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  1. 3281
    “…BACKGROUND: This study aimed to evaluate safety and efficacy of programmed death-1 (PD-1) inhibitor sintilimab plus tyrosine kinase inhibitors (TKI) in a real-word cohort of patients with unresectable hepatocellular carcinoma (uHCC). METHODS: A total of 60 patients treated with sintilimab plus TKI between February 2019 and December 2019 were enrolled. …”
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    Immune checkpoint inhibitor plus tyrosine kinase inhibitor for unresectable hepatocellular carcinoma in the real world
  2. 3282
    “…Subsections were rated on a 6-point Likert scale (1 = completely agree, 6 = completely disagree), the results of the survey were compared using the Mann-Whitney-U-Test with a p < 0.05 being the level of significance. …”
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    Design and preliminary evaluation of a newly designed patient-friendly discharge letter – a randomized, controlled participant-blind trial
  3. 3283
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    Analysis of Road Traffic Accident Fatalities in Karachi, Pakistan: An Autopsy-Based Study
  4. 3284
    “…Using stable GliPR1 knockdown, polyclonal shGliPR1-transduced U87-MG, A172, and U343-MG cells consistently showed decreased clonogenic survival and induced apoptosis (higher proportion of early apoptotic cells) compared to control shLuc-transduced cells. …”
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    GliPR1 knockdown by RNA interference exerts anti‐glioma effects in vitro and in vivo
  5. 3285
    “…AoU age-adjusted HTN prevalence was 27.9% using 3 groups compared to 29.6% in NHANES. The AoU cohort is a growing source of diverse longitudinal data to study hypertension nationwide and develop precision rule-based algorithms for use in hypertension treatment and prevention research. …”
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    Hypertension prevalence in the All of Us Research Program among groups traditionally underrepresented in medical research
  6. 3286
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    Incidence and risk factors of oral feeding intolerance in acute pancreatitis: Results from an international, multicenter, prospective cohort study
  7. 3287
    “…Median GH levels increased from 3.67 mU/L with a maximal median change of 94.66 [IQR 56.5; 110.96] mU/L, p < 0.001. …”
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    Effects of oral macimorelin on copeptin and anterior pituitary hormones in healthy volunteers
  8. 3288
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    Effect of land-use change along altitudinal gradients on soil micronutrients in the mountain ecosystem of Indian (Eastern) Himalaya
  9. 3289
    “…BACKGROUND: Transgender women in the United States (U.S.) experience a disproportionate burden of HIV infection and challenges to engagement in HIV prevention and care. …”
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    U.S. transgender women’s preferences for microeconomic interventions to address structural determinants of HIV vulnerability: a qualitative assessment
  10. 3290
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    First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland
  11. 3291
    “…BACKGROUND: Usual vulvar intraepithelial neoplasia (uVIN) is a premalignancy caused by persistent infection with high-risk types of human papillomavirus (HPV), mainly type 16. …”
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    HPV-16 E6/E7 DNA tattoo vaccination using genetically optimized vaccines elicit clinical and immunological responses in patients with usual vulvar intraepithelial neoplasia (uVIN): a phase I/II clinical trial
  12. 3292
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    Demonstration of reduced neoclassical energy transport in Wendelstein 7-X
  13. 3293
    “…There is still a lack of identified pathological factors associated with disease recurrence that could help in making treatment decisions. Neuromedin U (NMU) is a secretory neuropeptide that was first isolated from the porcine spinal cord, and it has emerged as a novel factor involved in the tumorigenesis and/or metastasis of many types of cancers. …”
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    Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor
  14. 3294
    por Halder, Sebok K., Milner, Richard
    Publicado 2021
    “…RESULTS: The following was observed: (1) most endothelial proliferation and extravascular fibrinogen leak occurred in capillaries and to a lesser degree in venules, (2) much to our surprise, endothelial proliferation and extravascular fibrinogen leak never colocalized, (3) interestingly however, endothelial proliferation was strongly associated with an intravascular fibrinogen staining pattern not seen in stable blood vessels, (4) DiI perfusion studies revealed that angiogenic vessels were adequately perfused, suggesting that fibrinogen retention in angiogenic vessels is not due to temporary closure of the vessel, but more likely because fibrinogen is retained within the vessel wall, (5) bromodeoxyuridine (BrdU) labelling as a means to more permanently label proliferating endothelial cells, confirmed lack of any connection between endothelial proliferation and extravascular fibrinogen leak, while (6) in contrast, proliferating microglia were detected within extravascular leaks. …”
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    The impact of chronic mild hypoxia on cerebrovascular remodelling; uncoupling of angiogenesis and vascular breakdown
  15. 3295
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    The effects of Levilactobacillus brevis on the physiological parameters and gut microbiota composition of rats subjected to desynchronosis
  16. 3296
    “…CONCLUSION: Hospitalized COVID-19 patients in the U.S. have a high prevalence of myocardial injury, which was associated with poorer survival and outcomes. …”
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    Myocardial injury in hospitalized COVID-19 patients: a retrospective study, systematic review, and meta-analysis
  17. 3297
    “…METHODS: We collected EVs in the culture medium of three classic glioblastoma cell lines, U87 and A172 (male cell lines), and LN229 (female cell line). …”
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    Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway
  18. 3298
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    A qualitative study of an undergraduate online emergency medicine education program at a teaching Hospital in Kampala, Uganda
  19. 3299
    “…INTRODUCTION: There are currently no approved treatments solely for unclassifiable interstitial lung disease (uILD); however, a recent trial showed this population can benefit from pirfenidone. …”
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    Pirfenidone in Unclassifiable Interstitial Lung Disease: A Subgroup Analysis by Concomitant Mycophenolate Mofetil and/or Previous Corticosteroid Use
  20. 3300
    “…Statistics were performed by Fisher’s exact test and Mann Whitney U test. RESULTS: A total of 426 PD were performed at the Vivantes Humboldt-hospital. …”
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    The clinical impact of preoperative biliary drainage on isolated infectious complications (iiC) after pancreatic head resection—a retrospective study
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