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21Publicado 1990“…The additional U1- and U2-specific proteins are the 70-kD, A and C proteins and the A' and B" proteins, respectively. …”
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22“…Additional experiments identified factors within CBs that are important for association with the native U2 genes. Inhibition of nuclear export or targeted degradation of U2 snRNPs caused a marked decrease in the levels of U2 snRNA in CBs and strongly disrupted the interaction with U2 genes. …”
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23por Graubert, Timothy A., Shen, Dong, Ding, Li, Okeyo-Owuor, Theresa, Lunn, Cara L., Shao, Jin, Krysiak, Kilannin, Harris, Christopher C., Koboldt, Daniel C., Larson, David E., McLellan, Michael D., Dooling, David J., Abbott, Rachel M., Fulton, Robert S., Schmidt, Heather, Kalicki-Veizer, Joelle, O’Laughlin, Michelle, Grillot, Marcus, Baty, Jack, Heath, Sharon, Frater, John L., Nasim, Talat, Link, Daniel C., Tomasson, Michael H., Westervelt, Peter, DiPersio, John F., Mardis, Elaine R., Ley, Timothy J., Wilson, Richard K., Walter, Matthew J.“…U2AF1 is a U2 auxiliary factor protein that recognizes the AG splice acceptor dinucleotide at the 3′ end of introns and mutations are located in highly conserved zinc fingers in U2AF1(1,2). …”
Publicado 2011
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24por Tefferi, AyalewEnlace del recurso
Publicado 2017
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25por Liu, Chang, Han, Xuesong, Li, Bo, Huang, Shaobin, Zhou, Zhong, Wang, Zhiwei, Wang, Wanming“…PURPOSE: Our study aimed to investigate the relationship between MALAT-1 (metastasis-associated lung adenocarcinoma transcript 1) expression and the chemotherapy drug resistance in osteosarcoma. METHODS: The U-2OS osteosarcoma cell line was selected for the experiment. …”
Publicado 2021
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30por Yu, Yi-Tao, Shu, Mei-Di, Narayanan, Aarthi, Terns, Rebecca M., Terns, Michael P., Steitz, Joan A.“…Here we address the subcellular site of U2 internal modification. Upon injection into the cytoplasm of oocytes, G-capped U2 that is transported to the nucleus becomes modified, whereas A-capped U2 that remains in the cytoplasm is not modified. …”
Publicado 2001
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31“…Their catalytic core comprises three small nuclear RNAs (U2, U5 and U6) involved in substrate positioning and catalysis. …”
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32“…To address this possibility we have looked for evidence of a role for the yeast Tat-SF1 homolog, Cus2, and the U2 snRNA in regulating transcription. Specifically, we have performed a genetic analysis to look for functional interactions between Cus2 or U2 snRNA and the P-TEFb yeast homologs, the Bur1/2 and Ctk1/2/3 complexes. …”
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33“…In the vertebrate lineage of the U1A/U2B″/SNF protein family, the U1A and U2B″ proteins bind to RNA stem–loops in the U1 or U2 snRNPs, respectively. …”
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34por Ilagan, Janine O., Ramakrishnan, Aravind, Hayes, Brian, Murphy, Michele E., Zebari, Ahmad S., Bradley, Philip, Bradley, Robert K.“…Here, we sought to determine how mutations affecting the 3′ splice site recognition factor U2AF1 alter its normal role in RNA splicing. We find that U2AF1 mutations influence the similarity of splicing programs in leukemias, but do not give rise to widespread splicing failure. …”
Publicado 2015
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35por Shirai, Cara Lunn, White, Brian S., Tripathi, Manorama, Tapia, Roberto, Ley, James N., Ndonwi, Matthew, Kim, Sanghyun, Shao, Jin, Carver, Alexa, Saez, Borja, Fulton, Robert S., Fronick, Catrina, O'Laughlin, Michelle, Lagisetti, Chandraiah, Webb, Thomas R., Graubert, Timothy A., Walter, Matthew J.“…In vivo sudemycin treatment of U2AF1(S34F) transgenic mice alters splicing and reverts haematopoietic progenitor cell expansion induced by mutant U2AF1 expression. …”
Publicado 2017
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36por Tefferi, Ayalew, Finke, Christy M., Lasho, Terra L., Hanson, Curtis A., Ketterling, Rhett P., Gangat, Naseema, Pardanani, AnimeshEnlace del recurso
Publicado 2018
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37“…During pre-mRNA splicing, U2 small nuclear ribonucleoprotein auxiliary factor 65 (U2AF65) interacts with U2AF35 and splicing factor 1 (SF1), allowing for the recognition of the 3′-splice site by the ternary complex. …”
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38por Esfahani, Mohammad S., Lee, Luke J., Jeon, Young-Jun, Flynn, Ryan A., Stehr, Henning, Hui, Angela B., Ishisoko, Noriko, Kildebeck, Eric, Newman, Aaron M., Bratman, Scott V., Porteus, Matthew H., Chang, Howard Y., Alizadeh, Ash A., Diehn, Maximilian“…The functional role of U2AF1 mutations in lung adenocarcinomas (LUADs) remains incompletely understood. …”
Publicado 2019
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39por Cretu, Constantin, Gee, Patricia, Liu, Xiang, Agrawal, Anant, Nguyen, Tuong-Vi, Ghosh, Arun K., Cook, Andrew, Jurica, Melissa, Larsen, Nicholas A., Pena, Vladimir“…Splicing modulators alter the splicing patterns in cells by binding to the U2 snRNP (small nuclear ribonucleoprotein)—a complex chaperoning the selection of branch and 3′ splice sites. …”
Publicado 2021
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40“…BACKGROUND: In this work, we explore how U2OS cells are affected by arrays of polymer nanopillars fabricated on flat glass surfaces. …”
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