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  1. 2661
    “…PD-L1 gene expression was compared to the mutational status of each gene separately by using a Mann-Whitney U-test and a Receiver Operating Characteristic test. …”
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    Mutations Defining Patient Cohorts With Elevated PD-L1 Expression in Gastric Cancer
  2. 2662
    “…M30 levels of >200 U/L reveal a sensitivity for predicting cirrhosis of 84.5% with a negative predictive value of 73.5%. …”
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    Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis
  3. 2663
    “…We propose that MEDI-579 acts by directly competing with proteases for RCL binding and as such is able to modulate the interaction of PAI-1 with tPA and uPA in a way not previously described for a human PAI-1 inhibitor.…”
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    Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
  4. 2664
    “…Currently, urinary procollagen type III amino-terminal propeptide (uPIIINP) is a renal fibrosis biomarker in humans. Moreover, PIIINP is increasingly applied for identification of fibrosis in various organs in animals. …”
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    Renal shear wave elastography and urinary procollagen type III amino-terminal propeptide (uPIIINP) in feline chronic kidney disease
  5. 2665
    “…The critical value of plasma TrxR activity levels for diagnosis of NSCLC was set at 10.18 U/ml, with a sensitivity of 71.6% and a specificity of 91.9%. …”
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    Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study
  6. 2666
    por Hein, Anke, Brenner, Sarah, Knoop, Volker
    Publicado 2019
    “…Here, we report on alternative evolutionary pathways for DOT4 addressing rpoC1eU488SL, a chloroplast editing site in the RNA polymerase β′ subunit mRNA. …”
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    Multifarious Evolutionary Pathways of a Nuclear RNA Editing Factor: Disjunctions in Coevolution of DOT4 and Its Chloroplast Target rpoC1eU488SL
  7. 2667
    “…Results showed that milk production losses were expected to accelerate across the U.S. at a mean rate of 174±7 kg/cow/decade, with the fastest rate in the Southeast region. …”
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    Projected heat stress challenges and abatement opportunities for U.S. milk production
  8. 2668
    “…Phosphorylation of ERK and expression of Snail were blocked by Dsf treatment. Like Dsf, U0126 had a similar effect on EMT of CAL27 and SCC25. …”
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    Disulfiram inhibits epithelial–mesenchymal transition through TGFβ–ERK–Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis
  9. 2669
    “…A significantly higher Penh ratio and IgE level were detected in the serum, bronchoalveolar lavage fluid (BALF) and the supernatant of a lymphocyte culture from mice treated with HBoV-VP1u or B19V-VP1u than in a lymphocyte culture from OVA-sensitized mice. …”
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    The effects of human parvovirus VP1 unique region in a mouse model of allergic asthma
  10. 2670
    “…The performance of uTWEAK as a predictor for treatment response was compared with clinically used biomarkers for patients with LN. …”
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    Urine TWEAK level as a biomarker for early response to treatment in active lupus nephritis: a prospective multicentre study
  11. 2671
    “…The similar resistance of pink bollworm to Cry1Ac in laboratory- and field-selected insects from China, India and the U.S. provides a basis for developing international resistance management practices.…”
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    Transposon insertion causes cadherin mis-splicing and confers resistance to Bt cotton in pink bollworm from China
  12. 2672
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    Improving risk stratification in heart failure with preserved ejection fraction by combining two validated risk scores
  13. 2673
    “…Since MSCs have been shown to exert immunomodulatory effects on the immune cells, especially DCs, this study was performed to investigate the capability of MSCs to modulate the frequency, maturation state, and phenotype of uterine DCs (uDCs) as a potential mechanism for the improvement of pregnancy outcome. …”
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    Uterine Dendritic Cells Modulation by Mesenchymal Stem Cells Provides A Protective Microenvironment at The Feto-Maternal Interface: Improved Pregnancy Outcome in Abortion-Prone Mice
  14. 2674
    “…Cell apoptosis and proliferation were detected by flow cytometry and EdU proliferation assay. A luciferase reporter of DUSP4 3'-UTR was used for validation as a target gene of miR-1226-3p. …”
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    miR-1226-3p Promotes Sorafenib Sensitivity of Hepatocellular Carcinoma via Downregulation of DUSP4 Expression
  15. 2675
    “…The Me7 locus was delimited between two markers G21U3 and G43U3 covering a physical interval of approximately 394.7 kb on the CM334 chromosome P9. …”
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    Physical Localization of the Root-Knot Nematode (Meloidogyne incognita) Resistance Locus Me7 in Pepper (Capsicum annuum)
  16. 2676
    “…The cut-off value was 72 U/L with a sensitivity of 0.764 and a specificity of 0.468. …”
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    Prognostic impact of alkaline phosphatase for in-hospital mortality in patients with acute coronary syndrome: a prospective cohort study in China
  17. 2677
    “…Most of the subjects were White, since patients were drawn from the U.S. Midwest, a predominantly White population.…”
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    Patient preferences of chemotherapy treatment options and tolerance of chemotherapy side effects in advanced stage lung cancer
  18. 2678
    “…BACKGROUND: The National Early Warning Score (NEWS/NEWS 2) has been adopted across the National Health Service (NHS) in the U.K. as a method of escalating care for deteriorating patients. …”
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    Using the National Early Warning Score (NEWS/NEWS 2) in different Intensive Care Units (ICUs) to predict the discharge location of patients
  19. 2679
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    Hemoglobin S and Glucose-6-Phosphate Dehydrogenase Deficiency Coinheritance in AS and SS Individuals in Malaria-Endemic Region: A Study in Calabar, Nigeria
  20. 2680
    “…METHODS: A microsimulation model, informed by clinical outcomes from the subgroup of patients using basal–bolus insulin therapy in DEVOTE (NCT01959529) and by the UKPDS Outcomes Model 2 risk equations, was used to model direct costs (2018 GBP) and effectiveness outcomes [quality-adjusted life years (QALYs)] with degludec versus glargine U100 over a 40-year time horizon. The model captured the development of eight diabetes-related complications, death, severe hypoglycemia and insulin dosing. …”
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    Long-term Cost-effectiveness of Insulin Degludec Versus Insulin Glargine U100 in the UK: Evidence from the Basal-bolus Subgroup of the DEVOTE Trial (DEVOTE 16)
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