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Mostrando 501 - 520 Resultados de 2,310 Para Buscar '"U2"', tiempo de consulta: 0.42s Limitar resultados
  1. 501
    “…Confocal microscopy and live cell imaging of actin in U2OS cells indicate that PAWS1 is also involved in cytoskeletal dynamics and organization. …”
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    PAWS1 controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP
  2. 502
    “…Finally, we show that immature but not fully assembled snRNPs are able to induce CB formation and that microinjection of an excess of U2 snRNP-specific proteins, which promotes U2 snRNP maturation, chases U2 snRNA from CBs. …”
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    The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation
  3. 503
    “…To address this issue, we previously developed a novel production cell line, called U2OS-ICP4/27, by lentiviral transduction of human osteosarcoma U2OS cells with two essential HSV IE genes, ICP4 and ICP27. …”
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    Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes
  4. 504
    “…A proximity ligation assay was utilised to assess protein to protein interactions in the osteosarcoma U2OS and prostate carcinoma PC3 cell lines. U2OS and PC3 cells exhibited a significantly increased intra-nuclear interaction between MT1-MMP and HIF-2α in response to hypoxia. …”
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    Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2α in osteosarcoma and prostate carcinoma cells
  5. 505
    “…Additionally, FEZF1-AS1 knockdown inhibited cell proliferation, migration, and invasion in U2OS and MG63 cells, while upregulation had the opposite effects in vitro. …”
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    Long Noncoding RNA FEZF1-AS1 Promotes Osteosarcoma Progression by Regulating the miR-4443/NUPR1 Axis
  6. 506
    “…We highlighted the development of four chromosomal FISH markers from repetitive genes such as U2 small nuclear RNA linked to 5S rRNA sequence (U2 snRNA-5S), 18S rRNA, histone H3, and uncharacterized gene FP-9X. …”
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    Karyotypic analysis and isolation of four DNA markers of the scleractinian coral Favitespentagona (Esper, 1795) (Scleractinia, Anthozoa, Cnidaria)
  7. 507
    por Saha, Kaushik, Ghosh, Gourisankar
    Publicado 2022
    “…By probing the early spliceosomal complexes in vitro and RNA-protein interactions in vivo, we show that the SR proteins bind the pre-mRNAs cooperatively generating a substrate that recruits U1 snRNP and U2AF65 in a splice signal-independent manner. Excess U1 snRNP selectively displaces some of the SR protein molecules from the pre-mRNA generating the substrate for splice signal-specific, sequential recognition by U1 snRNP, U2AF65 and U2AF35. …”
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    Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly
  8. 508
    “…CD44V3 splicing was regulated by U2AF1 and downregulation of U2AF1 enhanced CD44V3 expression, which promoted pancreatic cancer progression. …”
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    CD44V3, an Alternatively Spliced Form of CD44, Promotes Pancreatic Cancer Progression
  9. 509
    “…Three reverse osmosis (RO) units were operated with a control (U1), CO(2) (U2), and a commercial antiscalant, MDC-220 (U3). …”
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    CO(2) as an Alternative to Traditional Antiscalants in Pressure-Driven Membrane Processes: An Experimental Study of Lab-Scale Operation and Cleaning Strategies
  10. 510
    “…The 5′ phosphate of U2 moves by 2.6 Å and the U2 base is placed near the six-membered ring of A2 in AAUAAA, where it makes two hydrogen bonds with zinc finger 2 (ZF2) of CPSF30, which undergoes conformational changes as well. …”
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    Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF
  11. 511
    “…The patient recovered quickly after splenectomy, which confirms that his myelodysplastic syndrome (MDS)-associated U2AF1 mutation did not affect the clinical picture. …”
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    Acquired spherocytosis in the setting of myelodysplasia
  12. 512
    “…[Image: see text] Previous characterizations of diactinide endohedral metallofullerenes (EMFs) Th(2)@C(80) and U(2)@C(80) have shown that although the two Th(3+) ions form a strong covalent bond within the carbon cage, the interaction between the U(3+) ions is weaker and described as an “unwilling” bond. …”
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    Are U–U Bonds Inside Fullerenes Really Unwilling Bonds?
  13. 513
    “…Applying our approach to a partial complex of U2 snRNP allowed us to identify the contact site between the U2 snRNP-specific protein p14/SF3b14a and the branch-site interacting region (BSiR) of U2 snRNA.…”
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    Improved identification of enriched peptide–RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry
  14. 514
    “…These results demonstrate a novel role for acetylation by SAGA in co-transcriptional recruitment of the U2 snRNP and recognition of the intron branchpoint.…”
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    Acetylation by the Transcriptional Coactivator Gcn5 Plays a Novel Role in Co-Transcriptional Spliceosome Assembly
  15. 515
    “…The PtK cell line has been extensively used as a model for cytoskeletal dynamics during cell migration. The U2OS cell line serves as a model for a complex, single migrating cell. …”
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    An Intact Centrosome Is Required for the Maintenance of Polarization during Directional Cell Migration
  16. 516
    “…The element binds specifically to heterogeneous nuclear ribonucleo protein (hnRNP) K in a phosphatase-sensitive way, which directly competes with the U2 auxiliary factor U2AF65, an essential component of early spliceosomes. …”
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    Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation
  17. 517
    “…Nisins A, Z, F and Q are produced by Lactococcus lactis, while Nisins U and U2 are produced by Streptococcus sp. In this study we bioengineered the nisA gene of a Nisin A producer to generate genes encoding Nisins Z, F, Q, U and U2. …”
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    Bioengineering of a Nisin A‐producing Lactococcus lactis to create isogenic strains producing the natural variants Nisin F, Q and Z
  18. 518
    “…A subset of these introns has been shown to be spliced at a slower rate compared to the major U2-type introns. This suggests a rate-limiting regulatory function for the minor spliceosome in the processing of transcripts containing U12-type introns. …”
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    Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome
  19. 519
    “…RLN2 was overexpressed in the U2-OS cells by treatment with recombinant relaxin. …”
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    RLN2 Is a Positive Regulator of AKT-2-Induced Gene Expression Required for Osteosarcoma Cells Invasion and Chemoresistance
  20. 520
    “…Additionally, a LARS-rescue experiment was performed to explore the potential target in U2OS using Western blot and flow cytometry. Luciferase reporter assay was designed to analyze the effect of of hsLARS inhibitor on p21 activation. …”
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    A human leucyl-tRNA synthetase as an anticancer target
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