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681por Serrat, Xènia, Kukhtar, Dmytro, Cornes, Eric, Esteve-Codina, Anna, Benlloch, Helena, Cecere, Germano, Cerón, Julián“…In a screen, we identified RNAi of U2 snRNP components that cause synthetic lethality with sftb-1/SF3B1 mutations. …”
Publicado 2019
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682“…Mutations in LUC7L2, PRPF8, SF3B1, SRSF2, U2AF1, and ZRSR2 genes occur at various frequencies ranging between 40% and 85% in different subtypes of myelodysplastic syndrome (MDS) and 5% and 10% of acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs). …”
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683“…To assist in the evolutionary and taxonomic understanding of this group, classical cytogenetic techniques were used to find possible molecular markers for the genus through rDNA5S, rDNA18S, and U2snDNA probes and analyze their chromosome distribution in the group of T. miliaris. …”
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684“…HAGLROS knockdown inhibited certain functions of U2OS and SW1353 cells in vitro. Moreover, HAGLROS depletion inhibited tumor growth and metastasis in vivo. …”
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685por do Nascimento, Cristiano Neves, Troy, Waldo Pinheiro, Alves, José Carlos Pansonato, Carvalho, Margarida Lima, Oliveira, Claudio, Foresti, Fausto“…Single and multiple histone H1 sites were observed in all the species, and histone H1 was shown to be co-located with the 18S rRNA gene in a single chromosome pair. The U2 snDNA gene was distributed at multiple sites in all the Moenkhausia species. …”
Publicado 2020
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686“…Ectopically expressing PADI4 positively regulates the colony formation capacity of both U2OS and Saos-2 cells. Furthermore, we explored the related mechanism and showed that PADI4 could stimulate Wnt/β-catenin and MEK/ERK signaling in both U2OS and Saos-2 cells. …”
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687por Ferreira de Oliveira, José Miguel P., Almeida, Joana Filipa D., Martins, Maria, Proença, Carina, Oliveira, Helena, Fernandes, Eduarda, Santos, Conceição“…In this study, 3′,4′-dihydroxyflavonol (DiOHF) was investigated to assess the effects in OS cellular models in combination with doxorubicin (Dox). MG-63 and U2OS human OS cells were exposed to DiOHF and Dox and tested for cell viability and growth. …”
Publicado 2021
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688por Zhu, Yun-Rong, Zhang, Xiang-Yang, Wu, Qiu-Ping, Yu, Cheng-Jian, Liu, Yuan-Yuan, Zhang, Yun-Qing“…In vivo, PF-06409577 oral administration at well-tolerated doses potently inhibited growth of U2OS cells and primary human OS cells in severe combined immunodeficient mice. …”
Publicado 2021
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689por Sobierajska, Paulina, Pozniak, Blazej, Tikhomirov, Marta, Miller, Julia, Mrowczynska, Lucyna, Piecuch, Agata, Rewak-Soroczynska, Justyna, Dorotkiewicz-Jach, Agata, Drulis-Kawa, Zuzanna, Wiglusz, Rafal J.“…The cytotoxicity assessment was carried out on the human osteosarcoma cell line (U2OS), murine macrophages (J774.E), as well as human red blood cells (RBCs). …”
Publicado 2021
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690“…Overall, we have shown that the arginine methylation of hnRNPK suppresses the apoptosis of U2OS cells via interfering with DDX3–hnRNPK interaction. …”
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691por Douet-Guilbert, Nathalie, Soubise, Benoît, Bernard, Delphine G., Troadec, Marie-Bérengère“…Then, we present and discuss other splicing genes that are showing a prognostic interest (SRSF2, U2AF1, ZRSR2, U2AF2, and PRPF8). Finally, we discuss the haploinsufficiency of splicing genes, especially from chromosomes 5 and 7, the important amplifier process of splicing defects, and the cumulative and synergistic effect of splicing genes defects in the MDS pathogenesis. …”
Publicado 2022
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692por Kage, Frieda, Vicente-Manzanares, Miguel, McEwan, Brennan C., Kettenbach, Arminja N., Higgs, Henry N.“…Interestingly, while NMIIC is the least abundant NMII in U2OS cells (>200-fold less than NMIIA and >10-fold less than NMIIB), its knockout is equally deleterious to CIA. …”
Publicado 2022
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693“…We established a stable firefly luciferase reporter gene knock-in U2-OS cell line by CRISPR/Cas9 to screen circadian-rhythm-disrupting pollutants. …”
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694por Coffin, J P“…Particular emphasis is put on the case of the H/sup 0/ (a 2u2d2s quark bag or alternately two coupled Lambda /sup 0/). (9 refs).…”
Publicado 2001
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696por Bakas, Ioannis“…Applications to the chirally invariant $U(2)$ Gross--Neveu model are also discussed.…”
Publicado 1994
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697“…Investigating the open string spectrum on D3-branes, we will show that one can interpolate in this way between N=4 supersymmetric U(N) respectively U(2N) Yang-Mills theories and non-supersymmetric U(N)*U(N) gauge theories with adjoint massless scalar fields plus bifundamental massless fermions in a smooth way. …”
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698“…We found that identifying a U2 candidate helped identify U6 and U4 based on interactions between them. …”
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699“…In the present study we expressed PML isoforms with a mutated NLS in U2OS cells to identify potential cytoplasmic compartments targeted by this protein. …”
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700por Tsuchiya, Megumi, Ogawa, Hidesato, Suzuki, Taiga, Sugiyama, Noriyuki, Haraguchi, Tokuko, Hiraoka, Yasushi“…Interaction between endogenous Exp4 and Sox9 proteins was confirmed in the human osteosarcoma U2OS cells by immunoprecipitation experiments using anti-Sox9 antibody. siRNA depletion of Exp4 enhanced transcription of Sox9 target genes in U2OS cells, but did not affect nuclear localization of Sox9. …”
Publicado 2011
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