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  1. 2261
    por Moody, Laura, Chen, Hong, Pan, Yuan-Xiang
    Publicado 2020
    “…Not only did we confirm known oncogenes, but we also propose novel tumorigenic genes, such as BSDC1 and U2AF1, that could distinguish between tumor subtypes. …”
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    Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening
  2. 2262
    “…To investigate the similarities and differences between GR and MR signaling in the presence of glucocorticoid hormones, we generated U-2 OS (human osteosarcoma) cell lines stably expressing GR, MR, and both GR and MR (MRGR). …”
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    One Hormone for Two Receptors: Exploring Glucocorticoid Actions Mediated by the Glucocorticoid and Mineralocorticoid Receptors
  3. 2263
    por Yang, Dapeng, Ding, Shiyu, Li, Peipei
    Publicado 2021
    “…The values of the midincisal edge of the upper central incisors (U1), midincisal edge of the upper lateral incisors (U2), upper canine cusp tip (U3), upper first premolar buccal cusp tip (U4), upper second premolar buccal cusp tip (U5), upper first molar mesiobuccal cusp tip (U6MB), and upper first molar distobuccal cusp tip (U6DB) to the TPP were 0.019 mm, 0.279 mm, 0.017 mm, 0.016 mm, 0.016 mm, 0.027 mm, and 0.200 mm, respectively; these values were larger in males than in females (P < 0.05). …”
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    Evaluation of Growth and Development of Adolescents' Dental Arch Asymmetry with Normal Occlusion Using Three-Dimensional Digital Models
  4. 2264
    “…We demonstrate a CLEM workflow generalizable to using other SRM strategies using mitochondria in human osteosarcoma (U2OS) cells as a model system, where immunostained TOM20, a marker for the mitochondrial outer membrane, was used for iPALM. …”
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    Reactive oxygen FIB spin milling enables correlative workflow for 3D super-resolution light microscopy and serial FIB/SEM of cultured cells
  5. 2265
    “…Commonly altered genes (50%) in second head and neck NECs included TP53, RB1, NOTCH2, PTEN, POLG, KMT2C, U2AF1, EPPK1, ELAC2, DAXX, COL22A1, and ABL1. Those genetic lesions might affect p53 signaling, MAPK signaling, PI3K-Akt signaling, sphingolipid signaling, and neurotrophin signaling pathways. …”
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    Pathological and genomic phenotype of second neuroendocrine carcinoma during long-term follow-up after radical radiotherapy for nasopharyngeal carcinoma
  6. 2266
    “…Eight elements (SNRNP70, SNRNP200, U2AF2, RNU4ATAC, RBM3, RBM17, KHDRBS1 and SRSF10) were equally altered in all leucocytes subtypes. …”
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    Splicing machinery is impaired in rheumatoid arthritis, associated with disease activity and modulated by anti-TNF therapy
  7. 2267
    “…Loads in two directions were applied on the upper edge of L1 with a force of 700 N, and vertebral stiffness (VS) was defined as the ratio of 700 N and displacement at the superior reference point: (1) perpendicular to the upper edge of L1 (defined as VS-U); (2) perpendicular to the lower edge of L1(defined as VS-L). …”
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    Biomechanical analysis of vertebral wedge deformity in elderly women with quantitative CT-based finite element analysis
  8. 2268
    “…RESULTS: To test this hypothesis, we stably transfected lowly glycolytic MCF-7, U2-OS, and glycolytic HEK293 cells to express proton-exporting systems: either PMA1 (plasma membrane ATPase 1, a yeast H(+)-ATPase) or CA-IX (carbonic anhydrase 9). …”
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    Proton export upregulates aerobic glycolysis
  9. 2269
    “…In contrast, mutations in U2AF1 were more common in persons < 60 years. Next we tested survival prediction accuracy based on age < or ≥ 60 years. …”
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    IPSS-M has greater survival predictive accuracy compared with IPSS-R in persons ≥ 60 years with myelodysplastic syndromes
  10. 2270
    “…The molecular characterization of 2856 samples (1631 derived from the NGS–AML project; NCT03311815) with standardized NGS of consensus genes (ABL1, ASXL1, BRAF, CALR, CBL, CEBPA, CSF3R, DNMT3A, ETV6, EZH2, FLT3, GATA2, HRAS, IDH1, IDH2, JAK2, KIT, KRAS, MPL, NPM1, NRAS, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, TET2, TP53, U2AF1 and WT1) showed 97% of patients having at least one mutation. …”
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    Molecular Landscape and Validation of New Genomic Classification in 2668 Adult AML Patients: Real Life Data from the PETHEMA Registry
  11. 2271
    “…METHODS: The effect of VRK1 depletion and VRK1 inhibitor, VRK-IN-1, on the acetylation and methylation of histone H3 in K4, K9 and K27 was determined under different conditions, arrested or proliferating cells, in A549 lung adenocarcinoma and U2OS osteosarcoma cells. RESULTS: Chromatin organization is determined by the phosphorylation pattern of histones mediated by different types of enzymes. …”
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    The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase
  12. 2272
    “…StarBase, RNAct and HDOCK showed that several tumor-associated proteins, including U2AF65, hnRNPC, AEBP2, CHIC1 and so on, might interact with MIR99AHG. …”
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    Role of LncRNA MIR99AHG in breast cancer: Bioinformatic analysis and preliminary verification
  13. 2273
    “…The magma-derived U contents are enclosed mainly in the pink granite that is mostly characterized by normal Th/U (2.5–5) and Th/K ratios (3–5*10(–4)). The hydrothermal processes through the alteration zones and mineralized silica veins are reflected by the weak correlation of Th with U (e.g. r = 0.13 and − 0.39), the strong negative correlation of Th/U ratio with U (e.g. r = − 0.82), 2.5˃Th/U˃0.1, Th/K˃5*10(–4), Th/K < 3*10(–4), and the strong positive correlation of U/K with Th/K (e.g. r = 0.91) as well as the occurrence of thorite, columbite, xenotime and hydrothermal zircon (0.5 > Th/U ≤ 0.1). …”
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    Genetic implications of Th/U, Th/K, and U/K ratios for U mineralizations: A case study from El-Missikat and El-Erediya shear zones, Eastern Desert, Egypt
  14. 2274
    “…The most common genetic co-alterations of ROS1+ NSCLC were TP53 (29.1%), SETD2 (7.3%), ARIAD1A (6.3%), and U2AF1 (5.6%). CONCLUSIONS: ROS1+ NSCLC tumors constituted the majority of ROS1+ solid malignancies with four major fusion partners. …”
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    Pan-tumor survey of ROS1 fusions detected by next-generation RNA and whole transcriptome sequencing
  15. 2275
    “…RESULTS: We detected 64 CHIP-associated mutations in 45 individuals (15.7%), most commonly in TET2 (10.8%), DNMT3A (9.2%), and U2AF1 (9.2%). Patients with CHIP tended to be older but did not significantly differ from patients without CHIP in terms of race or native lung disease. …”
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    Prevalence and significance of clonal hematopoiesis of indeterminate potential in lung transplant recipients
  16. 2276
    “…FUNDING: This work was supported by the following grants from the 10.13039/100000002National Institutes of Health: R01DA039934; P20 GM 130414; P30 AI 042853; P30MH058107; T32 DA 043469; U2C DA050098 and the 10.13039/100005192California HIV/AIDS Research Program: OS17-LA-003; H21PC3466.…”
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    Impact of post-incarceration care engagement interventions on HIV transmission among young Black men who have sex with men and their sexual partners: an agent-based network modeling study
  17. 2277
    “…Specific HHV-6A reference strains demonstrated duplication of regions at U1/U2, U87, and U89, as well as deletion in the U12-to-U24 region and the U94/U95 genes. …”
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    Copy Number Heterogeneity, Large Origin Tandem Repeats, and Interspecies Recombination in Human Herpesvirus 6A (HHV-6A) and HHV-6B Reference Strains
  18. 2278
    “…TRIAL REGISTRATION: ClinicalTrials.gov NCT03054051; https://clinicaltrials.gov/ct2/show/NCT03054051 (Archived by WebCite at http://www.webcitation.org/70U2gCNtW)…”
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    A Smartphone Game to Prevent HIV Among Young Africans (Tumaini): Assessing Intervention and Study Acceptability Among Adolescents and Their Parents in a Randomized Controlled Trial
  19. 2279
    “…The sequencing analyses (mRNAs and lncRNAs) of OS were conducted followed by differentially expressed mRNAs and lncRNAs (DEmRNAs and DElncRNAs) identification between U-2OS cells with has-miR-590-5p overexpression and negative control cells. …”
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    Integrated Analysis of Competing Endogenous RNAs Network Reveals Potential Signatures in Osteosarcoma Development
  20. 2280
    “…(Supported by P01 ES022844/RD 83543601, 1U2C ES026553, P30 ES017885)…”
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    Association of Maternal-Neonatal Steroids With Early Pregnancy Endocrine Disrupting Chemicals and Pregnancy Outcomes
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