“…The natural naphthoquinol compound deoxyshikonin exhibits anticancer properties, so we hypothesized that it has an apoptotic effect on osteosarcoma U2OS and HOS cells and studied its mechanisms. After deoxyshikonin treatment, dose‐dependent decreases in cell viability, induction of cell apoptosis and arrest in the sub‐G1 phase of U2OS and HOS cells were observed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Our results showed that EGCG (0.025, 0.05, 0.1, 0.2 g/L) suppresses proliferation of osteosarcoma MG63 and U2OS cells in a concentration-dependent and time-dependent manner and the inhibitory effects of 0.05 g/L EGCG on U2OS cells were roughly equivalent to 20 μM cisplatin (DDP); miR-126 could promote apoptosis and inhibit proliferation in U2OS cells but without significant effects on cell cycle G1 phase arrest; EGCG suppressed proliferation of U2OS cells through induction of cell cycle G1 arrest and apoptotic death; overexpression of miR-126 enhanced the inhibitory effects of EGCG on proliferation in U2OS cells via promotion of apoptosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, Sox2OT-V7 directly targets miR-142/miR-22 to inhibit their expression, and the effect of Sox2OT-V7 silencing on U2OS cell autophagy and U2OS/Dox cell sensitivity to Dox can be reversed by miR-142/miR-22 inhibition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The protein expression levels of TRAF4 in osteosarcoma tissues and three osteosarcoma cell lines, MG-63, HOS, and U2OS, were assessed. Constructed TRAF4 overexpression vectors and established TRAF4 overexpression of the U2OS cell line. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recently, two interview-based studies have suggested that DWMs may also promote the emergence of direct user-to-user (U2U) trading relationships. Here, we carefully investigate and quantify the scale of U2U trading around DWMs by analysing 31 million Bitcoin transactions among users of 40 DWMs between June 2011 and Jan 2021. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, molecular docking studies suggested that U2O is preferentially housed in the domain IIIB of the protein, and its affinity for the albumin is higher than that of the reference ligand HA 14−1 (HDOCK score (top 1–3 poses): −157.11 ± 1.38 (U2O); −129.80 ± 6.92 (HA 14−1); binding energy: −7.6 kcal/mol (U2O); −5.9 kcal/mol (HA 14−1)) and T2O (HDOCK score (top 1–3 poses): −149.93 ± 2.35; binding energy: −7.0 kcal/mol). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We use fluorescence resonance energy transfer (FRET) microscopy to identify interactions of individual SR proteins with the U1 small nuclear ribonucleoprotein (snRNP)–associated 70-kD protein (U1 70K) and with the small subunit of the U2 snRNP auxiliary factor (U2AF35) in live-cell nuclei. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The spliceosome is formed on pre-mRNA substrates from five small nuclear ribonucleoprotein particles (U1, U2, U4/U6 and U5 snRNPs), and numerous non-snRNP factors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MATERIAL/METHODS: Cell viability assay was performed in osteosarcoma cell lines 143B and U2OS. Colony formation analysis was included when cells were treated with different doses of actin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…VEGFA was upregulated in OS tumor tissues and SAOS-2 and U2OS cell lines. The results of CCK-8 assay and transwell assay showed that miR-1 acted as a tumor suppressor by inhibiting cell proliferation, migration, and invasion in U2OS cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Ang1 was induced, and alkaline phosphatase activity was increased by metformin treatment in U2OS and MG63 cells. Wound healing and migration assay showed increased osteoblastic cell mobility by metformin treatment in U2OS and MG63 cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We have found that contrary to a naive U(2) horizontal symmetry expectation, quark mass matrices turn out to be not symmetric. …”
Enlace del recurso
Enlace del recurso

“…RESULTS: Three months after discharge from rehabilitation, the training group (n = 31) showed improvement in health‐related quality of life compared to the control group (n = 29), especially in role limitations due to emotional problems (U = −2.649, p = .008, η (2) = 0.121), energy and fatigue (F[2.55] = 5.72, p = .020, η (2) = 0.062), social functioning (U = −2.137, p = .033, η (2) = 0.076), the average of all SF‐36 factors (U = −2.374, p = .018, η (2) = 0.094), health change from the past year to the present time (U = −2.378, p = .017, η (2) = 0.094), and the mental component summary (U = −2.470, p = .013, η (2) = 0.102). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Increasing levels of miR-137 significantly inhibited U2OS cell viability and invasion (P<0.01). By contrast, knockdown of miR-137 markedly increased U2OS cell viability and invasion. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…GO-Y078 dose-dependently decreased viabilities of human osteosarcoma U2OS, MG-63, 143B, and Saos-2 cells and induced sub-G1 fraction arrest and apoptosis in U2OS and 143B cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A sequencing analysis confirmed the identities of the U1, U2, and U5 snDNA sequences. Additionally, a syntenic condition for U2-U5 snDNA was found in Ancistrus. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we report that two cancer cell lines (U-2 OS and A549) differ significantly in their molecular responses to resveratrol. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Native chromatin immunoprecipitations showed that U2 snRNPs physically interact with nucleosomes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Co-treatment with ERK and JNK inhibitors and nobiletin further reduced U2OS cells migration and invasion. These results indicated that nobiletin inhibits human osteosarcoma U2OS and HOS cells motility, migration and invasion by down-regulating MMP-2 and MMP-9 expressions via ERK and JNK pathways and through the inactivation of downstream NF-κB, CREB, and SP-1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results of MTT and Transwell invasion assays indicated that piperine treatment dose-dependently reduced U2OS and 143B cell viability and invasion. Furthermore, a significant reduction was identified in MMP-2, VEGF, glycogen synthase kinase-3β and β-catenin protein expression levels, as well as the expression levels of their target proteins cyclooxygenase-2, cyclin D1 and c-myc, in U2OS cells after piperine treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso