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  1. 2121
    “…Interestingly, we observed the downregulation of seven different U2 spliceosomal RNAs, a type of small nuclear RNAs in severe disease stages. …”
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    Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival
  2. 2122
    “…We also used specific siRNAs and added a cholesterol pathway inhibitor to osteosarcoma cell lines (U2OS and Saos-2) to verify the target. Moreover, PermFIT and ProMS, two support vector machine (SVM) tools, and the least absolute shrinkage and selection operator (LASSO) method, were employed to establish predictive models. …”
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    Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma
  3. 2123
    por Zhu, Jianhui
    Publicado 2021
    “…</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p class="MsoPlainText"><span><span><span style="color:#000000"><span><span><span><span><span><span><span><span><span><span><span><span><a href="https://arxiv.org/abs/2105.06335">https://arxiv.org/abs/2105.06335</a> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> ALICE seminar - 3 august 2021: https://cern.zoom.us/j/69350579682?pwd=ZFFZUG4rVjN6U2VTeXNZVUxDWUFnQT09…”
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    Charm production and hadronisation at the LHC with ALICE
  4. 2124
    “…Genetic analysis revealed a mutational profile defined by DNMT3A/ N/KRAS/ MSH2/ U2AF1 gene mutations that identified refractory/resistant patients. …”
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    Online Artículo Texto
    Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia enrolled in measurable residual disease-oriented trials
  5. 2125
    “…Results: MACROPATATE demonstrated comparable affinity to DOTATATE (dissociation constant, 21 nM) in U2-OS-SSTR2, a SSTR2-positive transfected cell line. (225)Ac-MACROPATATE demonstrated superior serum stability at 37°C over time compared with (225)Ac-DOTATATE. …”
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    (225)Ac-MACROPATATE: A Novel α-Particle Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors
  6. 2126
    “…The ROIs, including the bladder, prostate, rectum, and seminal vesicles, were manually delineated. The U(2)‐Net CNN network architecture was used to train the segmentation model. …”
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    Evaluation of generalization ability for deep learning‐based auto‐segmentation accuracy in limited field of view CBCT of male pelvic region
  7. 2127
    “…Differential analysis of genetic mutations showed FLT3, TP53, MUC16, SRSF2, and KDM5A mutated more frequently (p < 0.050) in secondary acute myeloid leukemia (s‐AML) than in MDS and MPN. TP53, U2AF1, SRSF2, and KDM5A were mutated more frequently (p < 0.050) in s‐AML than in primary AML. …”
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    Gene mutation analysis using next‐generation sequencing and its clinical significance in patients with myeloid neoplasm: A multi‐center study from China
  8. 2128
    por Carreño-Tarragona, Gonzalo, Álvarez-Larrán, Alberto, Harrison, Claire, Martínez-Ávila, José Carlos, Hernández-Boluda, Juan Carlos, Ferrer-Marín, Francisca, Radia, Deepti H., Mora, Elvira, Francis, Sebastian, González-Martínez, Teresa, Goddard, Kathryn, Pérez-Encinas, Manuel, Narayanan, Srinivasan, Raya, José María, Singh, Vikram, Gutiérrez, Xabier, Toth, Peter, Amat-Martínez, Paula, Mcilwaine, Louisa, Alobaidi, Magda, Mayani, Karan, McGregor, Andrew, Stuckey, Ruth, Psaila, Bethan, Segura, Adrián, Alvares, Caroline, Davidson, Kerri, Osorio, Santiago, Cutting, Robert, Sweeney, Caroline P., Rufián, Laura, Moreno, Laura, Cuenca, Isabel, Smith, Jeffery, Morales, María Luz, Gil-Manso, Rodrigo, Koutsavlis, Ioannis, Wang, Lihui, Mead, Adam J., Rozman, María, Martínez-López, Joaquín, Ayala, Rosa, Cross, Nicholas C. P.
    Publicado 2022
    “…We identified 4 high-risk mutated genes, specifically CEBPA (β = 2.26, hazard ratio [HR] = 9.54, P = .003), EZH2 (β = 1.12, HR = 3.062, P = .009), NRAS (β = 1.29, HR = 3.63, P = .048), and U2AF1 (β = 1.75, HR = 5.74, P = .013) using multivariate analysis. …”
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    CNL and aCML should be considered as a single entity based on molecular profiles and outcomes
  9. 2129
    “…We found associations between cognitive outcomes and presence of cerebral atrophy (three studies, N = 453, OR(u) = 2.48, 95% CI = 1.15–4.62), presence of microbleeds (two studies, N = 9151, OR(a) = 1.36, 95% CI = 1.08–1.70), and increasing severity of white matter hyperintensities (three studies, N = 704, OR(a) = 1.26, 95% CI = 1.06–1.49). …”
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    Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysis
  10. 2130
    “…Notably, a direct comparison of CRISPR-dCas labeled genomic loci in live U2OS cells revealed that FLURIL-tagged gRNA yielded loci with signal to background up to 7X greater than loci targeted by guide RNA modified with an array of eight MS2 hairpins. …”
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    Intracellular RNA and DNA tracking by uridine-rich internal loop tagging with fluorogenic bPNA
  11. 2131
    “…Regarding the distance parameters, the MDD, BLD, and height of clinical crowns in males were significantly larger than those in females (MDD: U1, U3, U7, L2, L3, L6, and L7: P < 0.01; BLD: U1: P=0.02; U3–U7 and L1–L7: P < 0.01; height: U2: P=0.03; and U1, U3–U7, and L3–L7: P < 0.01). …”
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    A Comprehensive Analysis of Clinical Crowns in Young of Han Nationality with Normal Occlusion Using Intraoral Scanning
  12. 2132
    “…This revealed comparable mutational profiles in patients younger and older than 76 years, but, interestingly, revealed significantly more prevalent mutated ASXL1, STAG2, and U2AF1 in male compared to female patients. In this cohort of older patients treated with decitabine age and sex, but not comorbidities, physical functioning or cytogenetic risk were associated with overall survival.…”
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    Age and sex associate with outcome in older AML and high risk MDS patients treated with 10-day decitabine
  13. 2133
    “…METHODS: Human lung cancer and osteosarcoma cell lines (SW900, H1975, H460, U2OS) were treated with X-rays and ATR inhibitors (VE822; AZD6738) in the absence and presence of a pan-caspase inhibitor. …”
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    Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases
  14. 2134
    “…After analyzing demographic and genetic features, complementary genetic analyses, including KMT2A-PTD, were suggested for accurate IPSS-M categorization of patients with ASXL1, TET2, STAG2, RUNX1, SF3B1, SRSF2, DNMT3A, U2AF1, and BCOR mutations and those classified as MDS, not otherwise specified with single lineage dysplasia/multi-lineage dysplasia based on the 2022 ICC. …”
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    Validation of the molecular international prognostic scoring system in patients with myelodysplastic syndromes defined by international consensus classification
  15. 2135
    “…Common changes between COS-7 and U2OS cell lines included repression of the retinoic acid signaling pathway and upregulation of sphingolipids. …”
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    Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism
  16. 2136
    “…Cytotoxic activity was tested against a cervical cancer cell line (HeLa), human colon cancer cell line (HCT116), human osteosarcoma cell line (U2OS), and healthy cell line (RPE1). The effect on wound healing was investigated using human keratinocyte cells (HaCaT), while the antibacterial activity of the HYs was tested against growth and adhesion to a polystyrene surface of Staphylococcus aureus and Escherichia coli. …”
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    Significant Benefits of Environmentally Friendly Hydrosols from Tropaeolum majus L. Seeds with Multiple Biological Activities
  17. 2137
    “…Another human strain contains the aminoglycosides-resistance bifunctional AAC/APH (A0A0U2QMQ5) protein, which confers resistance to almost all clinically used aminoglycosides. …”
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    Proteomics and metabolomics analyses of Streptococcus agalactiae isolates from human and animal sources
  18. 2138
    “…The 4′-thio RNA analog exhibits significantly enhanced RNA affinity compared with RNA, and shows potential for incorporation into siRNAs. 2-Thiouridine (s(2)U) and 5-methyl-2-thiouridine (m(5)s(2)U) are natural nucleotide analogs. s(2)U in tRNA confers greater specificity of codon–anticodon interactions by discriminating more strongly between A and G compared with U. 2-Thio modification preorganizes the ribose and 2′-deoxyribose sugars for a C3′-endo conformation, and stabilizes heteroduplexes composed of modified DNA and complementary RNA. …”
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    Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2′-O-[2-(methoxy)ethyl]-2-thiothymidines
  19. 2139
    “…The goals of these studies were to determine the relative ERβ selectivity and pattern of gene expression of these three classes of ERβ-selective compounds compared to estradiol (E(2)), which is a non-selective ER agonist. U2OS cells stably transfected with ERα or ERβ were treated with E(2) or the ERβ-selective compounds for 6 h. …”
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    Drug and Cell Type-Specific Regulation of Genes with Different Classes of Estrogen Receptor β-Selective Agonists
  20. 2140
    “…METHODS AND RESULTS: The use of a tightly adjustable tetracycline (Tet)-dependent HCV protein expression cell system with the founder osteosarcoma cell line U-2 OS allowed switch-off and on of the endogenous production of HCV proteins. …”
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    Hepatitis C virus core protein induces apoptosis-like caspase independent cell death
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