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  1. 1441
  2. 1442
    “…The smooth curves fitted were all inverted-U shaped. Below a cutoff value of 92 mmol/L, increase in serum chloride level was associated with increase in AAC-24; however, above that cutoff, increase in serum chloride level was associated with decrease in AAC-24. …”
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  3. 1443
    “…RESULTS: The results of the Wilcoxon signed-rank test score as well as Mann–Whitney U test indicated a statistically significant difference in values (p < 0.05 in all instances) within the groups and between the groups, respectively. …”
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  4. 1444
    “…Previous study confirmed that U. prolifera displayed a wide variety of physiological responses characterized as acclimation to UVBR, while the response mechanisms against low-dose and short-term radiation (LDSTR) are not clear. …”
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  5. 1445
    por Tucker, Larry A.
    Publicado 2022
    “…The main goal of this investigation was to evaluate the relationships between several macronutrients and insulin resistance in 5665 non-diabetic U.S. adults. A secondary objective was to determine the extent to which the associations were influenced by multiple potential confounding variables. …”
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  6. 1446
    “…. @ 5 K) than the LNMO nanorods (M(S) = 5.68 μ(B)/f.u.) due to a lower structural disorder in the LNMO nanorods. …”
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  7. 1447
    “…In recent years, several uPA inhibitors were found to have anticancer effects in preclinical studies and in some phase II clinical trials, which prompted us to evaluate uPA as a potential therapeutic target for the treatment of patients affected by the most aggressive form of thyroid cancer, the anaplastic thyroid carcinoma (ATC). …”
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  8. 1448
    “…Here, uPAapt-02-FR showed highly affine binding with a K(D) of 0.7 nM for HMW-uPA and 21 nM for LMW-uPA and was also able to bind to pro-uPA with a K(D) of 14 nM. Furthermore, no cross-reactivity to mouse uPA or tissue-type plasminogen activator (tPA) was measured, demonstrating high specificity. …”
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  9. 1449
    por Madubuike, Henry, Ferry, Natalie
    Publicado 2022
    “…BaAXE was active on 4-nitrophenyl acetate, reporting a specific activity of 78.12 U/mg and a Km value of 0.43 mM. The enzyme showed optimal activity at 40 °C and pH 8 and showed high thermal stability, retaining over 40% activity after 2 h of incubation from 40 °C to 100 °C. …”
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  10. 1450
  11. 1451
    “…Meanwhile, compound 15y exhibited a micromolar antiproliferation effect on A172, U87MG, A375, A2058, and Panc0504 cell lines. Together, current results provided a promising TBK1 inhibitor 15y as lead compound for immune- and cancer-related drug discovery.…”
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  12. 1452
    “…Methods: This cross-sectional descriptive study recruited a nationally representative, non-probability sample of parents or guardians (n = 2100) of children attending grades K-12 in the United States (U.S.) through a 58-item web-based survey. The univariate, bivariate, and multivariate statistical tests were used to analyze the data. …”
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  13. 1453
  14. 1454
  15. 1455
    “…In the re-expression strain pgalU, these inhibited pathways were restored; moreover, the pgalU cells showed a strengthened cell wall and capsule, which enhanced their resistance to adverse environments. …”
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  16. 1456
  17. 1457
  18. 1458
    “…Chinook were assessed for maximum swimming performance (U(max)) using a short-duration constant acceleration test and biochemical responses related to energetic processes (glucose levels) and liver health (aspartate aminotransferase (AST) activity). …”
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  19. 1459
    “…Using Hausdorff distance separately as a feature parameter, the algorithm achieved excellent performance, with precision, recall, and F1 scores reaching 0.9423, 0.98, and 0.9608, respectively. Using IoU separately as a feature parameter, the algorithm achieved a higher overall recognition rate, with precision, recall, and F1 scores of 1, 0.96, and 0.9796, respectively. …”
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  20. 1460
    “…Our results prove that the functional PLGA nanoparticle loaded with the ICG@uPA offers a novel option for effective and safe thrombolytic treatment.…”
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