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  1. 1541
    Publicado 1994
    “…New Zealand White (NZW) mice, with identical class II H-2u genes (I-A and I-E), carry an 8.8-kb deletion in their TCR beta chain locus encompassing D beta 2 and J beta 2 gene segments. …”
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    Holes in the T cell repertoire to myelin basic protein owing to the absence of the D beta 2-J beta 2 gene cluster: implications for T cell receptor recognition and autoimmunity
  2. 1542
    “…The results demonstrate that competition between two I-A(u) binding registers, a low affinity register defined by MBPAc1–11 and a high affinity register defined by MBP5–16, prevents most of the NH(2)-terminal naturally processed peptides from binding in the MBPAc1–11 register. …”
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    Competition Between Two MHC Binding Registers in a Single Peptide Processed from Myelin Basic Protein Influences Tolerance and Susceptibility to Autoimmunity
  3. 1543
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    Response to endocrine manipulation and oestrogen receptor concentration in large operable primary breast cancer.
  4. 1544
    “…Plasmin at the concentration of 25 U/l induced a 160% increase in the chemotactic migration of keratinocytes that was completely blocked by the plasmin inhibitor α(2)-antiplasmin (Serpin). …”
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    Plasmin Promotes Keratinocyte Migration and Phagocytic-killing Accompanied by Suppression of Cell Proliferation which may Facilitate Re-epithelialization of Wound Beds
  5. 1545
    “…One of these mutants, termed CycT1-U7, showed a potent dominant negative effect on Tat-dependent HIV transcription despite a remarkably low steady-state expression level. …”
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    Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat
  6. 1546
    por Mayer, H., Luley, C., Behnke, M., Wieland, H.
    Publicado 1993
    “…Twenty-two analytes were tested and compared with the Olympus A U5000 analyser. A Hitachi 747 analyser was also included in this survey in order to obtain correlation data for ISE measurements. …”
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    Analytical performance of the selective multianalyser Olympus AU 5200
  7. 1547
    “…METHODS: We investigated the existence of such a U-curve in a sample of 43,534 individuals, aged between 18–90 years, who participated in a cross-sectional study (Continuous Survey of Living Conditions) of physical and mental health in the general population of the Netherlands. …”
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    Depression and body mass index, a u-shaped association
  8. 1548
    “…The second thoracentesis obtained a pleural fluid suggestive for tuberculosis, with a predominance of lymphocytes, an elevated adenosine deaminase level (51 U/l) and a positive tuberculin skin test. Culture of pleural fragments confirmed pleural tuberculosis. …”
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    Use of anabolic-androgenic steroids masking the diagnosis of pleural tuberculosis: a case report
  9. 1549
    “…We conducted telephone interviews and focus groups in 2006 with researchers from Stanford University and a mailed survey in December 2006 to 7 research universities in the U.S. FINDINGS: A total of 16 researchers were interviewed (75% response rate), 29 participated in focus groups, and 856 responded to the survey (50% response rate). …”
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    Biomedical Scientists' Perceptions of Ethical and Social Implications: Is There a Role for Research Ethics Consultation?
  10. 1550
    “…METHODOLOGY/PRINCIPAL FINDINGS: The soluble [α(1h) (u)]-RT1.A(a) allochimeric molecule was delivered into ACI recipients of WF hearts in the presence of sub-therapeutic dose of cyclosporine (CsA). …”
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    Intragraft Selection of the T Cell Receptor Repertoire by Class I MHC Sequences in Tolerant Recipients
  11. 1551
    por Perry, M. D., Sandle, G. I.
    Publicado 2009
    “…We found that PKA activation using 50 μmol/l forskolin and 5 mmol/l 3-isobutyl-1-methylxanthine stimulated BK channels in cell-attached patches and the catalytic subunit of PKA (200 U/ml) had a similar effect in excised inside-out patches. …”
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    Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin
  12. 1552
    “…One L30-like domain is predicted to bind the target loop and the other is near an internal loop more distant from the target site where a nucleotide change (U1061 to A) also decreases methylation by Tsr. Furthermore, a predicted interaction with this internal loop by Tsr amino acid Phe-88 was confirmed by mutagenesis and RNA binding experiments. …”
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    Structure of the Thiostrepton Resistance Methyltransferase·S-Adenosyl-l-methionine Complex and Its Interaction with Ribosomal RNA
  13. 1553
    “…The D-loop:T-loop interactions include the base pairs G18:U55 and U16:U59, and a unique base triple, U20:G19:C56. The extra arm comprises of a 6-bp stem and a 4-nt loop. …”
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    Crystal structure of human selenocysteine tRNA
  14. 1554
    “…CK8, therefore, function also as a receptor for uPA on the cell surface, and the presence of anti-CK MAb may prevent the binding of uPA to a designated CK8 motif. The consequent inhibition of plasmin generation resulted in changed cell morphology, enhanced cell adhesion to fibronectin, reduced invasion potential, and an enhanced G1/S transition. …”
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    Cytokeratin 8 ectoplasmic domain binds urokinase-type plasminogen activator to breast tumor cells and modulates their adhesion, growth and invasiveness
  15. 1555
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    Validating genetic risk associations for ovarian cancer through the International Ovarian Cancer Association Consortium
  16. 1556
    “…METHODOLOGY/PRINCIPAL FINDINGS: In vitro, U87, U251, and A172 human glioma cells were infected and killed by VA7-EGFP. …”
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    Intravenously Administered Alphavirus Vector VA7 Eradicates Orthotopic Human Glioma Xenografts in Nude Mice
  17. 1557
    “…The urokinase plasminogen activator (uPA) receptor (uPAR) is a GPI-linked cell surface protein that facilitates focused plasmin proteolytic activity at the cell surface. uPAR has been detected in macrophages infiltrating the central nervous system (CNS) and soluble uPAR has been detected in the cerebrospinal fluid during a number of CNS pathologies. …”
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    Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation
  18. 1558
    “…RESULTS: Celastrol affected the proliferation of U937 in a dose-dependent way, arresting the cell cycle at G0/G1 with 400 nM doses and triggering cell death with doses above 1000 nM. …”
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    HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
  19. 1559
    “…These morphological defects were alleviated in the presence of an osmotic stabilizer suggesting that absence of septins affected the proper formation of the cell wall, which was coherent with a higher sensitivity of septin defective cells to drugs that affect cell wall construction as well as exocytosis. As U. maydis is a phytopathogen, we analyzed the role of septins in virulence and found that in spite of the described morphological defects, septin mutants were virulent in corn plants. …”
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    Septins from the Phytopathogenic Fungus Ustilago maydis Are Required for Proper Morphogenesis but Dispensable for Virulence
  20. 1560
    “…A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. …”
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    Population expansion in the North African Late Pleistocene signalled by mitochondrial DNA haplogroup U6
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