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  1. 2081
    por Ge, Rile, Yang, Peng, Wen, Bingtao
    Publicado 2021
    “…Reverse transcription quantitative-PCR was performed to detect PTPRG-AS1 expression in osteosarcoma tumor tissues and cells (U2OS, SJSA1 and Saos-2), and normal tissues and cells (hFOB1.19). …”
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    Upregulation of long-noncoding RNA PTPRG-AS1 can predict the poor prognosis and promote migration and invasion in patients with osteosarcoma
  2. 2082
    “…MiR-7-5p downregulates the expression of TAF9B in MG63 and U2OS cells. The proliferation and invasion of OS cells are inhibited after miR-7-5p mimics transfection and are promoted after miR-7-5p inhibitor transfection. …”
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    Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma
  3. 2083
    “…The SF3B complex, a multiprotein component of the U2 snRNP of the spliceosome, plays a crucial role in recognizing branch point sequence and facilitates spliceosome assembly and activation. …”
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    Overlapping roles of spliceosomal components SF3B1 and PHF5A in rice splicing regulation
  4. 2084
    “…Bioinformatics and dual-luciferase assays were used to investigate the interaction between EBLN3P and miR-323a-3p, as well as between miR-323a-3p and U2AF homology motif kinase 1 (UHMK1). Western blot was applied for detecting the expressions of the related proteins. …”
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    Long Non-coding RNA EBLN3P Regulates UHMK1 Expression by Sponging miR-323a-3p and Promotes Colorectal Cancer Progression
  5. 2085
    “…Whole exome sequencing (WES) identified a novel heterogeneous c.1876T > C (p.W626R) mutation in LRBA and four somatic mutations: ASXL1 (c.1967dupA); PTPN11 (c.226G > A), U2AF1 (c.101C > T and c.470A > G), among which ASXL1 was a high-risk marker of clonal hematopoiesis. …”
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    Whole exome sequencing reveals a novel LRBA mutation and clonal hematopoiesis in a common variable immunodeficiency patient presented with hemophagocytic lymphohistiocytosis
  6. 2086
    “…Based on density functional theory (DFT) results the 5f orbital contributions to the bonding within the metallacyclopropene U‐(η (2)‐C=C) moiety increases significantly compared to the related Th(IV) compound [η (5)‐1,2,4‐(Me(3)C)(3)C(5)H(2)](2)Th[η (2)‐C(2)Ph(2)], which also results in more covalent bonds between the [η (5)‐1,2,4‐(Me(3)C)(3)C(5)H(2)](2)U(2+) and [η (2)‐C(2)Ph(2)](2−) fragments. Although the thorium and uranium complexes are structurally closely related, different reaction patterns are therefore observed. …”
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    Uranium versus Thorium: Synthesis and Reactivity of [η (5)‐1,2,4‐(Me(3)C)(3)C(5)H(2)](2)U[η (2)‐C(2)Ph(2)]
  7. 2087
    “…Furthermore, the analysis of cultured HEK293T and U2OS cells by immunofluorescence-microscopy disclosed a dispersed and punctuated endogenous gephyrin immunoreactivity co-localizing with MTs which was evidently not phosphorylated at Ser270. …”
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    Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270
  8. 2088
    “…We perform whole-exome or genome sequencing of 146 kindreds with sporadic (n = 138) or familial (n = 8) CFM, identifying a highly significant burden of loss of function variants in SF3B2 (P = 3.8 × 10(−10)), a component of the U2 small nuclear ribonucleoprotein complex, in probands. …”
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    Haploinsufficiency of SF3B2 causes craniofacial microsomia
  9. 2089
    “…The mutation status of MET, U2AF1, BCL9, PPP2R1A, IDH2, CBL, BTK, and CHEK2 were positively correlated with poor clinical outcomes. …”
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    MET Mutation Is a Potential Therapeutic Target for Advanced Endometrial Cancer
  10. 2090
    “…Since PAK4 is enriched in cell-cell junctions, we probed the local protein environment around the kinase with a view to understanding its location and substrates. We report that U2OS cells expressing PAK4-BirA-GFP identify a subset of 27 PAK4-proximal proteins that are primarily cell-cell junction components. …”
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    Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions
  11. 2091
    “…The impact on translation and proliferation was confirmed in U2OS and MCF7 cells. Exploiting RIP, eCLIP, and gene expression data, we identified fourteen mitoribosome transcripts we propose as direct DHX30 targets that can be used to explore the prognostic value of this mechanism in cancer. …”
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    DHX30 Coordinates Cytoplasmic Translation and Mitochondrial Function Contributing to Cancer Cell Survival
  12. 2092
    “…We experimentally determined that 115 molecules were nontoxic, and 21 molecules significantly lengthened the period of circadian rhythm in U2OS cells. We then performed a machine learning study to classify these molecules for identifying features that make them toxic and lengthen the circadian period. …”
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    Structure-based design and classifications of small molecules regulating the circadian rhythm period
  13. 2093
    “…Knocking-down ANRIL in SAOS2 resulted in a significant increase in cellular sensitivity to both cisplatin and doxorubicin, while the over-expression of ANRIL in both HOS and U2OS cells led to an increased resistance to both agents. …”
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    Long Non-Coding RNA ANRIL as a Potential Biomarker of Chemosensitivity and Clinical Outcomes in Osteosarcoma
  14. 2094
    “…In this study, we screened 137 crude drug extracts to act as circadian clock modulators in human U2OS cells stably expressing the clock reporter Bmal1-dLuc, and approximately 12% of these modulated the circadian rhythm. …”
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    Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine
  15. 2095
    “…Com o uso de propofol, ocorreu redução média do custo de U$2.998,971 em comparação ao uso do midazolam. A custo-efetividade por hora de permanência na unidade de terapia intensiva evitada e por hora de ventilação mecânica evitada foi dominante, respectivamente, em 94,40% e 80,8% do tempo. …”
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    Uma análise de custo-efetividade de propofol versus midazolam para sedação de pacientes adultos admitidos à unidade de terapia intensiva
  16. 2096
    “…RESULTS: Employing qRT-PCR, Western Blot, and Immunofluorescence techniques, we found that E7 induces an increase in the MPS1 transcript and protein levels in the U2OS cell line, as well as protein stabilization. …”
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    MPS1 is involved in the HPV16-E7-mediated centrosomes amplification
  17. 2097
    “…Several proteins have not been observed in RA so far, such as Tmsb4x, Pura, Nfic, Ruvbl1, Snrpd3, U2af2, Srrm2, Srsf7, Elavl1, Hnrnph1, Wars, Yars, Bzw2, Mcts1, Eif4b, Ctsh, Lamp1, Dpp7, Ptges3, Cdc37 and Septin9, they might be potentials targets for RA. …”
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    Etodolac improves collagen induced rheumatoid arthritis in rats by inhibiting synovial inflammation, fibrosis and hyperplasia
  18. 2098
    “…RESULTS: Four hundred four HL‐DEGs were identified, among which the most up‐regulated 10 genes were AL008707.1, SDR42E1P5, BX005040.1, AL671883.2, MT1XP1, AC016957.1, U2AF1L5, XIST, DAAM2, and ADAMTS2, and the most down‐regulated 10 genes were ALOX15, PRSS33, IL5RA, SMPD3, IGHV1‐2, IGLV3‐9, RHOXF1P1, CACNG6, MYOM2, and RSAD2. …”
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    Web‐based transcriptome analysis determines a sixteen‐gene signature and associated drugs on hearing loss patients: A bioinformatics approach
  19. 2099
    “…Significantly >60 year age group had a higher duration of oxygen requirement (u=2,639.5, p=0.01), while ≤60 year age group had a higher cure rate (X(2)=4.23, p=0.03) and a higher requirement for assisted ventilation (X(2)=4.77, p=0.02). …”
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    Study of Clinical Outcome and Healthcare Modalities of COVID-19 Patients Treated With Remdesivir at a Tertiary Care Teaching Hospital
  20. 2100
    “…Expectedly, many differentially alternative splicing (DAS) events were found under salt stress conditions, and some splicing factors, such as PdRS40, PdRSZ21, PdSR45a, and PdU2Af genes were abnormally spliced under salt, suggesting that AS-related proteins might participated in regulating the salt stress pathway. …”
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    Salt Stress Modulates the Landscape of Transcriptome and Alternative Splicing in Date Palm (Phoenix dactylifera L.)
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