, first-served” splicing principle to drive stochastic choice in Dscam1 splice variants

por Dong, Haiyang, Xu, Bingbing, Guo, Pengjuan, Zhang, Jian, Yang, Xi, Li, Lei, Fu, Ying, Shi, Jilong, Zhang, Shixin, Zhu, Yanda, Shi, Yang, Zhou, Fengyan, Bian, Lina, You, Wendong, Shi, Feng, Yang, Xiaofeng, Huang, Jianhua, He, Haihuai, Jin, Yongfeng
Publicado 2022

Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter

por Chaptal, Vincent, Zampieri, Veronica, Wiseman, Benjamin, Orelle, Cédric, Martin, Juliette, Nguyen, Kim-Anh, Gobet, Alexia, Di Cesare, Margot, Magnard, Sandrine, Javed, Waqas, Eid, Jad, Kilburg, Arnaud, Peuchmaur, Marine, Marcoux, Julien, Monticelli, Luca, Hogbom, Martin, Schoehn, Guy, Jault, Jean-Michel, Boumendjel, Ahcène, Falson, Pierre
Publicado 2022

Skin and heart allograft rejection solely by long-lived alloreactive T(RM) cells in skin of severe combined immunodeficient mice

por Tian, Qianchuan, Zhang, Zhaoqi, Tan, Liang, Yang, Fan, Xu, Yanan, Guo, Yinan, Wei, Dong, Wu, Changhong, Cao, Peng, Ji, Jiawei, Wang, Wei, Xie, Xubiao, Zhao, Yong
Publicado 2022

Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq–guided combination with sapanisertib

por Lim, Chaemin, Dismuke, Taylor, Malawsky, Daniel, Ramsey, Jacob D., Hwang, Duhyeong, Godfrey, Virginia L., Kabanov, Alexander V., Gershon, Timothy R., Sokolsky-Papkov, Marina
Publicado 2022

SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics

por Wikle, Nathan B., Tran, Thu Nguyen-Anh, Gentilesco, Bethany, Leighow, Scott M., Albert, Emmy, Strong, Emily R., Brinda, Karel, Inam, Haider, Yang, Fuhan, Hossain, Sajid, Chan, Philip, Hanage, William P., Messick, Maria, Pritchard, Justin R., Hanks, Ephraim M., Boni, Maciej F.
Publicado 2022

Association Between Tobacco Retailer Density and Smoking Among Adults With Diabetes and Serious Mental Illness in New York State

por Alharthy, Amani, Hosler, Akiko S., Leckman-Westin, Emily, Kammer, Jamie R.
Publicado 2022

Multi-principal elemental intermetallic nanoparticles synthesized via a disorder-to-order transition

por Cui, Mingjin, Yang, Chunpeng, Hwang, Sooyeon, Yang, Menghao, Overa, Sean, Dong, Qi, Yao, Yonggang, Brozena, Alexandra H., Cullen, David A., Chi, Miaofang, Blum, Thomas F., Morris, David, Finfrock, Zou, Wang, Xizheng, Zhang, Peng, Goncharov, Vitaliy G., Guo, Xiaofeng, Luo, Jian, Mo, Yifei, Jiao, Feng, Hu, Liangbing
Publicado 2022

C1q deletion exacerbates stress-induced learned helplessness behavior and induces neuroinflammation in mice

por Madeshiya, Amit Kumar, Whitehead, Carl, Tripathi, Ashutosh, Pillai, Anilkumar
Publicado 2022

Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells

por Das, Jugal Kishore, Ren, Yijie, Kumar, Anil, Peng, Hao-Yun, Wang, Liqing, Xiong, Xiaofang, Alaniz, Robert C., de Figueiredo, Paul, Ren, Xingcong, Liu, Xiaoqi, Ryazonov, Alexey G., Yang, Jin-Ming, Song, Jianxun
Publicado 2022

Species delimitation and mitonuclear discordance within a species complex of biting midges

por Shults, Phillip, Hopken, Matthew, Eyer, Pierre-Andre, Blumenfeld, Alexander, Mateos, Mariana, Cohnstaedt, Lee W., Vargo, Edward L.
Publicado 2022

Medication Cost-Savings and Utilization of Generic Inhaled Corticosteroid (ICS) and Long-Acting Beta-Agonist (LABA) Drug Products in the USA

por Wang, Zhong, Ahluwalia, Sharon K., Newman, Bryan, Dhapare, Sneha, Zhao, Liang, Luke, Markham C.
Publicado 2022

Temporal dynamics of the neural representation of hue and luminance polarity

por Hermann, Katherine L., Singh, Shridhar R., Rosenthal, Isabelle A., Pantazis, Dimitrios, Conway, Bevil R.
Publicado 2022

Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non–small cell lung cancer

por Huang, Qingyuan, Li, Fei, Hu, Hai, Fang, Zhaoyuan, Gao, Zhendong, Xia, Guozhan, Ng, Wai-Lung, Khodadadi-Jamayran, Alireza, Chen, Ting, Deng, Jiehui, Zhang, Hua, Almonte, Christina, Labbe, Kristen, Han, Han, Geng, Ke, Tang, Sittinon, Freeman, Gordon J., Li, Yuan, Chen, Haiquan, Wong, Kwok-Kin
Publicado 2022

P2X4 and P2X7 are essential players in basal T cell activity and Ca(2+) signaling milliseconds after T cell activation

por Brock, Valerie J., Wolf, Insa M. A., Er-Lukowiak, Marco, Lory, Niels, Stähler, Tobias, Woelk, Lena-Marie, Mittrücker, Hans-Willi, Müller, Christa E., Koch-Nolte, Friedrich, Rissiek, Björn, Werner, René, Guse, Andreas H., Diercks, Björn-Philipp
Publicado 2022