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1441por Soto-Acosta, Ruben, Edwards, Tiffany C., Dreis, Christine D., Krishna, Venkatramana D., Cheeran, Maxim C-J., Qiu, Li, Xie, Jiashu, Bonnac, Laurent F., Geraghty, Robert J.“…The 6MMPr/T-1105 combination increased the C-U and G-A mutation frequency compared to treatment with T-1105 or 6MMPr alone. …”
Publicado 2021
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1442por Hu, Sheng, Lan, Tian, Wang, Silin, Su, Lang, Zou, Sheng, Ye, Jiayue, Zhang, Yang, Zhang, Deyuan, Guo, Qiang, Zhang, Wenxiong, Yu, Dongliang, Xu, Jianjun, Wei, Yiping, Peng, Jinhua“…The smooth curves fitted were all inverted-U shaped. Below a cutoff value of 92 mmol/L, increase in serum chloride level was associated with increase in AAC-24; however, above that cutoff, increase in serum chloride level was associated with decrease in AAC-24. …”
Publicado 2022
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1443por Ahmed, Ishaq, Bandpei, Mohammad Ali Mohseni, Gilani, Syed Amir, Ahmad, Ashfaq, Zaidi, Faryal“…RESULTS: The results of the Wilcoxon signed-rank test score as well as Mann–Whitney U test indicated a statistically significant difference in values (p < 0.05 in all instances) within the groups and between the groups, respectively. …”
Publicado 2022
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1444por Zhong, Yi, Xu, Jinhui, Zhao, Xinyu, Qu, Tongfei, Guan, Chen, Hou, Chengzong, Tang, Xuexi, Wang, Ying“…Previous study confirmed that U. prolifera displayed a wide variety of physiological responses characterized as acclimation to UVBR, while the response mechanisms against low-dose and short-term radiation (LDSTR) are not clear. …”
Publicado 2022
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1445por Tucker, Larry A.“…The main goal of this investigation was to evaluate the relationships between several macronutrients and insulin resistance in 5665 non-diabetic U.S. adults. A secondary objective was to determine the extent to which the associations were influenced by multiple potential confounding variables. …”
Publicado 2022
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1446“…. @ 5 K) than the LNMO nanorods (M(S) = 5.68 μ(B)/f.u.) due to a lower structural disorder in the LNMO nanorods. …”
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1447por Baldini, Enke, Presutti, Dario, Favoriti, Pasqualino, Santini, Simonetta, Papoff, Giuliana, Tuccilli, Chiara, Carletti, Raffaella, Di Gioia, Cira, Lori, Eleonora, Ferent, Iulia Catalina, Gagliardi, Federica, Catania, Antonio, Pironi, Daniele, Tripodi, Domenico, D’Andrea, Vito, Sorrenti, Salvatore, Ruberti, Giovina, Ulisse, Salvatore“…In recent years, several uPA inhibitors were found to have anticancer effects in preclinical studies and in some phase II clinical trials, which prompted us to evaluate uPA as a potential therapeutic target for the treatment of patients affected by the most aggressive form of thyroid cancer, the anaplastic thyroid carcinoma (ATC). …”
Publicado 2022
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1448por Dreymann, Nico, Wuensche, Julia, Sabrowski, Wiebke, Moeller, Anja, Czepluch, Denise, Vu Van, Dana, Fuessel, Susanne, Menger, Marcus M.“…Here, uPAapt-02-FR showed highly affine binding with a K(D) of 0.7 nM for HMW-uPA and 21 nM for LMW-uPA and was also able to bind to pro-uPA with a K(D) of 14 nM. Furthermore, no cross-reactivity to mouse uPA or tissue-type plasminogen activator (tPA) was measured, demonstrating high specificity. …”
Publicado 2022
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1449“…BaAXE was active on 4-nitrophenyl acetate, reporting a specific activity of 78.12 U/mg and a Km value of 0.43 mM. The enzyme showed optimal activity at 40 °C and pH 8 and showed high thermal stability, retaining over 40% activity after 2 h of incubation from 40 °C to 100 °C. …”
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1450por Marek-Jozefowicz, Luiza, Lemanowicz, Adam, Grochocka, Małgorzata, Wróblewska, Monika, Białczyk, Katarzyna, Piec, Katarzyna, Kozera, Grzegorz M., Serafin, Zbigniew, Czajkowski, Rafał, Borkowska, Alina“…The differences between groups were evaluated using a Student’s t-test and a Mann-Whitney U test, and a Pearson correlation analysis was also performed. …”
Publicado 2022
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1451por Sun, Yin, Tang, Haotian, Wang, Xiaoyan, Feng, Fang, Fan, Tiantian, Zhao, Dongmei, Xiong, Bing, Xie, Hua, Liu, Tongchao“…Meanwhile, compound 15y exhibited a micromolar antiproliferation effect on A172, U87MG, A375, A2058, and Panc0504 cell lines. Together, current results provided a promising TBK1 inhibitor 15y as lead compound for immune- and cancer-related drug discovery.…”
Publicado 2022
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1452“…Methods: This cross-sectional descriptive study recruited a nationally representative, non-probability sample of parents or guardians (n = 2100) of children attending grades K-12 in the United States (U.S.) through a 58-item web-based survey. The univariate, bivariate, and multivariate statistical tests were used to analyze the data. …”
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1453por Abedin, Yasmin, Gabrilovich, Sofia, Alpert, Emily, Rego, Erica, Begum, Salma, Zhao, Qingshi, Heller, Debra, Einstein, Mark H., Douglas, Nataki C.“…Uterine leiomyosarcoma (uLMS) is a rare and aggressive cancer with few effective therapeutics. …”
Publicado 2022
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1454por Sourimant, Julien, Lieber, Carolin M., Aggarwal, Megha, Cox, Robert M., Wolf, Josef D., Yoon, Jeong-Joong, Toots, Mart, Ye, Chengin, Sticher, Zachary, Kolykhalov, Alexander A., Martinez-Sobrido, Luis, Bluemling, Gregory R., Natchus, Michael G., Painter, George R., Plemper, Richard K.“…We describe 4′-fluorouridine (4′-FlU, EIDD-2749), a ribonucleoside analog that inhibits RSV, related RNA viruses, and SARS-CoV-2 with high selectivity index in cells and human airway epithelia organoids. …”
Publicado 2021
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1455“…In the re-expression strain pgalU, these inhibited pathways were restored; moreover, the pgalU cells showed a strengthened cell wall and capsule, which enhanced their resistance to adverse environments. …”
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1456por Vera-Palacios, Antonio L., Sacoto-Torres, Juan D., Hernández-Altamirano, Josselin A., Moreno, Andres, Peñuela-Mora, Maria C., Salazar-Valenzuela, David, Mogollón, Noroska G. S., Almeida, José R.“…Our data support the biomedical value of U. sagittifolia as a source of natural enzyme inhibitors able to neutralize catalytically active B. atrox venom toxins and their toxic effects.…”
Publicado 2022
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1458por Magnuson, Jason T., Fuller, Neil, Huff Hartz, Kara E., Anzalone, Sara, Whitledge, Gregory W., Acuña, Shawn, Lydy, Michael J., Schlenk, Daniel“…Chinook were assessed for maximum swimming performance (U(max)) using a short-duration constant acceleration test and biochemical responses related to energetic processes (glucose levels) and liver health (aspartate aminotransferase (AST) activity). …”
Publicado 2022
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1459“…Using Hausdorff distance separately as a feature parameter, the algorithm achieved excellent performance, with precision, recall, and F1 scores reaching 0.9423, 0.98, and 0.9608, respectively. Using IoU separately as a feature parameter, the algorithm achieved a higher overall recognition rate, with precision, recall, and F1 scores of 1, 0.96, and 0.9796, respectively. …”
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1460“…Our results prove that the functional PLGA nanoparticle loaded with the ICG@uPA offers a novel option for effective and safe thrombolytic treatment.…”
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