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  1. 2821
    “…Importantly, we confirmed the role of the FBXO34/hnRNP U axis in the primary CD4(+) T lymphocyte model, and detected differences in hnRNP U expression levels in samples from patients treated with antiretroviral therapy (ART) and healthy people, which further suggests that the FBXO34/hnRNP U axis is a new pathway involved in HIV-1 latency. These results provide mechanistic insights into the critical role of ubiquitination and hnRNP U in HIV-1 latency. …”
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    Online Artículo Texto
    FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation
  2. 2822
    “…By contrast, a dysferlin variant with GCaMP6f(u) in place of its C2A domain accumulated at triad junctions, like wild type dysferlin, and suppressed all abnormal Ca(2+) signaling. GCaMP6f(u) introduced as a Venus chimera did not accumulate at junctions and failed to suppress abnormal Ca(2+) signaling. …”
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    Online Artículo Texto
    Elevated Ca(2+) at the triad junction underlies dysregulation of Ca(2+) signaling in dysferlin-null skeletal muscle
  3. 2823
    “…Our findings suggested a protective effect of piroxicam, but not dexamethasone, on PBMCs against inhibitory mechanisms of two glioblastoma cell lines, U-87 and A-172 cells.…”
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    Online Artículo Texto
    Protective potential of piroxicam on human peripheral blood mononuclear cells against the suppressive capacity of glioblastoma cell lines
  4. 2824
    “…Our study demonstrated promising diagnostic accuracy for the uTERTpm as a non-invasive urinary biomarker to detect, in particular, primary BC in this population.…”
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    Online Artículo Texto
    TERT Promoter Mutations as Simple and Non-Invasive Urinary Biomarkers for the Detection of Urothelial Bladder Cancer in a High-Risk Region
  5. 2825
    “…Semantic segmentation was performed using basic 3D U-Net and a cascaded 3D U-Net. A stress test was performed using different sets of condylar images as the training, validation, and test datasets. …”
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    Online Artículo Texto
    Fully automated condyle segmentation using 3D convolutional neural networks
  6. 2826
    “…Approximately 39.7% of CBCS and 29.3% of TCGA breast tumors had this unsupervised high-HRD (U-HRD) profile. A supervised HRD classifier (S-HRD) trained on TCGA had 84% sensitivity and 73% specificity to detect HRD-high samples. …”
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    Online Artículo Texto
    RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer
  7. 2827
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    Online Artículo Texto
    Quantitative computed tomography predicts outcomes in idiopathic pulmonary fibrosis
  8. 2828
    “…Furthermore, lysosomal membrane stabilization using U18666A, a cholesterol transporter Niemann-Pick disease C1 (NPC1) inhibitor, suppressed LMP as well as LDCD in wild-type TP53, but not in TP53-KO, A549 cells. …”
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    Online Artículo Texto
    p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs
  9. 2829
    “…The recombinant enzyme showed the highest activity (28,160 U/mg) against a C10 substrate at pH 9.0 and 47°C, and was stable at temperatures ≤50°C and pH 8.0–11.0. …”
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    Online Artículo Texto
    Characterization of a novel thermostable alkaline lipase derived from a compost metagenomic library and its potential application in the detergent industry
  10. 2830
    por Guo, Rong, Yu, Xiang, Gregory, Brian D.
    Publicado 2023
    “…In total, our findings provide the identification of CTRD and actively translating uORFs across a broad collection of plants and provide novel insights into the important sequence features associated with these collections of mRNAs and regulatory elements, respectively.…”
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    Online Artículo Texto
    The identification of conserved sequence features of co‐translationally decayed mRNAs and upstream open reading frames in angiosperm transcriptomes
  11. 2831
    “…Subsequent analysis was conducted to test the Overall Technical Efficiency (OTE), the Pure Technical Efficiency (PTE), the Scale Efficiency (SE), and the Return to Scale with the type of health facilities and geographical areas using a Mann-Whitney U-test and a chi-square test. RESULTS: The mean scores of OTE, PTE, and SE were 0.508 (±0.207), 0.721 (±0.185), and 0.700 (±0.200), respectively. …”
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    Online Artículo Texto
    Data envelopment analysis for ambulance services of different service providers in urban and rural areas in Ministry of Health Malaysia
  12. 2832
    “…In this study, a whole-genome survey of the MADS-box gene family was performed for the first time in the triangle of U species, and a total of 1430 MADS-box genes were identified. …”
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    Online Artículo Texto
    Systematic analysis of MADS-box gene family in the U’s triangle species and targeted mutagenesis of BnaAG homologs to explore its role in floral organ identity in Brassica napus
  13. 2833
    “…The Mann Whitney U test demonstrated a statistically significant higher calcium score in the smoking group (mean = 4.8, SD 3.7), versus the non-smoking group, (mean = 1.8, SD 1.9) (U = 701.5, p < 0.05). …”
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    Online Artículo Texto
    Can smoking cause impotence? a radiological retrospective cohort study comparing internal pudendal artery calcification on CT in male smokers versus non-smokers
  14. 2834
    “…Conclusion: The data indicate that PseU-ST is a very competitive prediction model for identifying RNA Ψ sites in H. sapiens, M. musculus, and S. cerevisiae. …”
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    Online Artículo Texto
    PseU-ST: A new stacked ensemble-learning method for identifying RNA pseudouridine sites
  15. 2835
    “…The development of a comprehensive scorecard with key sexual health indicators has been proposed by other entities (e.g., Public Health England, World Health Organization), but such an attempt has not been made in the U.S. METHODS: A review of national U.S. surveys and surveillance systems with items related to sexual health was conducted for years 2010–2022 to develop an inventory of existing data that yield national estimates for potential indicators of sexual health. …”
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    Online Artículo Texto
    Sexual health indicators for the United States: Measuring progress and documenting public health needs
  16. 2836
    “…OBJECTIVE: To define the diagnostic and prognostic value of Bcl-2 loss in uLMS through a systematic review and meta-analysis. METHODS: Electronic databases were searched from their inception to May 2020 for all studies assessing the diagnostic and prognostic value of Bcl-2 loss of immunohistochemical expression in uLMS. …”
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    Online Artículo Texto
    Diagnostic and prognostic value of Bcl-2 in uterine leiomyosarcoma
  17. 2837
    “…The Mann-Whitney U-test showed a significant difference in PCT values in sepsis and non-sepsis patients between 12 and 24 hours, including post-hoc analysis (p <0.05). …”
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    Online Artículo Texto
    IBM WATSON Trauma Pathway Explorer© as a Predictor for Sepsis after Polytrauma - Is Procalcitonin Useful for Identifying Septic Polytrauma Patients?
  18. 2838
    “…The purpose of this study is to determine the frequency of alleles conferring resistance to Vip3Aa in H. zea in the mid-south region of the U.S. Using a modified F(2) screen method, we found the major resistance allele frequency for Vip3Aa in H. zea collected from four southern states during 2019–2020 was 0.0155, suggesting that the frequency of Vip3Aa resistance alleles in H. zea is not rare in the field. …”
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    Online Artículo Texto
    Resistance Allele Frequency of Helicoverpa zea to Vip3Aa Bacillus thuringiensis Protein in the Southeastern U.S.
  19. 2839
    “…CONCLUSION: IL‐1 inhibition with rilonacept did not improve ColdU, but demonstrated a good safety profile. CLINICAL TRIAL REGISTRATION: EudraCT number: 2012‐005726‐30. …”
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    Online Artículo Texto
    Inhibition of interleukin‐1 with rilonacept is not effective in cold urticaria—Results of a randomized, placebo‐controlled study
  20. 2840
    por Ahmed, Z., Apresyan, A., Artuso, M., Barry, P., Bielejec, E., Blaszczyk, F., Bose, T., Braga, D., Charlebois, S.A., Chatterjee, A., Chavarria, A., Cho, H.-M., Dalla Torre, S., Demarteau, M., Denisov, D., Diefenthaler, M., Dragone, A., Fahim, F., Gee, C., Habib, S., Haller, G., Hogan, J., Jones, B.J.P., Garcia-Sciveres, M., Giacomini, G., Gilmore, K., Giovanetti, G.K., Glenzinski, D., Gleyzer, S., Goldan, A.H., Gollapinni, S., Grace, C., Guenette, R., Gutsche, O., Heintz, U., Hertel, S.A., Hutzler, N.R., Kolkowitz, S., Kovachy, T., Leonard, F., Lipton, R., Liu, M., Low, J.F., Madigan, P., Malik, S., Mates, J., Mei, Y., Merkel, P., Mohayai, T., Nomerotski, A., Oliveri, E., Palladino, K., Pantic, E., Para, A., Perez, K., Pyle, M., Riedler, P., Ropelewski, L., Rusack, R., Schleier-Smith, M., Shipsey, I., Scholberg, K., Schumm, B.A., Slosar, A., Smith, W., Surrow, B., Sushkov, A.O., Suzuki, A., Szydagis, M., Temples, D., Thom, J., Titov, M., Tvrznikova, L., Usai, E., Van Berg, R., Velan, V., Whittington, D.W., Winslow, L., Wongjirad, T., Xia, Q., Xie, J., You, Z.F., Zani, A., Zhang, J., Zhu, R.Y.
    Publicado 2019
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    New Technologies for Discovery
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