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Mostrando 481 - 500 Resultados de 2,310 Para Buscar '"U2"', tiempo de consulta: 0.42s Limitar resultados
  1. 481
    “…Apoptosis of U-2OS cells was detected after Chanti-TRIM treatment. …”
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    Target therapy of TRIM-14 inhibits osteosarcoma aggressiveness through the nuclear factor-κB signaling pathway
  2. 482
    “…Overexpression of the miR-29 family sensitized MG-63/MTX and U2OS/MTX cells to MTX and obviously promoted cell apoptosis compared with negative control. …”
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    miR-29 Family Inhibits Resistance to Methotrexate and Promotes Cell Apoptosis by Targeting COL3A1 and MCL1 in Osteosarcoma
  3. 483
    “…In the present study, we investigated the antitumor effect of Polyphyllin VI against human osteosarcoma cells (U2OS) and the underlying molecular mechanisms. METHODS: The U2OS cell lines were used to determine the antiproliferative effect of Polyphyllin VI by CCK8 assay. …”
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    Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
  4. 484
    “…RESULTS: A total of 343 circRNAs were differentially expressed in U2OS-R cells compared with U2OS cells. Among these circRNAs, 253 were upregulated and 90 were downregulated. …”
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    Circular RNA expression pattern in cisplatin-resistant osteosarcoma cells
  5. 485
    “…Here, we report that SSA inhibits pre-mRNA splicing by interfering with the spliceosome subsequent to U2 snRNP addition. We demonstrate that SSA inhibition of spliceosome assembly requires ATP, key pre-mRNA splicing sequences and intact U1 and U2 snRNAs. …”
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    Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
  6. 486
    “…Roots (AQHAR) and performed several in vitro assays using human normal fibroblasts (TIG-3) and osteosarcoma (U2OS). We found that AQHAR caused growth arrest/apoptosis of U2OS cells in a dose-dependent manner. …”
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    Functional Characterisation of Anticancer Activity in the Aqueous Extract of Helicteres angustifolia L. Roots
  7. 487
    por CHEN, Zhi-Ze
    Publicado 2016
    “…In all, berberine can suppress the proliferation and induce the apoptosis of U2OS cell through inhibiting the PI3K/Akt signaling pathway activation. …”
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    Berberine Induced Apoptosis of Human Osteosarcoma Cells by Inhibiting Phosphoinositide 3 Kinase/Protein Kinase B (PI3K/Akt) Signal Pathway Activation
  8. 488
    “…However, p21 plays a minimal role in the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells. In contrast, Bmal1 suppression by siRNA attenuates the anti-proliferative effect of MLN4924 in U2OS osteosarcoma cells, indicating that the MLN4924-mediated cell growth inhibition is mediated by Bmal1. …”
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    Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells
  9. 489
    “…METHODS: IOP was extracted from Inonotus obliquus, human osteosarcoma MG-63 cells and U2OS cells were cultured in vitro, and the effects of IOP on the proliferation, migration, invasion, and apoptosis of MG-63 cells and U2OS cells were determined by CCK-8 assays, cell scratch assays, transwell assays, and flow cytometry, respectively. …”
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    Effects of Inonotus obliquus Polysaccharides on Proliferation, Invasion, Migration, and Apoptosis of Osteosarcoma Cells
  10. 490
    “…Second, BacMam virus-based gene delivery has been successfully applied for the transient expression of non-structural proteins with a subgenomic promoter-EGFP (SP-EGFP) cassette in U-2OS cells to act as an in vitro CHIKV replicon system. …”
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    Recombinant Baculovirus: A Flexible Drug Screening Platform for Chikungunya Virus
  11. 491
    “…In recent years, recurrent hotspot mutations in the spliceosome components U1 snRNA, SF3B1, and U2AF1 have been identified across different tumor types. …”
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    Recurrent Spliceosome Mutations in Cancer: Mechanisms and Consequences of Aberrant Splice Site Selection
  12. 492
    “…CircTADA2A was upregulated while miR-129-5p was downregulated in MG63 and U2OS cells compared. Besides, circTADA2A knockdown inhibited cell proliferation and reduced DDP resistance in both MG63 and U2OS. …”
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    TRPS1 and YAP1 Regulate Cell Proliferation and Drug Resistance of Osteosarcoma via Competitively Binding to the Target of circTADA2A – miR-129-5p
  13. 493
    “…Following intravenous injection of a bolus of [U-(2)H]pyruvate, lactate production was higher in mice bearing orthotopic LGOG (BT88 and SF10417) and GBM (GS2) tumor xenografts relative to tumor-free mice, suggesting that [U-(2)H]pyruvate has the potential to monitor TERT expression in vivo. …”
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    BIMG-08. DEUTERIUM MAGNETIC RESONANCE SPECTROSCOPY USING (2)H-PYRUVATE ALLOWS NON-INVASIVE IN VIVO IMAGING OF TERT EXPRESSION IN BRAIN TUMORS
  14. 494
    “…Here, we leveraged retention using a selective hook (RUSH) system for the identification of human osteosarcoma U2OS cell secretion modulators, through automated, high-throughput screening of small compound libraries. …”
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    Identification of Small Molecules Affecting the Secretion of Therapeutic Antibodies with the Retention Using Selective Hook (RUSH) System
  15. 495
    “…BACKGROUND: Two categories of introns are known, a common U2 type and a rare U12 type. These two types of introns are removed by distinct spliceosomes. …”
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    U12 type introns were lost at multiple occasions during evolution
  16. 496
    por Gu, Bo, Eick, Dirk, Bensaude, Olivier
    Publicado 2013
    “…However, it failed to recruit splicing components such as U2AF65 and U2 snRNA to transcription sites, although the recruitment of U1 snRNA was not affected. …”
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    CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo
  17. 497
    “…The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown to hydroxylate lysine residues in the essential splice factor U2 auxiliary factor 65 kDa subunit (U2AF65) and to act as a modulator of alternative splicing. …”
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    Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine–serine-rich (RS) domains of SR- and SR-like proteins
  18. 498
    por Sung, Kwang Hoon, Song, Hyun Kyu
    Publicado 2014
    “…A single HslV protease exists in each species of prokaryotes, archaea, and eukaryotes, but two HslUs (HslU1 and HslU2) are present in the mitochondria of eukaryotes. …”
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    Insights into the Molecular Evolution of HslU ATPase through Biochemical and Mutational Analyses
  19. 499
    “…NSE levels were deregulated in leukemias and were influenced by the identity of U2AF35 residue 34. We also identify splice-switching oligonucleotides (SSOs) that exploit competition of adjacent pseudoexons to modulate NSE levels. …”
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    Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting
  20. 500
    “…It indicated that U2-S2-I might be the major active fraction of the hydrolysate. …”
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    Preparation of Antioxidant Peptides from Salmon Byproducts with Bacterial Extracellular Proteases
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